Efficacy of oxolinic acid and other bactericides in suppression ofErwinia amylovora in pear orchards in Israel

Shtienberg, D.; Zilberstaine, Miriam; Oppenheim, D.; Herzog, Ze’ev; Manulis, Shulamit; Shwartz, H.; Kritzman, G.

doi:10.1007/bf02983958

Cited by 40 publications

(18 citation statements)

References 20 publications

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“…However, streptomycin use in plant agriculture in the USA has been replaced by oxytetracycline, due to streptomycin resistance development among E. amylovora in the apple orchards. Oxolinic acid had been reported to be used in Israel against fire blight and against rice blight in Japan (Shtienberg et al, 2001). Gentamicin is used in Mexico and Central America to control Fire Blight and various diseases of vegetable crops (Stockwell and Duffy, 2012).…”

Section: The Veterinary Medicine and Agriculture Sectormentioning

confidence: 99%

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

Cantas¹,

Shah²,

Cavaco³

et al. 2013

Front. Microbiol.

298

211

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The discovery and introduction of antimicrobial agents to clinical medicine was one of the greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial infections. However, the gradual emergence of populations of antimicrobial-resistant pathogenic bacteria resulting from use, misuse, and abuse of antimicrobials has today become a major global health concern. Antimicrobial resistance (AMR) genes have been suggested to originate from environmental bacteria, as clinically relevant resistance genes have been detected on the chromosome of environmental bacteria. As only a few new antimicrobials have been developed in the last decade, the further evolution of resistance poses a serious threat to public health. Urgent measures are required not only to minimize the use of antimicrobials for prophylactic and therapeutic purposes but also to look for alternative strategies for the control of bacterial infections. This review examines the global picture of antimicrobial resistance, factors that favor its spread, strategies, and limitations for its control and the need for continuous training of all stake-holders i.e., medical, veterinary, public health, and other relevant professionals as well as human consumers, in the appropriate use of antimicrobial drugs.

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Section: The Veterinary Medicine and Agriculture Sectormentioning

confidence: 99%

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

Cantas¹,

Shah²,

Cavaco³

et al. 2013

Front. Microbiol.

298

211

View full text Add to dashboard Cite

show abstract

“…In the 1990s, an attempt to register gentamicin for plant agriculture in the USA was contested, owing to its clinical importance, and the application was withdrawn without prejudice (McManus et al, 2002). Oxolinic acid, a synthetic quinolone antibiotic, is used only in Israel to manage fire blight of pear and related plants, especially in areas where E. amylovora is resistant to streptomycin (Shtienberg et al, 2001). Oxolinic acid also is registered in Japan for management of bacterial panicle blight of rice, caused by Burkholderia glumae (Maeda et al, 2004;Nandakumar et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of antibiotic performances on Trichoderma harzianum and some crop infecting fungi

Akonda¹,

Himel²,

Ali³

et al. 2016

Plant Sci. Today

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An in vitro experiment was carried out to evaluate the effectiveness of antibiotics at different concentrations on growth and development of Trichoderma harzianum, Phytophthora infestans, Colletotrichum gloeosporioides, Corticium theae and Fusarium oxysporum found in tea plantation. Three samples viz. sample-1 (Validamycin 60% w/w) @ 45, 60 and 75 ppm, sample-2 (Hexaconazole 2.5% w/w+Validamycin 8.5% w/w) @ 55, 82.5 and 110 ppm and sample-3 (Streptomycin 9% w/w+Tetracyclin hydrochloride 1% w/w) @ 50, 75 and 100 ppm were tested. The result showed that Antibiotics have inhibitory effects on T. harzianum. Unsatisfactory performances in terms of per cent growth inhibition (<80) were recorded on crop infecting fungi. C. theae treated with sample-1 @ 75 ppm and C. gloeosporioides with sample-2 @ 110 ppm had shown maximum 25.50 and 54.19 per cent growth inhibition, respectively. The highest 70.53 per cent growth inhibition of C. theae was observed in sample-3 treated @ 100 ppm. Considering the findings it can be recommended not to use above antibiotics with their respective concentrations in plant agriculture for controlling diseases caused by the said fungi.

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“…Since 1997 use of streptomycin has not been recommended and has been replaced by oxolinic acid (OA), which has been exclusively used for fire blight management in commercial orchards. The efficacy of OA against E. amylovora was evaluated in 13 orchard experiments in 1997–2000; a concentration of 300 µ g mL −1 was highly effective and significantly reduced disease severity in all experiments (Shtienberg et al ., 2001). Pear growers apply OA sprays during bloom according to the local decision‐support systems (Shtienberg et al ., 2003).…”

Section: Introductionmentioning

confidence: 99%

Erwinia amylovora populations resistant to oxolinic acid in Israel: prevalence, persistence and fitness

et al. 2005

Self Cite

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Oxolinic acid (OA) has been the only bactericide used against fire blight in pear and quince orchards in Israel since 1998. OA-resistant Erwinia amylovora strains ( Ea-OA R ) were detected in several orchards in two restricted areas in the northern Galilee region during 1999-2001. In the following years, resistant strains could not be detected in some of these locations. Documenting the fate of Ea-OA R strains in commercial orchards at eight sites in northern Israel during 2000/03 revealed that the resistant population appeared irrespective of the number of sprays applied and the severity of the disease. The persistence of the Ea-OA R populations varied from site to site, ranging from 4 to 20 months; these differences could be attributed to the fire blight management activities of growers. Comparative studies on the fitness of Ea-OA R and E. amylovora strains sensitive to OA ( Ea-OA S ) were conducted in vitro and in planta using two strains of each group. In four of the six comparisons, disease incidence on detached blossoms inoculated with Ea-OA S was significantly higher than that on blossoms inoculated with Ea-OA R . In two experiments conducted on 8-year-old pear trees grown under netting, the colonization of Ea-OA S in blossoms, annual shoots and perennial spurs was significantly higher than that of the Ea-OA R . In two experiments conducted on 2-year-old trees grown under netting in an experimental station, the incidence of shoots exhibiting fire blight symptoms and the rate of symptom progress within the branches were significantly higher in trees inoculated with Ea-OA S than in those inoculated with Ea-OA R . The results of this study suggest that OA-resistant E. amylovora strains have lower fitness than wild-type strains. These findings may have implications for fire blight management.

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Efficacy of oxolinic acid and other bactericides in suppression ofErwinia amylovora in pear orchards in Israel

Cited by 40 publications

References 20 publications

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

In vitro evaluation of antibiotic performances on Trichoderma harzianum and some crop infecting fungi

Erwinia amylovora populations resistant to oxolinic acid in Israel: prevalence, persistence and fitness

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