Efficacy of passive immunization in broiler chicks via an inactivated <i>Escherichia coli</i> autogenous vaccine administered to broiler breeder hens

Keïta, Alassane; Devendec, Laëtitia Le; Amelot, Michel; Puterflam, Julie; Lucas, Camille; Bougeard, Stéphanie; Delannoy, Sabine; Schouler, Catherine; Fach, Patrick; Lucas, Pierrick; Souillard, Rozenn; Kempf, Isabelle

doi:10.1080/03079457.2022.2084362

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…This study confirms previous results obtained by pullet immunization with a multivalent APEC autogenous vaccine where mortality rate was reduced in the vaccinated groups, compared to contemporaneous control groups, in challenge models [12,13]. The present study also adds to the knowledge of the impact of autogenous vaccine usage in breeders by evidencing a significant positive effect on the health and performance of progeny, which had been observed previously under experimental conditions for one of the two tested challenge strains [14], but not in a field trial.…”

Section: Discussionsupporting

confidence: 92%

“…Also, the transfer of anti-APEC maternal antibodies to their progeny after vaccination has been demonstrated under experimental conditions, with the use of a candidate enterobactin conjugate vaccine [9]. Furthermore, broiler chickens were proven protected by passive immunity further to the immunization of their female ascendants with an autogenous inactivated vaccine under experimental conditions [14]. It is then reasonable to conclude that, in the present field trial, APEC-specific antibodies induced by the multivalent inactivated autogenous vaccine induced a significant protection in the progeny of the laying hens via passive transfer of maternal antibodies, and that this protection was significant.…”

Section: Discussionmentioning

confidence: 99%

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Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco

Oubouyahia,

Essalah-Bennani,

Fassi Fihri

et al. 2023

Preprint

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Excessive use of antibiotics to control colibacillosis on poultry farms in Morocco contributes to the development of multiresistant avian pathogenic E. coli. Autogenous vaccines are an alternative to antibiotic usage; the main goal of this study was to assess the efficacy of this approach to control recurrent outbreaks of colibacillosis in a large broiler production flow. A tetravalent autogenous vaccine (serotypes O78, O88, O91, and O185) was produced from E. coli strains isolated from clinical lesions in breeding hens and used on two farms (65,000 breeding hens in total). On each farm, contemporaneous groups were included: groups vaccinated twice (12 and 18 weeks of age) and unvaccinated control groups. The performances of these flocks, as well as the performances of broilers hatched from these breeders (12 farms, over 600,000 broilers in total), were recorded. A significant reduction in lesion scores, mortality rate and a significant increase in the number of saleable day-old chicks were observed among vaccinated hens. In broilers, body weight at slaughter, lesion scores, food conversion ratio, mortality and condemnation rates were significantly improved. This is the first field observation of a lasting effect of breeder hens immunization with an autogenous vaccine against E. coli on their offspring.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco

Oubouyahia,

Essalah-Bennani,

Fassi Fihri

et al. 2023

Preprint

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“…However, there is limited evidence regarding their effectiveness. In a study conducted by Keita et al (2022), passive immunization using a bivalent formalin-killed autogenous vaccine was found to be effective in reducing mortality when chicks were challenged with one of two E. coli strains [30]. This indicates strain-specific protection provided by the vaccine.…”

Section: Killed Vaccinesmentioning

confidence: 98%

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

Paudel,

Apostolakos,

Vougat Ngom

et al. 2024

PLoS ONE

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Colibacillosis, a disease caused by Escherichia coli in broiler chickens has serious implications on food safety, security, and economic sustainability. Antibiotics are required for treating the disease, while vaccination and biosecurity are used for its prevention. This systematic review and meta-analysis, conducted under the COST Action CA18217—European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT), aimed to assess the efficacy of E. coli vaccination in broiler production and provide evidence-based recommendations. A comprehensive search of bibliographic databases, including, PubMed, CAB Abstracts, Web of Science and Agricola, yielded 2,722 articles. Following a defined protocol, 39 studies were selected for data extraction. Most of the studies were experimental infection trials, with only three field studies identified, underscoring the need for more field-based research. The selected studies reported various types of vaccines, including killed (n = 5), subunit (n = 8), outer membrane vesicles/protein-based (n = 4), live/live-attenuated (n = 16), and CpG oligodeoxynucleotides (ODN) (n = 6) vaccines. The risk of bias assessment revealed that a significant proportion of studies reporting mortality (92.3%) or feed conversion ratio (94.8%) as outcomes, had “unclear” regarding bias. The meta-analysis, focused on live-attenuated and CpG ODN vaccines, demonstrated a significant trend favoring both vaccination types in reducing mortality. However, the review also highlighted the challenges in reproducing colibacillosis in experimental setups, due to considerable variation in challenge models involving different routes of infection, predisposing factors, and challenge doses. This highlights the need for standardizing the challenge model to facilitate comparisons between studies and ensure consistent evaluation of vaccine candidates. While progress has been made in the development of E. coli vaccines for broilers, further research is needed to address concerns such as limited heterologous protection, practicability for application, evaluation of efficacy in field conditions and adoption of novel approaches.

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“…The vaccine strain has a decisive impact on the efficacy of vaccination, but the choice of the adjuvant and the inactivation method should be well thought out (30,86,88). Possible factors further influencing the efficacy of breeder vaccination with an autogenous vaccine against E. coli include inoculation dose and route, hen age, and the number of strains used in the vaccine (89). In laying hens, the use of an autogenous vaccine in affected flocks may help to reduce morbidity and mortality and lessen the impact on egg production.…”

Section: Escherichia Coli (Colibacillosis)mentioning

confidence: 99%

Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

Sulejmanovic,

Schnug,

Philipp

2023

Avian Diseases

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Efficacy of passive immunization in broiler chicks via an inactivated Escherichia coli autogenous vaccine administered to broiler breeder hens

Cited by 4 publications

References 38 publications

Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco

Positive Assessment of an Autogenous Vaccine Against Pathogenic Escherichia coli in Broiler Breeders and their Progeny in Morocco

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

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