Efficacy of organo-selenium-incorporated urinary catheter tubing for in vitro growth inhibition of E. coli, K. pneumoniae, P. aeruginosa, and H. influenzae

Jacobo, Unique; Vopni, Rachel; Tran, Phat L.; Patel, Shruti; Jain, Suyash; Riese, Cornelia S. de; Reid, Ted W.; Riese, Werner de

doi:10.1007/s11255-022-03422-y

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…[47,48]. These organoselenum compounds have been used as coatings for polyester bandages [49], scleral buckles [50], contact lenses [51], catheter tubing [52], and even cotton socks [53].…”

Section: Introductionmentioning

confidence: 99%

“…[47,48]. These organoselenum compounds have been used as coatings for polyester bandages [49], scleral buckles [50], contact lenses [51], catheter tubing [52], and even cotton socks [53]. To the best of our knowledge, none of these studies have investigated the application of reactive OS compounds, i.e., OS compounds possessing a reactive functional group for covalent attachment to cellulose, the main component of cotton fabric.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Coatings for Medical Textiles via Reactive Organo-Selenium Compounds

Hoque,

Tran,

Jacobo

et al. 2023

Molecules

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Bleached and cationized cotton fabrics were chemically modified with reactive organoselenium compounds through the nucleophilic aromatic substitution (SNAr) reaction, which allowed for organo-selenium attachment onto the surface of cotton fabrics via covalent bonds and, in the case of the cationized cotton fabric, additional ionic interactions. The resulting textiles exhibited potent bactericidal activity against S. aureus (99.99% reduction), although only moderate activity was observed against E. coli. Fabrics treated with reactive organo-selenium compounds also exhibited fungicidal activities against C. albicans, and much higher antifungal activity was observed when organo-selenium compounds were applied to the cationized cotton in comparison to the bleached cotton. The treatment was found to be durable against rigorous washing conditions (non-ionic detergent/100 °C). This paper is the first report on a novel approach integrating the reaction of cotton fabrics with an organo-selenium antimicrobial agent. This approach is attractive because it provides a method for imparting antimicrobial properties to cotton fabrics which does not disrupt the traditional production processes of a textile mill.

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“…[47,48]. These organoselenum compounds have been used as coatings for polyester bandages [49], scleral buckles [50], contact lenses [51], catheter tubing [52], and even cotton socks [53].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Coatings for Medical Textiles via Reactive Organo-Selenium Compounds

Hoque,

Tran,

Jacobo

et al. 2023

Molecules

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Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material

Tran,

Presson,

Kashem

et al. 2024

Antibiotics

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To further investigate the inhibition of Pseudomonas aeruginosa’s in vitro growth and biofilm formation by an organo-selenium-incorporated polyurethane (PU) catheter material. P. aeruginosa, Staphylococcus aureus, and Candida albicans were incubated in vitro with organo-selenium and control polyurethane catheter materials in the presence of glutathione. Growth was evaluated by a colony-forming-unit (CFU) count and visualized with confocal laser scanning microscopy. Two different PU catheter materials were used. Using tin-catalyzed PU catheter material, complete inhibition of S. aureus was seen at 1% selenium (Se), whereas no inhibition was seen for P. aeruginosa at up to 3.0% Se. Whereas, using a thermoplastic PU catheter material, 1.5% Se and 2% Se organo-selenium caused several logs of growth inhibition of P. aeruginosa, and 2.5% selenium, incorporation showed complete inhibition (8 logs). Samples with lower than 1.5% selenium did not show adequate growth inhibition for P. aeruginosa. Similar in vitro growth inhibition was achieved against a multidrug-resistant C. albicans strain. It was concluded that optimal inhibition of P. aeruginosa in vitro growth and biofilm formation occurs with 2.5% selenium incorporated as organo-selenium in a thermoplastic PU catheter material. These results suggest that reduced incidence of CAUTIs (catheter associated urinary tract infections) with P. aeruginosa and other bacteria and fungi can be achieved by using organo-selenium-incorporated catheters.

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Efficacy of organo-selenium-incorporated urinary catheter tubing for in vitro growth inhibition of E. coli, K. pneumoniae, P. aeruginosa, and H. influenzae

Cited by 2 publications

References 26 publications

Antimicrobial Coatings for Medical Textiles via Reactive Organo-Selenium Compounds

Antimicrobial Coatings for Medical Textiles via Reactive Organo-Selenium Compounds

Complete Growth Inhibition of Pseudomonas aeruginosa by Organo-Selenium-Incorporated Urinary Catheter Material

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