Efficacy of photoactivated Myrciaria cauliflora extract against Staphylococcus aureus infection – A pilot study

Santos, Denisar Palmito dos; Lopes, Diego Patrick Soares; Calado, Stefano Pedro de Melo; Gonçalves, Caroline Vieira; Muniz, Igor Pereira Ribeiro; Ribeiro, Israel Souza; Galantini, Maria Poliana Leite; Silva, Robson Amaro Augusto da

doi:10.1016/j.jphotobiol.2018.12.011

Cited by 18 publications

(5 citation statements)

References 46 publications

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“…(Grapefruit/Pomelo) -(Rutaceae) [56] (Moraceae) [56] e) Ficus carica L. (Common fig) -(Moraceae) [56] a Myrciaria cauliflora (Mart.) O.Berg (Jaboticaba) -(Myrtaceae) [112] Americas Several minor related coumarins have been reported in the roots of Ruta pinnata [154] . These include Gravelliferone methyl ether, xanthyletin, furopinnarin, pinnarin, benahorin, limettin, luvangetin, bergapten and sabandinin.…”

Section: Discussionmentioning

confidence: 99%

“…& Broome) Sacc. -(Parasitic fungi Clavicipitaceae) [105] China λmax~502-510 nm in polar solvents like ethanol or DMSO [105,106,129] Phenalenone deriva- Americas, including Brazil Fruits [112] λmax~310-320 nm depending on solvent [112] Polyphenol Type I -(Amaranthaceae) [52] b) Ammi majus L. (Bishop's weed) -(Apiaceae) [52] a Curcuma longa L. (Curcuma) -(Zingiberaceae) [41,[145][146][147]157] Tropical belt, including Brazil Rhizomes Phototoxicity demonstrated in several cancer cell lines and bacteria.…”

Section: Citrus Medicamentioning

confidence: 99%

“…DC. -(Asteraceae) [41] Genus Berkheya -(Asteraceae) [41] Genus Dyssodia -(Asteraceae) [41] Genus Echinops -(Asteraceae) [41] Genus Bidens -(Asteraceae) [41,160] a) Russia, China b) Worldwide, including Brazil c) Russia d) South America, including Brazil c) Root d) Aerial part ROS production after UV irradiation [157] Phototoxic in skin and uterine cancer cell lines [106] λmax~210-225 nm depending on solvent [47,106,140] Xanthone [112] b) Red fruits, red-purple dark vegetables, black rice [96] a) Americas, including Brazil Fruits Reports in superior plants [96,112] [ 96,112] Furanosesquiterpene Type II American and European coastlines, including Brazil Oils Hepato-induced photosensisitization [38,54] Lectin Type II Lectin Arachis hypogaea : PNA Protein Arachis hypogaea L. (Peanut) -(Fabaceae) [109] Worldwide, including Brazil…”

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confidence: 99%

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A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

Petit,

Izambart,

Guillou

et al. 2023

Chemistry & Biodiversity

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This study provides a comprehensive overview of the current knowledge regarding phototoxic terrestrial plants and their phototoxic and photosensitizing metabolites. Within the 435,000 land plant species, only around 250 vascular plants have been documented as phototoxic or implicated in phototoxic occurrences in humans and animals. This work compiles a comprehensive catalog of these phototoxic plant species, organized alphabetically based on their taxonomic family. The dataset encompasses meticulous details including taxonomy, geographical distribution, vernacular names, and information on the nature and structure of their phototoxic and photosensitizing molecule(s). Subsequently, this study undertook an in‐depth investigation into phototoxic molecules, resulting in the compilation of a comprehensive and up‐to‐date list of phytochemicals exhibiting phototoxic or photosensitizing activity synthesized by terrestrial plants. For each identified molecule, an extensive review was conducted, encompassing discussions on its phototoxic activity, chemical family, occurrence in plant families or species, distribution within different plant tissues and organs, as well as the biogeographical locations of the producer species worldwide. The analysis also includes a thorough discussion on the potential use of these molecules for the development of new photosensitizers that could be used in topical or injectable formulations for antimicrobial and anticancer phototherapy as well as manufacturing of photoactive devices.

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Section: Discussionmentioning

confidence: 99%

Section: Citrus Medicamentioning

confidence: 99%

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confidence: 99%

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A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

Petit,

Izambart,

Guillou

et al. 2023

Chemistry & Biodiversity

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“…However, the hypericin-induced PDT had no antibacterial effect on the growth of the E. coli strain. dos Santos et al [55] conveys the use of Myrciaria cauliflora (Mart.) O. Berg extract as a photosensitizer which, when exposed to light, was active against S. aureus.…”

Section: Discussionmentioning

confidence: 99%

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

2021

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Antibiotic therapy and photodynamic therapy (PDT) are commonly used to treat bacterial infections. Unfortunately, these methods are often ineffective. Therefore, agents that could effectively support antibiotic therapy and PDT in the inactivation of pathogens are being sought. Phytotherapy seems to be a good solution. The aim of the current research was to examine whether Polypodium vulgare extract (PvE) would improve the effectiveness of PDT and ciprofloxacin (CIP), an antibiotic that is commonly used to treat urinary tract infections in humans. UHPLC-MS analysis was performed to establish the PvE content. Chlorin e6 has been used as a photosensitizer in the PDT method. Biofilm production was established using the spectrophotometric method. The live cell count in planktonic and biofilm consortia was determined with the microdilution method and DAPI staining. The decrease of the bacterial survival, biofilm mass synthesis, and morphological changes of the bacteria under the combined treatments: PDT+PvE and CIP+PvE was noted. The results clearly indicate that the PvE can be used as a good agent for improving the efficacy of both PDT and the CIP activity to inactivate uropathogenic Escherichia coli strains. The obtained results are of particular value in the era of widespread and still-increasing drug resistance among bacterial pathogens.

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“…Santos et al 60 evaluated curcumin-mediated PDI effects in MRSA using 100 μg/mL curcumin and a 54 J/cm² fluence, obtaining complete inactivation of that bacterial stain.…”

Section: Photodynamic Inactivationmentioning

confidence: 99%

Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation

Melo

Tovar

Dovigo

et al. 2023

Photodiagnosis and Photodynamic Therapy

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Efficacy of photoactivated Myrciaria cauliflora extract against Staphylococcus aureus infection – A pilot study

Cited by 18 publications

References 46 publications

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

A Review of Phototoxic Plants, Their Phototoxic Metabolites, and Possible Developments as Photosensitizers

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation

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