Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats

Matsunami, Tamaki; Hino, Kazuo; Dosho, Rie; Miyatake, Sho; Ebisu, Goro; Kuwatsuru, Ryohei

doi:10.1007/s11604-017-0620-4

Cited by 4 publications

(4 citation statements)

References 19 publications

(16 reference statements)

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“…fluids when patients stratified by severity of CKD. Finally, Matsunami et al [15] compared the effects of i.v. saline to an oral rehydration solution (50 meq sodium) in a rat model of contrast nephrotoxicity; both were similarly effective in mitigating the fall in creatinine clearance and renal histologic injury compared with controls.…”

Section: Oral Hydrationmentioning

confidence: 99%

“…The theoretical rationale for fluid administration prophylaxis includes a reduction in vasoconstrictive hormones, increased sodium diuresis with a decrease in tubuloglomerular feedback, prevention of tubular obstruction, protection against reactive oxygen species (ROS) injury and dilution of intratubular contrast media minimizing direct tubular toxicity [8,11]. The use of fluid administration is supported by multiple animal studies evaluating the role of volume contraction in the pathogenesis of contrast media nephrotoxicity [12][13][14][15]16 & ,17 -19].…”

Section: Historical Basis Of Fluid Administation Prophylactic Strategiesmentioning

confidence: 99%

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Fluid administration strategies for the prevention of contrast-associated acute kidney injury

Rudnick

Fay

Wahba

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThe known timing of contrast media exposure in patients identified as high-risk for contrast-associated acute kidney injury (CA-AKI) enables the use of strategies to prevent this complication of intravascular contrast media exposure. Although multiple preventive strategies have been proposed, periprocedural fluid administration remains as the primary preventive strategy. This is a critical review of the current evidence evaluating a variety of fluid administration strategies in CA-AKI.Recent findingsFluid administration strategies to prevent CA-AKI include comparisons of intravenous (i.v.) to no fluid administration, different fluid solutions, duration of fluid administration, oral hydration, left ventricular end diastolic-pressure guided fluid administration and forced diuresis techniques.SummaryDespite an abundance of fluid administration trials, it is difficult to make definitive recommendations about preventive fluid administration strategies due to low scientific quality of published studies. The literature supports use of i.v. compared with no fluid administration, especially in high-risk patients undergoing intra-arterial contrast media exposure. Use of isotonic saline is recommended over 0.45% saline or isotonic sodium bicarbonate. Logistical considerations support shortened over longer i.v. fluid administration strategies, despite an absence of evidence of equivalent efficacy. Current literature does not support oral hydration for high-risk patients. The use of tailored fluid administration in heart failure patients and forced diuresis with matching fluid administration are promising new fluid administration strategies.

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Section: Oral Hydrationmentioning

confidence: 99%

Section: Historical Basis Of Fluid Administation Prophylactic Strategiesmentioning

confidence: 99%

Fluid administration strategies for the prevention of contrast-associated acute kidney injury

Rudnick

Fay

Wahba

2022

Current Opinion in Nephrology &Amp; Hypertension

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“…At the same time, hydration can reduce the concentration of CM in renal tubules, so as to ameliorate the direct damage of CM to renal tubule epithelial cells [39]. Hydration can be administered orally or intravenously, both of which have been reported to be effective in preventing CIN [40]. However, intravenous hydration is more clinically acceptable than the oral one due to its quantifiable operability.…”

Section: Prevention Of Cin Personalized Hydrationmentioning

confidence: 99%

Acute Kidney Injury in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Pathophysiologies, Risk Factors, and Preventive Measures

et al. 2021

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Background: Percutaneous coronary intervention (PCI) has been an effective treatment for acute coronary syndrome (ACS) patients. Acute kidney injury (AKI) is one of the common complications after PCI, which seriously affects the living quality and survival time of patients. The approach followed for the patient with AKI after PCI depends on the clinical context and may vary by resource availability. Summary: This review focuses on the pathophysiologies, influencing factors, and preventive measures of AKI in patients with ACS after PCI. The knowledge may better serve the patients and improve their outcomes. Key Messages: Many studies have been carried out for the definition and standard of AKI in the past few years. Etiologies of AKI after PCI included renal damage of contrast medium and atherosclerotic embolism, cardiac insufficiency and surgical factors on renal function. Basic conditions, treatment modalities, and perioperative changes are major risk factors of AKI. Studies have reported that the prevention of contrast-induced nephropathy, mod-ulating the volume overload, some pharmaceuticals and blood purification treatment are helpful to prevent the occurrence of AKI.

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“…Studies reported the preventive effects of adrenomedullin, Enalapril maleate, Folic acid and Pioglitazone through its vasodilatory and anti-inflammatory properties, so can prevent the development of CIN [6] . Some authors stated that oral rehydration solution with saline infusion or Statins administration can prevent CIN [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Deleterious Effect of Urografin on the Renal Tubules of Adult Albino Rats and the Possible Protective Effect of N-Acetylcysteine Light and Electron Microscopic Study

Amer

Elabd

2019

Egyptian Journal of Histology

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Introduction: Urografin (UG) is one of several types of contrast media used through the extensive use of investigations as imaging and interventional procedures. Multiple complications were encountered from its usage especially kidney affection, in a condition described as Contrast-induced nephropathy (CIN) which may be prevented with the antioxidant N-Acetylcysteine (NAC). Aim of the work:To study the effect of Urografin on the renal tubules of albino rats and evaluate the role of N-Acetylcysteine administration on the injured tubules. Materials and Methods: Twenty four adult albino rats were used regardless sex and were divided into 4 groups; a control group, NAC group by its administration in a dose equivalent to the human dose twice daily, Urografin group; where rats received a high dose of Urografin76% solution through rat tail vein infusion and UG + NAC group; where rats received the same dose of Urografin 76% and NAC. The obtained specimens were examined by both light and electron microscopy. Results: NAC group showed the same normal histological picture of renal tubules as the control group I. Renal sections of UG group revealed tubular dilatation with the presence of cellular debris in their lumens. Some tubules showed destruction and displayed highly vacuolated cytoplasm and dark pyknotic nuclei. Ultrastructurally, damaged apical membrane with partial loss of microvilli and rarefaction of the cytoplasm were noticed. UG + NAC group showed evidence of improvement as compared to UG group. Most of the tubules showed a nearly normal histological picture except for a few dilated ones with cellular debris. Conclusion: N-Acetylcysteine exerts a protective effect against renal tubular damage of the kidney that has been induced by Urografin injection. So, it may be a useful protective agent before and during imaging procedures.

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Efficacy of oral supplemental hydration for the prevention of contrast-induced nephropathy in rats

Abstract: Both intravenous saline administration and oral hydration with ORS decreased the severity of CIN. Hydration with ORS was comparable to intravenous saline infusion in preventing CIN-associated abnormalities.

Cited by 4 publications

References 19 publications

Fluid administration strategies for the prevention of contrast-associated acute kidney injury

Fluid administration strategies for the prevention of contrast-associated acute kidney injury

Acute Kidney Injury in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: Pathophysiologies, Risk Factors, and Preventive Measures

Deleterious Effect of Urografin on the Renal Tubules of Adult Albino Rats and the Possible Protective Effect of N-Acetylcysteine Light and Electron Microscopic Study

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