Efficacy of Orally Administered Extract of Red Vine Leaf AS 195 (folia vitis viniferae) in Chronic Venous Insufficiency (Stages l-ll)

Kiesewetter, H.; Koscielny, Jürgen; Kalus, Ulrich; Vix, J.-M.; Peil, Hubertus; Petrini, Orlando; Toor, B. S. J. Van; Mey, Christian de

doi:10.1055/s-0031-1300174

Cited by 46 publications

(59 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Red vine leaf extract (RVLE) is herbal medicine involving numerous flavonoids as the major active ingredients thereof [16]. It contains not less than 4% of total polyphenols and 0.2% of anthocyanins [15].…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts

Lin

Chen

Huang

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol which are effective for skin hyperpigmentation. The five components contents are 1.03, 0.2, 18.55, 6.45, and 0.48 mg/g for gallic acid, chlorogenic acid, epicatechin, rutin, and resveratrol. The kinetic study showed the tyrosinase inhibitory of RVLE via a competitive reaction mechanism. RVLE solution has an IC50 (the half inhibitory concentration) value of 3.84 mg/mL for tyrosinase inhibition, that is, an effective tyrosinase inhibitory activity, and can be used as a whitening agent for cosmetic formulations in the future.

show abstract

Section: Introductionmentioning

confidence: 99%

Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts

Lin

Chen

Huang

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Red grape leaves are used as a medicine for venous insufficiency in the Mediterranean area (Kiesewetter et al 2000;Schaefer et al 2003). RGLE contains abundant multiple polyphenolic compounds, such as stilbenes, anthocyanins, flavanols, flavonols, flavons, and ellagitannins (Bombardelli and Morazzoni 1995;Monagas et al 2006), but its biologic and nutritional effects are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Red grape leaf extract improves endurance capacity by facilitating fatty acid utilization in skeletal muscle in mice

et al. 2011

View full text Add to dashboard Cite

Improving endurance capacity leads to increased athletic performance and active lifestyles. The aim of this study was to investigate the effect of the intake of red grape leaf extract (RGLE), used as a traditional herbal medicine in the Mediterranean area, on endurance capacity in mice. Male BALB/c mice were divided into three experimental groups with similar swimming times and body weights; control group, 0.2% (w/w) and 0.5% RGLE group. Swimming times were measured for evaluation of endurance capacity once a week during the 10-week experimental period. Blood and tissues were collected from anesthetized mice immediately after 30 min of swimming exercise, and analyzed blood component and fatty acid oxidation enzyme activity, and gene expression in soleus muscle and mesenteric adipose tissue. Endurance capacity was improved by RGLE in a dose-related manner, and was significantly longer in the 0.5% RGLE group than in the control group at week 10. Plasma lactate levels after exercise in the 0.5% RGLE group were significantly lower than that in the control group. RGLE induced the upregulation of hormone-sensitive lipase mRNA in mesenteric adipose tissue, increased the plasma free fatty acid concentration after exercise, and enhanced fatty acid oxidation enzyme activity in the soleus muscle. Furthermore, peroxisome proliferator-activated receptor-gamma coactivator 1α (Pgc1α) and its downstream target genes were also significantly upregulated in the soleus muscle in the 0.5% RGLE group. Intake of RGLE upregulated Pgc1α expression and facilitated fatty acid oxidation in skeletal muscle, and these effects contributed, in part, to improve endurance capacity.

show abstract

“…A commercial preparation of GSE is available in the United States as a dietary supplement 15 . Doses up to 720 mg/day have been used in clinical studies 16 for evaluation of the effect of GSE in patients with chronic venous insufficiency. There are little or no side effects reported with GSE, and no drug interactions have been reported either.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women: A Pilot Study

Wahner‐Roedler

Bauer

Loehrer

et al. 2014

Journal of Dietary Supplements

View full text Add to dashboard Cite

Introduction The roll of estrogens in the pathogenesis of breast cancer is well documented and has lead to the development of Selective Estrogene Receptor Modulators and Aromatase Inhibitors for treatment and prevention of breast cancer. However these agents are associated with significant side effects and are therefore not well accepted by healthy women who are at high risk for breast cancer. There has been some evidence from in vitro and in vivo animal studies that grapes have an aromatase inhibiting effect resulting in a decrease in estrogen synthesis and increase in androstenedione and testosterone. Method We conducted a randomized, double-blind, dose finding early phase trial. Eligible partici-pants were randomly assigned to one of 4 doses of grape seed extract (200, 400, 600, or 800 mg) to be taken daily for 12 weeks. The primary outcome was the change of plasma hormone levels (estrogen conjugates from baseline to 12 weeks after treatment with grape seed extract). Results Forty-six women were enrolled, 39 (84.8%) completed the study. In this pilot study grape-seed extract given in daily doses of 200, 400, 600 or 800 mg for 12 weeks to postmenopausal women did not decrease plasma estrogens (estrone, estradiol, estrone sulfate) and did not increase precursors of androgens (testosterone and androstenedione). There were large variations in pre- and posttreatment estrone, estradiol and estrone sulfate and androgen precursors. Conclusion Future research should carefully consider BMI and changes in BMI as well as higher dosing of grape seed extract in their design.

show abstract

Efficacy of Orally Administered Extract of Red Vine Leaf AS 195 (folia vitis viniferae) in Chronic Venous Insufficiency (Stages l-ll)

Cited by 46 publications

References 11 publications

Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts

Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts

Red grape leaf extract improves endurance capacity by facilitating fatty acid utilization in skeletal muscle in mice

The Effect of Grape Seed Extract on Estrogen Levels of Postmenopausal Women: A Pilot Study

Contact Info

Product

Resources

About