Efficacy of oseltamivir in the treatment of patients infected with Covid-19

Zendehdel, Abolfazl; Bidkhori, Mohammad; Ansari, Mohsen; Jamalimoghaddamsiyahkali, Saeidreza; Asoodeh, Azadeh

doi:10.1016/j.amsu.2022.103679

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Patients that received oseltamivir showed a shorter hospitalization time and faster recovery compared to patients that received Azithromycin and Hydroxychloroquine. Furthermore, patients that received oseltamivir showed a lower mortality ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of drug regimen with and without oseltamivir in hospitalized patients with COVID-19: A retrospective study

Shokri¹,

Rezapoor²,

Najafi³

et al. 2023

Vacunas

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Section: Discussionmentioning

confidence: 99%

Efficacy of drug regimen with and without oseltamivir in hospitalized patients with COVID-19: A retrospective study

Shokri¹,

Rezapoor²,

Najafi³

et al. 2023

Vacunas

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“…Herbs, natural drugs or related analogs are important alternative therapies in the prevention, treatment, and recovery from the infection. The mortality rate was found to be lower in patients treated with oseltamivir, an anti-influenza drug synthesized using two natural products, quinic acid and shikimic acid, than in the control group (1.7% vs. 6.7%, p = 0.06), and the administration of oseltamivir was associated with a shorter length of hospital stay and earlier recovery/discharge from hospital [ 90 ]. A number of natural compounds have proven to have anti-human coronavirus activities [ 91 , 92 , 93 ], and certain combinations of herbs are effective to prevent the infection and relieve the associated symptoms, but further research on natural products to identify more potent new leads is urgently needed.…”

Section: Selected Bioactive Natural Products and Analogsmentioning

confidence: 99%

Lead/Drug Discovery from Natural Resources

Eichler

Klausner

et al. 2022

Molecules

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Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.

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“…In one study, ivermectin inhibited the importin (IMP) α/β1-mediated nuclear import of viral proteins, which disrupted the immune escape mechanism of the virus [65] . Oseltamivir specifically inhibits neuraminidase, which can inhibit the separation of the mature virus from host cells, thereby improving the disease situation; it is more effective in combination with other antiviral drugs [66] . However, some drugs used in the antiviral process can cause kidney damage.…”

Section: Sars-cov-2 and Kidney Diseasementioning

confidence: 99%