Efficacy of Oleuropein Aglycone in the Treatment of Transthyretin-Amyloidosis

Leri, Manuela; Bucciantini, Monica

doi:10.21767/2471-8084.100011

Cited by 1 publication

(1 citation statement)

References 35 publications

(39 reference statements)

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“…In addition, it may also hinder the binding of α‐synuclein aggregates to cell membrane components thus preventing cell oxidative damage (Palazzi et al., 2018). Leri and Bucciantini (2016) reported that oleuropein aglycone could inhibit the toxic effects of transthyretin (TTR) amyloid and be important to prevent or treat heart and liver complications. It has also been shown to be capable of preventing or delaying the progression of type 2 diabetes (Rigacci et al., 2010) and obesity (Oi‐Kano et al., 2017).…”

Section: Applications Of the Main Bioactive Compounds Extracted From ...mentioning

confidence: 99%

Applications of bioactive compounds extracted from olive industry wastes: A review

Madureira

Margaça

Santos‐Buelga

et al. 2021

Comp Rev Food Sci Food Safe

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The wastes generated during the olive oil extraction process, even if presenting a negative impact for the environment, contain several bioactive compounds that have considerable health benefits. After suitable extraction and purification, these compounds can be used as food antioxidants or as active ingredients in nutraceutical and cosmetic products due to their interesting technological and pharmaceutical properties. The aim of this review, after presenting general applications of the different types of wastes generated from this industry, is to focus on the olive pomace produced by the two‐phase system and to explore the challenging applications of the main individual compounds present in this waste. Hydroxytyrosol, tyrosol, oleuropein, oleuropein aglycone, and verbascoside are the most abundant bioactive compounds present in olive pomace. Besides their antioxidant activity, these compounds also demonstrated other biological properties such as antimicrobial, anticancer, or anti‐inflammatory, thus being used in formulations to produce pharmaceutical and cosmetic products or in the fortification of food. Nevertheless, it is mandatory to involve both industries and researchers to create strategies to valorize these byproducts while maintaining environmental sustainability.

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