Efficacy of omalizumab in chronic spontaneous urticaria associated with chronic inducible urticaria

Dortas, Sérgio Duarte; Azizi, Guilherme Gomes; Valle, Solange Oliveira Rodrigues

doi:10.1016/j.anai.2020.06.011

Cited by 4 publications

(4 citation statements)

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“…The therapeutic response is variable to antihistamines and the use of quadrupled doses is often necessary. Omalizumab, dapsone, sulfasalazine, anti-TNF, and theophylline have also been used to control DPU symptoms [54,57,58].…”

Section: Hucff-ufrj Immunology Service Courtesymentioning

confidence: 99%

“…Different therapeutic modalities were described, according to the intensity of the symptoms: sunscreen, oral antihistamines, cyclosporine, desensitization with different types of phototherapy, omalizumab, plasmapheresis, Intravenous Immunoglobulin (IgIV), afamelanotide, among others. Although therapeutic recommendations have been proposed in the context of chronic urticarias, there are no consensus--based guidelines that define the specific approach for solar urticarial [54,57].…”

Section: Hucff-ufrj Immunology Service Courtesymentioning

confidence: 99%

“…Aquagenic urticaria is uncommon and represents a body's reaction to water; this is independent of temperature. H1 antihistamines and UV therapy are used to treat this disease with variable response [54,57].…”

Section: Hucff-ufrj Immunology Service Courtesymentioning

confidence: 99%

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Síndromes imunológicas e alérgicas induzidas ou exacerbadas por exercício: o que o profissional de saúde do exercício precisa saber sobre doenças imunoalérgicas e esporte?

Júnior

Azizi

2021

Rev Bras Fisiol Exerc

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As doenças imunoalérgicas induzidas ou exacerbadas pelo exercício são situações significativamente importantes tanto para atletas amadores quanto profissionais. Asma, broncoespasmo, laringoespasmo e anafilaxia induzidos pelo exercício, urticárias induzidas e angioedema hereditário são exemplos destas situações. O objetivo deste artigo é contribuir para o conhecimento de profissionais de saúde com orientação ao manejo de distúrbios de hipersensibilidade induzidos por exercícios ou desencadeados durante a prática esportiva, para permitir que seus pacientes realizem, com segurança, as atividades relacionadas ao exercício.

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Section: Hucff-ufrj Immunology Service Courtesymentioning

confidence: 99%

Section: Hucff-ufrj Immunology Service Courtesymentioning

confidence: 99%

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Síndromes imunológicas e alérgicas induzidas ou exacerbadas por exercício: o que o profissional de saúde do exercício precisa saber sobre doenças imunoalérgicas e esporte?

Júnior

Azizi

2021

Rev Bras Fisiol Exerc

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“…There are different types of chronic urticaria, usually divided into spontaneous and inducible urticaria. [ 5 , 6 ] Among them, chronic spontaneous urticaria (CSU) is the most common clinical type of chronic urticaria. [ 7 ] CSU is marked by severe itching, often recrudescent, and the course is often long and unpredictable.…”

Section: Introductionmentioning

confidence: 99%

Moxibustion therapy for chronic spontaneous urticaria

2020

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Background: Chronic spontaneous urticaria (CSU) is a common disease in clinical, and often recrudescent. However, sometimes Western medicine treatments such as antihistamines cannot completely control the symptoms of CSU; therefore, more effective and optimized treatments are needed. Numerous studies have confirmed that moxibustion therapy is effective in treating CSU. Given that no relevant systematic reviews and meta-analysis have been carried out, we set out to prove the effect of moxibustion therapy for CSU. Methods: This protocol will be conducted based on the PRISMA-P guidelines and comply with the recommendations of the Cochrane Collaboration Handbook for Systematic Reviews. We plan to search the subsequent databases: PubMed, Web of Science, EMBASE.com and Cochrane Library, China National Knowledge Infrastructure, WanFang Database, Chinese Science Journal Database, and China Biomedical Literature Database. The studies will be screened under the eligibility criterion. The quality of the studies will be assessed based on the Cochrane risk bias tool. Ultimately, Review Manager 5.3 will be used for statistical analysis. Results: This research will comprehensively evaluate the effectiveness of moxibustion therapy for CSU, and provide a more reasonable and effective treatment plan for CUS. Conclusion: This research will bring new evidence for the efficacy of moxibustion therapy in the treatment of CSU and provide a basis for future clinical applications. Inplasy registration number: INPLASY2020100045

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Omalizumab in the treatment of various forms of chronic urticaria

Olisova

Скандер

2023

Russian Journal of Skin and Venereal Diseases

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BACKGROUND: Chronic urticaria is a skin disease characterized by the appearance of itchy weals and/or angioedema for 6 or more weeks. Chronic urticaria is subdivided into chronic spontaneous urticaria, which occurs due to an unknown cause, and chronic inducible urticaria, which occurs as a result of exposure to various physical factors (water, cold, heat, pressure, mechanical irritation), can occur simultaneously or independently of each other. Omalizumab, anti-IgE monoclonal antibody, is approved for the treatment of patients with chronic spontaneous urticaria and is the second choice in cases of resistance to antihistamine treatment. In patients with a combination of chronic spontaneous urticaria and chronic inducible urticaria, the effectiveness of treatment with omalizumab has been little studied. AIM: compare the effectiveness of omalizumab treatment in patients with chronic spontaneous urticaria and patients with a combination of chronic spontaneous and chronic induced urticaria. MATERIALS AND METHODS: Under supervision there were 30 patients with chronic spontaneous urticaria and combined chronic spontaneous and inducible urticaria (15 patients in each group). Evaluation of the effectiveness of treatment was carried out according to the results of the questionnaires DLQI (dermatological index of quality of life), CU-Q2oL (questionnaire for quality of life in chronic urticaria), UCT (urticaria control test), UAS (urticaria activity scale), HADS (Hospital Anxiety and Depression Scale) and provocation tests in dynamics before and during treatment. RESULTS: All patients received omalizumab 300 mg subcutaneously once a month for 6 to 12 months. After the first injection of omalizumab, we noted a decrease in the severity of urticaria, an increase in the level of disease control and quality of life when comparing parameters before and during treatment in more than 90% of patients. Improved performance remained at this level throughout all subsequent months of treatment. CONCLUSION: Omalizumab is equally effective in patients with an isolated form of chronic spontaneous urticaria and in patients with a combined form of chronic spontaneous and inducible urticaria. The use of omalizumab allows you to control the symptoms of chronic spontaneous and inducible urticaria, even with prolonged use.

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Efficacy of omalizumab in chronic spontaneous urticaria associated with chronic inducible urticaria

Cited by 4 publications

References 10 publications

Síndromes imunológicas e alérgicas induzidas ou exacerbadas por exercício: o que o profissional de saúde do exercício precisa saber sobre doenças imunoalérgicas e esporte?

Síndromes imunológicas e alérgicas induzidas ou exacerbadas por exercício: o que o profissional de saúde do exercício precisa saber sobre doenças imunoalérgicas e esporte?

Moxibustion therapy for chronic spontaneous urticaria

Omalizumab in the treatment of various forms of chronic urticaria

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