Efficacy of Octacalcium Phosphate Collagen Composite for Titanium Dental Implants in Dogs

Abstract

Background: Previous studies showed that octacalcium (OCP) collagen composite (OCP/Col) can be used to repair human jaw bone defects without any associated abnormalities. The present study investigated whether OCP/Col could be applied to dental implant treatment using a dog tooth extraction socket model. Methods: The premolars of dogs were extracted; each extraction socket was extended, and titanium dental implants were placed in each socket. OCP/Col was inserted in the space around a titanium dental implant. Autologous bone was used to fill the other sockets, while the untreated socket (i.e., no bone substitute material) served as a control. Three months after the operation, these specimens were analyzed for the osseointegration of each bone substitute material with the surface of the titanium dental implant. Results: In histomorphometric analyses, the peri-implant bone areas (BA%) and bone-implant contact (BIC%) were measured. There was no difference in BA% or BIC% between OCP/Col and autologous bone. Conclusion: These results suggested that OCP/Col could be used for implant treatment as a bone substitute.

First clinical application of octacalcium phosphate collagen composite on bone regeneration in maxillary sinus floor augmentation: A prospective, single‐arm, open‐label clinical trial

“…osseointegration to autologous bone graft in a study of the mandible in a canine model. 25 On the other hand, the ISQ value showed no significant difference between the two time points under the simultaneous approach, but was high enough at the initial operation, meaning that implant stability was obtained by the remaining host bone.…”

“…The value increased from 59.5 at implant placement to 72.0, indicating the completion of osseointegration at the second operation, 6 months after the initial operation, using the staged approach [Figure (c)]. OCP/Col graft around the implants is also reported achieving comparable osseointegration to autologous bone graft in a study of the mandible in a canine model . On the other hand, the ISQ value showed no significant difference between the two time points under the simultaneous approach, but was high enough at the initial operation, meaning that implant stability was obtained by the remaining host bone.…”

Clinical study of octacalcium phosphate and collagen composite in oral and maxillofacial surgery

“…The results in these studies indicated the following: OCP/Col can be converted to normal bone tissue in critical-sized bone defects in the calvarium without remaining as a foreign body, 25,26 OCP/Col can retain the shape of the alveolar bone after tooth extraction without bone resorption, 27 the gap in the alveolar bone cleft can be filled with newly formed bone after OCP/Col implantation, 28,29 a permanent tooth can normally erupt in the newly formed bone after OCP/Col implantation in the extraction socket of deciduous teeth, 30 OCP/Col can facilitate bone augmentation in the mandibular alveolar bone defect with titanium mesh, 31 and newly formed bone after OCP/Col implantation can have the same osseointegration for titanium dental implant surfaces as autologous bone. 32 The first clinical application of OCP/Col has been conducted in the bone defect caused by tooth extraction or cystectomy in 10 patients in a clinical study of bone regenerative therapy by OCP/Col composites (registered with JPRN-UMIN000004655 in the University Hospital Medical Information Network in Japan (UMIN) and International Clinical Trials Registry Platform Search Portal of the World Health Organization, from 2011 to 2013 at Tohoku University Hospital), 33,34 as a preclinical trial. The first objective of this study was to investigate the safety of OCP/ Col in clinical use.…”

Scaffold-Mediated Gene Delivery for Osteochondral Repair

“…Inorganic materials like hydroxyapatite (HAp) have been mostly used in bone regeneration approaches, due to its exceptional mechanical stiffness and osteoinductivity [ 74 , 76 ]. Metallic scaffolds based on tantalum or titanium are also used as subchondral bone substitutes alone or in combination with other biomaterials in composite scaffolds [ 95 , 96 , 97 ]. Their lack of degradation and the possibility of releasing corrosion products are concerns to be considered [ 74 ].…”