“Efficacy of photodynamic therapy on the treatment of herpes labialis: A systematic review”

Lotufo, Mônica Andrade; Horliana, Anna Carolina Ratto Tempestini; Santana, Thalita; Queiroz, Aline; Gomes, Andréa Oliver; Motta, Lara Jansiski; Mesquita‐Ferrari, Raquel Agnelli; Fernandes, Kristianne Porta Santos; Bussadori, Sandra Kalil

doi:10.1016/j.pdpdt.2019.08.018

Cited by 47 publications

(30 citation statements)

References 18 publications

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“…Oral herpes is caused by human herpes simplex virus 1 (HHV-1) and causes pain on the lips, tongue, and the roof of the mouth. [76] Other human herpes infections include the HHV-2 virus that causes genital herpes, the HHV-3 virus that causes chickenpox and herpes zoster, the HHV-4 (Epstein-Barr) and HSV-5 (cytomegalovirus) viruses that cause infectious www.advancedsciencenews.com www.advancedscience.com Schematic of the mechanisms of antiviral drugs. Reproduced with permission.…”

Section: Antiviral Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Antiviral Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…In oral candidiasis, a topical application may be applied by the selection of the affected areas only, and light can be applied to those regions only, making these infections treatable by PDT, without antifungal agents (presented in Figure 3). PDT has also been described to be used for the management of lesions in the oral cavity caused by the herpes simplex virus (or HSV), which are also commonly seen in clinical practices [87]. PDT, using methylene blue as a photosensitizer has been considered as an option in the treatment of herpes labialis; results have shown a decrease in the recurrence of vesicles and an increase in the comfort level of patients.…”

Section: Pdt In Oral and Maxillofacial Surgery Oral Medicine And Oramentioning

confidence: 99%

Utility of Photodynamic Therapy in Dentistry: Current Concepts

et al. 2020

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The significant growth in scientific and technological advancements within the field of dentistry has resulted in a wide range of novel treatment modalities for dentists to use. Photodynamic therapy (PDT) is an emerging, non-invasive treatment method, involving photosensitizers, light of a specific wavelength and the generation of singlet oxygen and reactive oxygen species (ROS) to eliminate unwanted eukaryotic cells (e.g., malignancies in the oral cavity) or pathogenic microorganisms. The aim of this review article is to summarize the history, general concepts, advantages and disadvantages of PDT and to provide examples for current indications of PDT in various subspecialties of dentistry (oral and maxillofacial surgery, oral medicine, endodontics, preventive dentistry, periodontology and implantology), in addition to presenting some images from our own experiences about the clinical success with PDT.

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“…The recommendation for new studies using PDT in this context is necessary. For instance, a recent systematic review was unable to confirm the effectiveness of PDT in the treatment of herpetic lesions (cold sores) 4 , which is a much less complex disease entity. We suggest that, according to our initial experience acquired in the management of the reported cases, and with the lack of robust literature, photobiomodulation therapy (PBMT) or other adjuvant treatments should only be employed in COVID-19 patients with symptomatic oral ulcerative lesions that do not respond to conventional therapy.…”

mentioning

confidence: 99%

“…Authors: Thaís Bianca Brandão DDS, PhD 1,2 ; Luiz Alcino Gueiros DDS, PhD 3 ; Thayanara Silva Melo DDS, MSc 3 ; Ana Carolina Prado-Ribeiro DDS, PhD 2,4 ; Gladys Villas Boas do Prado MD, PhD 5 ; Alan Roger Santos-Silva DDS, PhD 4 The suggestion about using PDT to help the healing of lesions in COVID-19 infected patients has merit. However, it has not yet been investigated.…”

mentioning

confidence: 99%

Reply: Insights and challenges in the management of oral lesions in patients with COVID-19

Brandão

Gueiros

Melo

et al. 2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“Efficacy of photodynamic therapy on the treatment of herpes labialis: A systematic review”

Cited by 47 publications

References 18 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Utility of Photodynamic Therapy in Dentistry: Current Concepts

Reply: Insights and challenges in the management of oral lesions in patients with COVID-19

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