Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: A comparison with methotrexate

Yamasaki, Simone Cristina; Mendes, Mariana Trivilin; Alponti, Rafaela Fadoni; Silveira, Paulo Flávio

doi:10.1016/j.toxicon.2015.02.016

Cited by 7 publications

(9 citation statements)

References 55 publications

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“…BV injection (0.25 mg/kg) was an effective modulator of rheumatoid arthritis, inhibiting protease activities and removing reactive oxygen species (ROS) [ 94 ]. In addition, in combination use with methotrexate, BV may have increased bioavailability and antiarthritic effects [ 95 ]. Reduced hepatotoxicity was mostly due to the decreased expression of TNF-α and NF-kB (p65) in the synovial membrane of the hind paw [ 91 ].…”

Section: Clinical Applications and Mechanism Of Bv Injectionmentioning

confidence: 99%

Clinical Applications of Bee Venom Acupoint Injection

Lin

Hsieh

2020

Toxins

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Bee venom is a complex natural mixture with various pharmaceutical properties. Among these properties, its peptides and enzymes have potential medical therapy for pain relief and inflammation. In clinical settings, this therapy has been used widely to treat diseases by injecting into acupoints. In this article, we have conducted various research from PubMed, Cochrane Library, and Clinical Key from inception of July 2020. The results revealed that bee venom therapy has been reported effective in anti-inflammatory, antiapoptosis, and analgesic effects. Moreover, bee venom acupuncture has been commonly used for clinical disorders such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple sclerosis, skin disease and cancer.

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Section: Clinical Applications and Mechanism Of Bv Injectionmentioning

confidence: 99%

Clinical Applications of Bee Venom Acupoint Injection

Lin

Hsieh

2020

Toxins

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“…The pain reduction effects and mechanisms of collagen-, adjuvant-, and formalininduced inflammatory pain in a mouse model [22][23][24][25][26] were confirmed through animal studies. However, all included studies confirmed the treatment effect of inflammatory pain following a single BVA treatment.…”

Section: Discussionmentioning

confidence: 95%

“…Two experimental studies [ 22 , 23 ] have investigated arthritis pain in a mouse model. BV (1 mg/200 g) showed anti-nociceptive activity in Freund’s complete adjuvant (FCA) and collagen type-II-induced rats with arthritis pain [ 22 ].…”

Section: Therapeutic Effects Of Bva In Painmentioning

confidence: 99%

Bee Venom Acupuncture Effects on Pain and Its Mechanisms: An Updated Review

Sung

Lee

2021

Toxins

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Bee venom (BV) is a complex natural toxin that contains various pharmaceutical compounds. Bee venom acupuncture (BVA), involving a BV injection into a certain acupuncture point, has been utilized to relieve a range of pain conditions. Regardless of whether pain is caused by disease or injury, if not effectively treated, pain can exert a detrimental effect on all aspects of life. In the past decade, many researchers have investigated the anti-nociceptive effects of BVA through clinical use and experimental evaluation. This report reviews the existing knowledge on the analgesic effects of BVA, focusing on musculoskeletal pain, inflammatory pain and neuropathic pain, and its analgesic mechanisms. Although further clinical trials are needed to clinical application of experimental results, this review will contribute to the standardization and generalization of BVA.

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“…It is also a frequently used treatment, and approximately 37.4% of the patients treated in TKM clinics have experienced pharmacopuncture treatment [ 4 , 5 ]. Pharmacopuncture is currently being used to treat skin diseases [ 6 , 7 ], mental illness [ 8 ], arthritis [ 9 ], musculoskeletal diseases [ 2 , 10 ], circulatory diseases [ 11 ], and gastric disease [ 12 ]. It is also being used as a part of cancer care to address chemotherapy-induced nausea and vomiting [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Quality Control of Pharmacopuncture: A Comparative Study of Good Manufacturing Practice and External Herbal Dispensary Standards

Han

Park

et al. 2021

J Pharmacopuncture

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Objectives We aimed to compare the external herbal dispensary (EHD) evaluation criteria for pharmacopuncture and the Korea Good Manufacturing Practice (KGMP) sterile medicine standards to contribute to the establishment of quality control criteria for pharmacopuncture. Methods We obtained the KGMP standards from the Ministry of Food and Drug Safety and the pharmacopuncture certification criteria from the Ministry of Health and Welfare of South Korea. The EHD evaluation items were classified into three categories facilities, quality control, and validation. The evaluation items were compared with the KGMP sterile medicine criteria to determine their conformance with each other, followed by a discussion among the committee of six experts and their consensus to suggest the items to complement the EHD evaluation criteria. Results Among the KGMP sterile medicine criteria, 44 were related to the management of the facilities, and 32 pharmacopuncture evaluation items corresponded to these KGMP items (66.7%). Fifty-eight KGMP criteria were related to quality management, and 42 pharmacopuncture evaluation items corresponded to these KGMP items (72.4%). Twenty-five KGMP sterile medicine criteria were related to validation, and 11 pharmacopuncture evaluation items corresponded to these KGMP items (44.0%). Sixteen items under the pharmacopuncture EHD criteria corresponded to the KGMP sterile medicine criteria based on the consent of the experts. Among these, 4 were related to facility management, 6 were related to quality control, and 6 were related to validation. Conclusion For the safety and quality control of pharmacopuncture, there is a need to select the criteria for the mandatory items among the proposed pharmacopuncture-EHD criteria laws and systems to ensure that the pharmacopuncture materials are produced under the pharmacopuncture-EHD in compliance with the relevant requirements. More studies are needed to secure the safety level of pharmacopuncture materials corresponding to that of conventional medicine.

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Efficacy of parenteral administration of bee venom in experimental arthritis in the rat: A comparison with methotrexate

Cited by 7 publications

References 55 publications

Clinical Applications of Bee Venom Acupoint Injection

Clinical Applications of Bee Venom Acupoint Injection

Bee Venom Acupuncture Effects on Pain and Its Mechanisms: An Updated Review

Quality Control of Pharmacopuncture: A Comparative Study of Good Manufacturing Practice and External Herbal Dispensary Standards

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