Efficacy of Platelet-rich Plasma for Treating Androgenic Alopecia of Varying Grades

Platelet‐rich plasma injections in the treatment of male androgenetic alopecia: A randomized placebo‐controlled crossover study

“…Therefore, we cannot exclude the possibility that the ineffectiveness of PRP treatment at the primary endpoints in our study was related to the disease stage and/or the relatively small number of patients in Group 1 who received PRP first. In addition, in a recent study, regarding specific effectiveness of PRP treatment for different grades of male AGA, Qu et al found that lower level of alopecia (grades II and III) had better response to PRP and had a better tendency of increment of hair growth than that of high‐grade patients with prolonged treatment . In studies of PRP treatment of AGA patients, different evaluation methods have been used for the assessment of hair growth.…”

Platelet‐rich plasma for androgenetic alopecia: Efficacy differences between men and women

“…Platelet-rich plasma significantly increased hair density in men (MD: 25.83, confidence interval (CI): 15.48-36.17, 12 studies, N = 250, P < .00001, I 2 = 65%; Figure 2). [11][12][13][14][15][16][17]24,31,32,41 Treatment frequency and assessment time of studies ranged from 1 to 8 PRP injections and 3 to 12 months after the first treatment, respectively (Table 1). There was insufficient data to permit analysis of PRP treatment number or frequency on hair density.…”

“…Five studies used the single spin method to prepare PRP, 12,13,16,31,32 five used the double spin method, 11,14,15,17,24 and two studies did not report the method. 16,41 Six studies reported the use of a PRP activator, [11][12][13][15][16][17] three studies reported using non-activated PRP, 16,31,32 and three did not report whether an activator was used or not 14,24,41 (Table 1). studies, N = 88, P = .07, I 2 = 54%) 12,13,16,31,32 (Figure 3).…”

“…reporting a beneficial effect, [18][19][20][21][22][23][24][25] while others report that PRP is not as effective or not effective at all for women. [26][27][28] Furthermore, some studies have also reported that PRP is not effective for AGA in men.…”

Platelet-derived bio-products: Classification update, applications, concerns and new perspectives

“…The main uses of PRP in ophthalmology are dry eye, graft-versus-host disease, persistent epithelial defects, corneal ulcers or perforations, burns and post-LASIK syndrome (27,(48)(49)(50). The regenerative potential of platelet-rich products has also been tested in tympanic perforation (51,52), skin lesions (53) -such as skin ulcers of multifactorial etiology: diabetic foot (54-56), pressure ulcers (57,58), venous ulcers (59) and even leprosy ulcers (60)-, vitiligo (61) and androgenetic alopecia (62). In the area of gynecology there are reports of the use of PRP to aid wound healing and recovery in caesarean delivery, vulvovaginal atrophy, benign cervical ectopy and it has also been applied in reproductive medicine and erectile dysfunction (63)(64)(65)(66)(67)(68)(69).…”