Efficacy of Oral Amoxicillin versus Parenteral Ceftriaxone in Treatment of Uncomplicated Community Acquired Pneumonia (CAP): A Prospective, Single Blinded, Parallel Design, Randomized Controlled Trial

Pustake, Manas; Mane, Sushant; Sathe, Vaijnath; Walhekar, Sagar; Ramakrishnan, Sharanya

doi:10.7199/ped.oncall.2021.13

Cited by 1 publication

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recent UK CAP-IT trial found that lower doses of amoxicillin, of 35 to 50 mg/kg per day instead of high dose of 70 to 90 mg/kg per day, and shorter duration (3 days instead of 7 days) were non-inferior in cases of non-severe pediatric community-acquired pneumonia in settings with a low prevalence of pneumococcal resistance [19]. Amoxicillin has been widely studied and was found to be effective in short durations in community-acquired pneumonia management in the low-middle income countries (Table 3) [20][21][22][23][24].…”

Section: Community-acquired Pneumoniamentioning

confidence: 99%

See 1 more Smart Citation

Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections

Dharmapalan

Bielicki

2023

Antibiotics

View full text Add to dashboard Cite

Pediatric guidelines vary in their recommended amoxicillin dosing for common respiratory infections. It would help program delivery if there was harmonization of dosing and formulation of amoxicillin across multiple clinical respiratory infections, considering the pharmacokinetics, common targets, drug resistance, availability, cost effectiveness, and ease of administration. The World Health Organization EML AWaRe Book recommends higher dose amoxicillin given twice daily for five days for all uncomplicated respiratory infections where an antibiotic is indicated. The WHO AWaRe Book amoxicillin dosing guidance can be achieved for infants and older children using only scored 250 mg and 500 mg dispersible tablets (DTs), the WHO recommended child formulation. There is a clear need for wider availability of 250 mg/500 mg dispersible tablets of amoxicillin in both public and private health care sectors, to improve access to essential antibiotics.

show abstract

Section: Community-acquired Pneumoniamentioning

confidence: 99%

“…Randomized control trials on amoxicillin in community-acquired pneumonia from lowmiddle income settings, published between 2020 and 2022[20][21][22][23][24].…”

mentioning

confidence: 99%

Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections

Dharmapalan

Bielicki

2023

Antibiotics

View full text Add to dashboard Cite

show abstract

Efficacy of Oral Amoxicillin versus Parenteral Ceftriaxone in Treatment of Uncomplicated Community Acquired Pneumonia (CAP): A Prospective, Single Blinded, Parallel Design, Randomized Controlled Trial

Cited by 1 publication

References 29 publications

Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections

Harmonization of Amoxicillin Dose, Duration, and Formulation for Acute Childhood Respiratory Infections

Contact Info

Product

Resources

About