Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis

Nissim, Nicole R.; Moberg, Paul J.; Hamilton, Roy H.

doi:10.3390/brainsci10090597

Cited by 51 publications

(44 citation statements)

References 82 publications

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“…Without disease-modifying therapies, non-pharmacological approaches to PPA management are of considerable importance, and non-invasive brain stimulation techniques to ameliorate specific symptoms across PPA variants have received much recent attention. Transcranial direct current stimulation as an adjunct to traditional speech and language therapy has shown some promise in PPA [87,88], and there have been some reports of success with transcranial magnetic stimulation in case studies and small cohorts [89][90][91]; clinical trials are currently underway.…”

Section: The Challenge Of Treatment: Optimising Function and Changingmentioning

confidence: 99%

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

Ruksenaite

Volkmer

Jiang

et al. 2021

Curr Neurol Neurosci Rep

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Purpose of Review The term primary progressive aphasia (PPA) refers to a diverse group of dementias that present with prominent and early problems with speech and language. They present considerable challenges to clinicians and researchers. Recent Findings Here, we review critical issues around diagnosis of the three major PPA variants (semantic variant PPA, nonfluent/agrammatic variant PPA, logopenic variant PPA), as well as considering ‘fragmentary’ syndromes. We next consider issues around assessing disease stage, before discussing physiological phenotyping of proteinopathies across the PPA spectrum. We also review evidence for core central auditory impairments in PPA, outline critical challenges associated with treatment, discuss pathophysiological features of each major PPA variant, and conclude with thoughts on key challenges that remain to be addressed. Summary New findings elucidating the pathophysiology of PPA represent a major step forward in our understanding of these diseases, with implications for diagnosis, care, management, and therapies.

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Section: The Challenge Of Treatment: Optimising Function and Changingmentioning

confidence: 99%

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

Ruksenaite

Volkmer

Jiang

et al. 2021

Curr Neurol Neurosci Rep

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“…It is known that gamma oscillatory activity is abnormal in AD patients [106]. Gamma activity has been linked to cortico-cortical communication, multisensory processing and integration across different brain regions [66,107]. For this reason, Naro et al [108] stimulated six different regions in the left hemisphere using tACS to evaluate gamma frequency entraining in AD, MCI and healthy participants.…”

Section: Transcranial Alternating Current Stimulation-tacsmentioning

confidence: 99%

“…NIBS techniques have only recently been applied to PPA treatments. The increasing evidence about the efficacy of neurostimulation techniques in treating neurodegenerative disorders can be inferred by the growing number of studies, reviews and meta-analyses published in recent years [107,116]. However, most of the studies in the literature adopted rTMS or anodal tDCS with or without language training.…”

Section: Frontotemporal Dementiamentioning

confidence: 99%

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

2021

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Background and Objectives: Neurodegenerative diseases that typically affect the elderly such as Alzheimer’s disease, Parkinson’s disease and frontotemporal dementia are typically characterised by significant cognitive impairment that worsens significantly over time. To date, viable pharmacological options for the cognitive symptoms in these clinical conditions are lacking. In recent years, various studies have employed neuromodulation techniques to try and contrast patients’ decay. Materials and Methods: We conducted an in-depth literature review of the state-of-the-art of the contribution of these techniques across these neurodegenerative diseases. Results: The present review reports that neuromodulation techniques targeting cognitive impairment do not allow to draw yet any definitive conclusion about their clinical efficacy although preliminary evidence is very encouraging. Conclusions: Further and more robust studies should evaluate the potentialities and limitations of the application of these promising therapeutic tools to neurodegenerative diseases.

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“…[193][194][195][196][197][198][199][200][201][202][203][204][205][206][207][208] In a recent meta-analysis, tDCS was shown to be more effective than rTMS in the treatment of PPA. 209 Overall, the meta-analysis suggested significant benefits of both methods in PPA patients, with the optimal treatment protocol remaining unknown.…”

Section: Transcranial Direct and Alternate Current Stimulationmentioning

confidence: 98%

Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration

Giunta¹,

Solje²,

Gardoni³

et al. 2021

JEP

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Frontotemporal dementia is a clinically, genetically and pathologically heterogeneous neurodegenerative disorder, enclosing a wide range of different pathological entities, associated with the accumulation of proteins such as tau and TPD-43. Characterized by a high hereditability, mutations in three main genes, MAPT, GRN and C9orf72, can drive the neurodegenerative process. The connection between different genes and proteinopathies through specific mechanisms has shed light on the pathophysiology of the disease, leading to the identification of potential pharmacological targets. New experimental strategies are emerging, in both preclinical and clinical settings, which focus on small molecules rather than gene therapy. In this review, we provide an insight into the aberrant mechanisms leading to FTLD-related proteinopathies and discuss recent therapies with the potential to ameliorate neurodegeneration and disease progression.

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Efficacy of Noninvasive Brain Stimulation (tDCS or TMS) Paired with Language Therapy in the Treatment of Primary Progressive Aphasia: An Exploratory Meta-Analysis

Cited by 51 publications

References 82 publications

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

Primary Progressive Aphasia: Toward a Pathophysiological Synthesis

A Scoping Review of Neuromodulation Techniques in Neurodegenerative Diseases: A Useful Tool for Clinical Practice?

Experimental Disease-Modifying Agents for Frontotemporal Lobar Degeneration

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