Efficacy of nonsteroidal antiinflammatory medications for prevention of atrial fibrillation following coronary artery bypass surgery

Cheruku, Kiran K.; Ghani, Abdul; Ahmad, Faheem; Pappas, Patroklos; Silverman, Paul; Zellinger, Allan; Silver, Marc A.

doi:10.1016/s0735-1097(02)80450-8

Cited by 7 publications

(4 citation statements)

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“…7 Recently studies have shown that the use of antiinflammatory agents is associated with a decreased incidence of AF. In a recent study by Cheruku et al, 12 the use of the nonsteroidal anti-inflammatory drug ketolorac significantly reduced AF after coronary artery bypass grafting. This was attributed to a decrease in inflammation caused by the nonsteroidal anti-inflammatory drug.…”

Section: Discussionmentioning

confidence: 93%

“…This was attributed to a decrease in inflammation caused by the nonsteroidal anti-inflammatory drug. 12 Statins, which have been shown to decrease inflammation, 13 also decreased the incidence of AF in recent studies in both animal models and humans. [14][15][16][17] In addition, recent studies have shown that angiotensin converting enzyme inhibitors may decrease the incidence of AF in patients with reduced left ventricular ejection fraction.…”

Section: Discussionmentioning

confidence: 99%

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C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion

Wazni

Martin

Marrouche

et al. 2005

Heart

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Background: To test the hypothesis that a high C reactive protein (CRP) concentration would predict recurrence of atrial fibrillation (AF) after cardioversion in patients taking antiarrhythmic drugs. Methods: 111 patients who underwent direct current cardioversion for symptomatic AF were enrolled. Blood was drawn for CRP determination before cardioversion on the same day. All patients were taking antiarrhythmic drugs before and after electrical cardioversion. Results: After a mean follow up of 76 days, 75 patients had recurrence of AF. In univariate analysis, the median CRP concentration was significantly higher in patients with AF recurrence (3.95 mg/l v 1.81 mg/l, p = 0.002). Among the 55 patients with CRP in the upper 50th centile, 44 (80%) experienced recurrence of AF over a total follow up of 8.98 patient years, whereas among the 56 patients with CRP in the lower 50th centile, 31 (55%) experienced recurrence of AF over a total follow up of 14.3 patient years (p , 0.001). The adjusted hazard ratio comparing the upper 50th centile of CRP with the lower 50th centile of CRP was 2.0 (95% confidence interval 1.2 to 3.2, p = 0.007). Conclusions: CRP is independently associated with recurrence of AF after electrical cardioversion among patients taking antiarrhythmic drugs. These results suggest that inflammation may have a role in the pathogenesis of AF resistant to antiarrhythmic drugs.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion

Wazni

Martin

Marrouche

et al. 2005

Heart

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“…Based on these findings, some investigators have evaluated whether anti-inflammatory interventions as statins, carvedilol, oral glucocorticoids, nonsteroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors and oral vitamin C have favourable effects on the prevention of atrial fibrillation development and recurrence [3,[9][10][11][12][13][14]. They have reported promising findings regarding the effectiveness of these anti-inflammatory interventions.…”

Section: Dear Editormentioning

confidence: 99%

The impact of inflammation on the development, successful cardioversion, recurrence and/or perpetuation of atrial fibrillation

Turhan

Aksoy

Yetkın

et al. 2007

International Journal of Cardiology

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“…These include specific and non specific anti inflammatory agents such as glucocorticoids, non steroid anti inflammatory drugs, statins and vitamin C. Moreover, ACE inhibitors and ARBs that protect from neurohumoral activation and tissue damage have been also reported to afford protection for the recurrence of the arrhythmia [16][17][18][19][20][21][22].…”

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confidence: 99%

Response of letter to the Editor: “The impact of inflammation on the development, successful cardioversion, recurrence and/or perpetuation of atrial fibrillation”, by Dr Hasan Turhan et al.

Corbalán

2007

International Journal of Cardiology

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Efficacy of nonsteroidal antiinflammatory medications for prevention of atrial fibrillation following coronary artery bypass surgery

Cited by 7 publications

References 0 publications

C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion

C reactive protein concentration and recurrence of atrial fibrillation after electrical cardioversion

The impact of inflammation on the development, successful cardioversion, recurrence and/or perpetuation of atrial fibrillation

Response of letter to the Editor: “The impact of inflammation on the development, successful cardioversion, recurrence and/or perpetuation of atrial fibrillation”, by Dr Hasan Turhan et al.

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