Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Al‐Maweri, Sadeq Ali; Ashraf, Sajna; Kalakonda, Butchibabu; Halboub, Esam; Petro, W; Alaizari, Nader Ahmed

doi:10.1111/jop.12684

Cited by 30 publications

(38 citation statements)

References 29 publications

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“…A randomized clinical trial indicated a better efficacy of PDT therapy compared to corticosteroids [58]. Generally, PDT treatment was able to reduce pain and burning sensation and to decrease the size of the lesions in symptomatic OLP patients [53].…”

Section: Therapeutic Management Of Oral Lichen Planusmentioning

confidence: 99%

“…Psoralen and ultraviolet A (PUVA) therapy has been successfully used in severe and refractory cases of erosive OLP [52]. However, a systematic review on the efficacy of photodynamic therapy (PDT) in the management of symptomatic OLP showed inconsistent results [53]. For example, two studies reported similar efficacy of PDT and corticosteroids [54,55], while two other studies showed that PDT was inferior to corticosteroids [56,57].…”

Section: Therapeutic Management Of Oral Lichen Planusmentioning

confidence: 99%

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Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP

Meşter

Lucaciu

Ciobanu

et al. 2018

Bosn J of Basic Med Sci

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Oral lichen planus (OLP) is a chronic inflammatory disease characterized by the occurrence of multiple, symmetrical lesions in the oral cavity. Hepatitis C virus (HCV) infection has been suggested as an etiological factor in OLP. The purpose of this review was to summarize the current literature regarding the treatment of OLP in patients with HCV infection. An electronic search of the PubMed database was conducted until January 2018, using the following keywords: OLP, HCV, corticosteroids, retinoids, immunomodulatory agents, surgical interventions, photochemotherapy, laser therapy, interferon, ribavirin, and direct-acting antivirals. We selected the articles focusing on the clinical features and treatment management of OLP in patients with/without HCV infection. Topical corticosteroids are considered the first-line treatment in OLP. Calcineurin inhibitors or retinoids can be beneficial for recalcitrant OLP lesions. Systemic therapy should be used in the case of extensive and refractory lesions that involve extraoral sites. Surgical intervention is recommended for isolated lesions. In patients with HCV, monotherapy with interferon (IFN)-α may either improve, aggravate or trigger OLP lesions, while combined IFN-α and ribavirin therapy does not significantly influence the progression of lesions. Direct-acting antiviral (DAA) therapy appears to be a promising approach in patients with HCV-related OLP, as it can improve symptoms of both liver disease and OLP, with fewer side effects. Nevertheless, for clinical utility of DAAs in OLP patients, further studies with larger sample sizes, adequate treatment duration, and long term follow-up are required.

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Section: Therapeutic Management Of Oral Lichen Planusmentioning

confidence: 99%

Section: Therapeutic Management Of Oral Lichen Planusmentioning

confidence: 99%

Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP

Meşter

Lucaciu

Ciobanu

et al. 2018

Bosn J of Basic Med Sci

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“…They concluded that PRP could be used in the erosive form, which proved to be successful once a week when implemented 3 . In Photodynamic therapy, a photosensitizing compound (methylene blue), triggered by laser light at a certain wavelength, is used in photodynamic therapy to kill the targeted cell using powerful oxidizers that trigger cell destruction, membrane lysis and protein inactivation, and has been successfully used to relieve OLP symptoms in adult patients 5,23 .A systematic review of the effectiveness of ( PDT) in symptomatic OLP treatment, however, revealed contradictory findings. Two trials, for instance, documented comparable efficacy of PDT and corticosteroids 24,25 .…”

mentioning

confidence: 99%

Oral lichen planus and its recent management: A review

Iqbal¹,

Yesmin

Maaisha

et al. 2020

Update Dent. Coll. j

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Background: Oral Lichen Planus (OLP) is one of the most common dermatological disease which is present in the oral cavity. It is a chronic autoimmune, mucocutaneous disease that affects oral mucosa as well as the skin, genital mucosa and other sites of the body.Method: In this review study, various databases such as Google Scholar, PubMed Central, Hinari and Cochrane library were searched for articles with keywords lichen planus, oral lichen planus, premalignant lesions, management of Lichen planus. Articles were searched from January 2015 to 5th November 2020.Result: From the 34 articles obtained after reviewing the abstracts, most relevant 32articles were evaluated in this study.Conclusion: The etiology, pathophysiology, clinical presentation, histopathological features, diagnosis and various management for oral lichen planus is discussed. This article also compares the existing and the most recent treatment modalities that are available throughout the world that are discussed in the literatures. However, more intensive studies must be carried out to find the best treatments which are cost-effective in the long run. Update Dent. Coll. j: 2020; 10 (2): 29-34

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“…This can be explained by the fact that different photosensitizers (ALA, methylene blue, toluidine blue, etc.) and various light sources (diode laser, light emitting diode) are employed (44). Grandi et al reviewed the data on the efficacy of PDT in OLP therapy.…”

Section: The Role Of Photodynamic Therapy In Oral Lichen Planusmentioning

confidence: 99%

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Tocut¹,

Mitran²,

Mitran³

et al. 2019

JMMS

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Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results. Keywords  oral lichen planus, photosensitizer, therapy Highlights  The therapeutic approach in the OLP remains a challenge; although many therapies are available, none of them can still be considered the ideal therapeutic approach.  PDT seems to be a promising therapy, but with heterogeneous results due to lack of standardization (the available studies using different sources of light, wavelengths and photosensitizers).

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Efficacy of photodynamic therapy in the treatment of symptomatic oral lichen planus: A systematic review

Cited by 30 publications

References 29 publications

Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP

Clinical features and management of oral lichen planus (OLP) with emphasis on the management of hepatitis C virus (HCV)-related OLP

Oral lichen planus and its recent management: A review

Photodynamic therapy as a new therapeutic approach of oral lichen planus

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