Efficacy of Phage Therapy in Controlling Rabbit Colibacillosis and Changes in Cecal Microbiota

Zhao, Jian; Liu, Yan; Xiao, Chen; He, Shaojie; Yao, Huochun; Bao, Guolian

doi:10.3389/fmicb.2017.00957

Cited by 21 publications

(14 citation statements)

References 30 publications

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“…(3) Gastrointestinal delivery (Tanji et al, 2005;Capparelli et al, 2006;Raya et al, 2006;Sheng et al, 2006;Niu et al, 2008;Rozema et al, 2009;Bach et al, 2009;Jamalludeen et al, 2009;Mai et al, 2010;Stanford et al, 2010;Maura et al, 2012;Jaiswal et al, 2013;Abdulamir et al, 2014;Jaiswal et al, 2014;Jun et al, 2014;Mai et al, 2015;Nale et al, 2015;Sarker et al, 2016;Nikkhahi et al, 2017;Yen et al, 2017;Zhao et al, 2017;Vahedi et al, 2018;Bhandare et al, 2019;Dallal et al, 2019;Dissanayake et al, 2019;Xue et al, 2020) 26 ( 36) (Sarker et al, 2017;Corbellino et al, 2019)…”

Section: (17)unclassified

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2021

Current Issues in Molecular Biology

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Pharmacology can be differentiated into two key aspects, pharmacodynamics and pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while pharmacokinetics describes the body's impact on a drug. Another way of understanding these terms is that pharmacodynamics is a description of both the positive and negative consequences of drugs attaining certain concentrations in the body while pharmacokinetics is concerned with our ability to reach and then sustain those concentrations. Unlike the drugs for which these concepts were developed, including antibiotics, the bacteriophages (or 'phages') that we consider here are not chemotherapeutics but instead are the viruses of bacteria. Here we review the pharmacology of these viruses, particularly as they can be employed to combat bacterial infections (phage therapy). Overall, an improved pharmacological understanding of phage therapy should allow for more informed development of phages as antibacterial 'drugs', allow for more rational post hoc debugging of phage therapy experiments, and encourage improved design of phage therapy protocols. Contrasting with antibiotics, however, phages as viruses impact individual bacterial cells as single virions rather than as swarms of molecules, and while they are killing bacteria, caister.com/cimb 81 Curr. Issues Mol. Biol. Vol. 40bacteriophages also can amplify phage numbers, in situ. Explorations of phage therapy pharmacology consequently can often be informed as well by basic principles of the ecological interactions between phages and bacteria as by study of the pharmacology of drugs. Bacteriophages in phage therapy thus can display somewhat unique as well as more traditional pharmacological aspects.

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Section: (17)unclassified

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2021

Current Issues in Molecular Biology

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“…The administration of phages can be through different delivery routes, including parenteral (intramuscular, intravenous, intraperitoneal), oral, and local phage delivery systems [152][153][154][155].…”

Section: Routes Of Administrationmentioning

confidence: 99%

Bacteriophages for Chronic Wound Treatment: From Traditional to Novel Delivery Systems

Pinto

Cerqueira

Bañobre-Lópes

et al. 2020

Viruses

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The treatment and management of chronic wounds presents a massive financial burden for global health care systems, with significant and disturbing consequences for the patients affected. These wounds remain challenging to treat, reduce the patients' life quality, and are responsible for a high percentage of limb amputations and many premature deaths. The presence of bacterial biofilms hampers chronic wound therapy due to the high tolerance of biofilm cells to many firstand second-line antibiotics. Due to the appearance of antibiotic-resistant and multidrug-resistant pathogens in these types of wounds, the research for alternative and complementary therapeutic approaches has increased. Bacteriophage (phage) therapy, discovered in the early 1900s, has been revived in the last few decades due to its antibacterial efficacy against antibiotic-resistant clinical isolates. Its use in the treatment of non-healing wounds has shown promising outcomes. In this review, we focus on the societal problems of chronic wounds, describe both the history and ongoing clinical trials of chronic wound-related treatments, and also outline experiments carried out for efficacy evaluation with different phage-host systems using in vitro, ex vivo, and in vivo animal models. We also describe the modern and most recent delivery systems developed for the incorporation of phages for species-targeted antibacterial control while protecting them upon exposure to harsh conditions, increasing the shelf life and facilitating storage of phage-based products. In this review, we also highlight the advances in phage therapy regulation.

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“…Gastrointestinal delivery (Tanji et al, 2005;Capparelli et al, 2006;Raya et al, 2006;Sheng et al, 2006;Niu et al, 2008;Rozema et al, 2009;Bach et al, 2009;Jamalludeen et al, 2009;Mai et al, 2010;Stanford et al, 2010;Maura et al, 2012;Jaiswal et al, 2013;Abdulamir et al, 2014;Jaiswal et al, 2014;Jun et al, 2014;Mai et al, 2015;Nale et al, 2015;Sarker et al, 2016;Nikkhahi et al, 2017;Yen et al, 2017;Zhao et al, 2017;Vahedi et al, 2018;Bhandare et al, 2019;Dallal et al, 2019;Dissanayake et al, 2019;Xue et al, 2020) 26 (36) (Sarker et al, 2017;Corbellino et al, 2019)…”

Section: (7)unclassified

Phage Therapy: The Pharmacology of Antibacterial Viruses

Danis-Wlodarczyk¹,

Dąbrowska²,

Abedon³

2020

Bacterial Viruses: Exploitation for Biocontrol and Therapeutics

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Pharmacology can be differentiated into two key aspects, pharmacodynamics and pharmacokinetics. Pharmacodynamics describes a drug's impact on the body while pharmacokinetics describes the body's impact on a drug. Another way of understanding these terms is that pharmacodynamics is a description of both the positive and negative consequences of drugs attaining certain concentrations in the body while pharmacokinetics is concerned with our ability to reach and then sustain those concentrations. Unlike the drugs for which these concepts were developed, including antibiotics, the bacteriophages (or 'phages') that we consider here are not chemotherapeutics but instead are the viruses of bacteria. Here we review the pharmacology of these viruses, particularly as they can be employed to combat bacterial infections (phage therapy). Overall, an improved pharmacological understanding of phage therapy should allow for more informed development of phages as antibacterial 'drugs', allow for more rational post hoc debugging of phage therapy experiments, and encourage improved design of phage therapy protocols. Contrasting with antibiotics, however, phages as viruses impact individual bacterial cells as single virions rather than as swarms of molecules, and while they are killing bacteria, 49 bacteriophages also can amplify phage numbers, in situ. Explorations of phage therapy pharmacology consequently can often be informed as well by basic principles of the ecological interactions between phages and bacteria as by study of the pharmacology of drugs. Bacteriophages in phage therapy thus can display somewhat unique as well as more traditional pharmacological aspects. Abd El-Aziz, A.M., Elgaml, A., and Ali, Y.M. (2019). Bacteriophage therapy increases complement-mediated lysis of bacteria and enhances bacterial clearance after acute lung infection with multidrug-resistant Pseudomonas aeruginosa.

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Efficacy of Phage Therapy in Controlling Rabbit Colibacillosis and Changes in Cecal Microbiota

Cited by 21 publications

References 30 publications

Phage Therapy: The Pharmacology of Antibacterial Viruses

Phage Therapy: The Pharmacology of Antibacterial Viruses

Bacteriophages for Chronic Wound Treatment: From Traditional to Novel Delivery Systems

Phage Therapy: The Pharmacology of Antibacterial Viruses

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