Efficacy of oral administration of ascofuranone with and without glycerol against Trypanosoma congolense

Yamazaki, Ai; Suganuma, Keisuke; Tanaka, Yusuke; Watanabe, Kenichi; Kawazu, Shin-ichiro; Kita, Kiyoshi; Inoue, Noboru

doi:10.1016/j.exppara.2023.108588

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies on T. vivax trypanosome species were conducted in in vivo laboratory models; however, very few strains of the same have been isolated that readily infect rodents, and most published in vivo work on this species comprises the very few mouse-infective strains, the main one being T. vivax Y486 and its derivatives (Gibson 2012 ). Against this backdrop, the isolate used in the study was rodent-adapted which would have originated from Nigeria (Yamazaki et al 2023 ) and the AF effectively cured the experimentally infected calves.…”

Section: Discussionmentioning

confidence: 99%

Ascofuranone antibiotic is a promising trypanocidal drug for nagana

Suganuma,

Mochabo,

Chemuliti

et al. 2024

Onderstepoort Journal of Veterinary Research

Self Cite

View full text Add to dashboard Cite

Trypanosomosis is a disease complex which affects both humans and animals in sub-Saharan Africa, transmitted by the tsetse fly and distributed within the tsetse belt of Africa. But some trypanosome species, for example, Trypanosoma brucei evansi, T. vivax, T. theileri and T. b. equiperdum are endemic outside the tsetse belt of Africa transmitted by biting flies, for example, Tabanus and Stomoxys, or venereal transmission, respectively. Trypanocidal drugs remain the principal method of animal trypanosomosis control in most African countries. However, there is a growing concern that their effectiveness may be severely curtailed by widespread drug resistance. A minimum number of six male cattle calves were recruited for the study. They were randomly grouped into two ( T. vivax and T. congolense groups) of three calves each. One calf per group served as a control while two calves were treatment group. They were inoculated with 10 5 cells/mL parasites in phosphate buffered solution (PBS) in 2 mL. When parasitaemia reached 1 × 10 7.8 cells/mL trypanosomes per mL in calves, treatment was instituted with 20 mL (25 mg/kg in 100 kg calf) ascofuranone (AF) for treatment calves, while the control ones were administered a placebo (20 mL PBS) intramuscularly. This study revealed that T. vivax was successfully cleared by AF but the T. congolense group was not cleared effectively. Contribution There is an urgent need to develop new drugs which this study sought to address. It is suggested that the AF compound can be developed further to be a sanative drug for T. vivax in non-tsetse infested areas like South Americas.

show abstract

Section: Discussionmentioning

confidence: 99%

Ascofuranone antibiotic is a promising trypanocidal drug for nagana

Suganuma,

Mochabo,

Chemuliti

et al. 2024

Onderstepoort Journal of Veterinary Research

Self Cite

View full text Add to dashboard Cite

show abstract

New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides

Chemutai,

Gonkhom,

Ibrahim

et al. 2023

Preprint

View full text Add to dashboard Cite

Preparative high performance liquid chromatography (HPLC) purification of the ethyl acetate extracts derived from dried basidiomes of the European mushroom Hericium coralloides led to the identification of two previously undescribed isoindolinone derivatives named corallocins D and E (1–2). The structures of the compounds were elucidated based on HR-ESIMS (high-resolution electron spray ionization mass spectroscopy), interpretation of 1D and 2D NMR spectra, circular dichroism (CD) experiments, and comparisons with published and theoretical data. The metabolites were tested for their cytotoxic and antimicrobial effects in vitro where weak to moderate biological effects were observed against HeLa cells (KB 3.1), Mucor hiemalis and Bacillus subtilis.

show abstract

Efficacy of oral administration of ascofuranone with and without glycerol against Trypanosoma congolense

Cited by 2 publications

References 18 publications

Ascofuranone antibiotic is a promising trypanocidal drug for nagana

Ascofuranone antibiotic is a promising trypanocidal drug for nagana

New isoindolinone derivatives isolated from the fruiting bodies of the basidiomycete Hericium coralloides

Contact Info

Product

Resources

About