Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey

Crimean-Congo Haemorrhagic Fever: Treatment and Use of Ribavirin

“…Ribavirinin yararlı olmadığını ifade eden bir çalışmada, ribavirin alan grupta ölüm oranı %7, almayan grupta %12 olarak bildirilmiş, ancak yeterli örneklem büyüklüğüne ulaşılamadığı için istatistiksel anlamlılık gösterilememiştir (38). Buradan yola çıkarak, ribavirinin etkisinin tartışmalı olduğu-nu iddia etmek doğru bir yaklaşım değildir.…”

Crimean-Congo Hemorrhagic Fever

“…An in vitro study showed that ribavirin inhibited viral activity and some strains of CCHFV were more susceptible than others; however, the efficacy of ribavirin in CCHF treatment has not been proven. Although some retrospective clinical studies have reported that ribavirin affects prognosis positively, there are also studies with contradictory findings [61,[87][88][89][90][91][92] . Results of a single randomized controlled study conducted in Turkey suggested that ribavirin was ineffective [91] .…”

Data collection for risk assessments on animal health (Acronym: DACRAH) : Final Report

“…(Mardani et al, 2003) Measures of efficacy varied between studies from 0.34 (95% 0.02-0.55) to 0.80 (0.55-0.91) (Koksal et al, 2010) There was no positive effect determined on clinical and laboratory parameters in CCHF patients treated with ribavirin. (Elaldi et al, 2009;SharifiMood et al, 2006) Mixed effects of ribavirin on case mortality rates are also reported. (Cevik et al, 2008) Intravenous 4 of the 9 CCHF patients given ribavirin were still alive 10 days after treatment.…”