Efficacy of non-invasive brain stimulation in decreasing depression symptoms during the peripartum period: A systematic review

Pacheco, Francisca; Guiomar, Raquel; Brunoni, André R.; Buhagiar, Rachel; Evagorou, Olympia; Roca-Lecumberri, Alba; Poleszczyk, Anna; Berg, Mijke P. Lambregtse–van den; Caparrós-González, Rafael A.; Fonseca, Ana; Osório, Ana Alexandra Caldas; Soliman, Mahmoud; Ganho-Ávila, Ana

doi:10.1016/j.jpsychires.2021.06.005

Cited by 18 publications

(14 citation statements)

References 99 publications

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“…Even if the current pharmacological strategies involve the use of a wide range of drugs acting on different targets, the investigations on the mechanism of action of new molecules with antidepressant properties are still ongoing [ 32 , 33 , 34 , 35 ]. In addition to the above-mentioned therapies, non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS), transcranial electrical stimulation (TES), and electroconvulsive therapy (ECT), acting on cortical excitability, have been proposed to obtain long-lasting effects on depressive symptoms in patients that do not respond to standard interventions [ 36 ]. NIBS were able to specifically modulate the abnormal activity of neural circuits in the amygdala, the medial prefrontal cortex and the hippocampus, and, consequently, the cognitive functions related to the memory acquisition and consolidation in depression and anxiety disorders [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice

Pignataro

Dicarlo

Zerlotin

et al. 2022

IJMS

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Depression is a psychiatric disorder increasingly diffused worldwide. Evidence suggests that irisin, a myokine secreted by contracting muscle, mediates beneficial effects on several targets, including the brain. Here, the potential antidepressant properties of long-term intermittent systemic irisin administration (100 µg/kg/weekly for 1 month) were evaluated in mice by the Tail Suspension Test (TST), Forced Swim Test (FST), and Open Field Test (OFT). Furthermore, to deepen the molecular pathways underlying irisin treatment, the expression of irisin precursor, neurotrophic/growth factors, and cytokines was analyzed. Irisin treatment significantly decreased the immobility time in the TST and FST, suggesting an antidepressant effect. Additionally, irisin seemed to display an anxiolytic-like effect increasing the time spent in the OFT arena center. These findings were probably due to the modulation of endogenous brain factors as the gene expression of some neurotrophins, such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor (IGF-1), was upregulated only in irisin-treated mouse brain. Moreover, irisin modulated the expression of some cytokines (IL-1β, IL-4, IL-6, and IL-10). To the best of our knowledge, this is the first study demonstrating that the irisin antidepressant effect may be observed even with a systemic administration in mice. This could pave the way toward intriguing preclinical research in humans.

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Section: Discussionmentioning

confidence: 99%

Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice

Pignataro

Dicarlo

Zerlotin

et al. 2022

IJMS

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“…In the present study, pregnant and breastfeeding women had not been included, although rTMS in both pregnant women and breastfeeding women has not shown any additional side effects or harm compared to other adult populations (Al-Shamali et al, 2022;Cole et al, 2019). In fact, non-invasive brain stimulation, including tDCS could potentially be an important alternative treatment in peripartum depression (Cole et al, 2019;Pacheco et al, 2021). Future studies should consider researching tDCS within these populations and carefully consider if these exclusion criteria are necessary.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive home-based transcranial direct current stimulation treatment for major depression with real-time remote supervision: An open-label, single-arm feasibility study with long term outcomes

Woodham

Rimmer

Young

et al. 2022

Journal of Psychiatric Research

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“…The aims of our review were to identify available studies about tES during pregnancy and the postpartum period in order to investigate its efficacy and safety during the perinatal period. To our knowledge, several reviews have addressed this topic [ 56 , 57 , 58 ], but the present research has the advantage of including a larger number of studies independently of diagnosis and type of tES used. Thus, we highlighted the complete absence of available data on the use of tES in postpartum disorders and during breastfeeding, including postpartum depression.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, several authors point out that transcutaneous electrical nerve stimulation (TENS), with a strength of 100 mA, has been used safely in pregnancy for decades as pain relief during labor [ 49 , 68 ]. Compared to tES techniques, repetitive transcranial magnetic stimulation (rTMS) has been more widely studied in the perinatal period [ 57 , 58 , 69 , 70 , 71 ]. Kurzeck et al [ 56 ] emphasized that follow-up examinations of children exposed to rTMS during pregnancy revealed no delay in cognitive or motor development [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports

Laurin

Nard

Dalmont

et al. 2022

JCM

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Introduction: The perinatal period is an at-risk period for the emergence or decompensation of psychiatric disorders. Transcranial electrical stimulation (tES) is an effective and safe treatment for many psychiatric disorders. Given the reluctance to use pharmacological treatments during pregnancy or breastfeeding, tES may be an interesting treatment to consider. Our study aims to evaluate the efficacy and safety of tES in the perinatal period through a systematic literature review followed by three original case reports. Method: Following PRISMA guidelines, a systematic review of MEDLINE and ScienceDirect was undertaken to identify studies on tES on women during the perinatal period. The initial research was conducted until 31 December 2021 and search terms included: tDCS, transcranial direct current stimulation, tACS, transcranial alternating current stimulation, tRNS, transcranial random noise stimulation, pregnancy, perinatal, postnatal, and postpartum. Results: Seven studies reporting on 33 women during the perinatal period met the eligibility criteria. No serious adverse effects for the mother or child were reported. Data were limited to the use of tES during pregnancy in patients with schizophrenia or unipolar depression. In addition, we reported three original case reports illustrating the efficacy and safety of tDCS: in a pregnant woman with bipolar depression, in a pregnant woman with post-traumatic stress disorder (sham tDCS), and in a breastfeeding woman with postpartum depression. Conclusions: The results are encouraging, making tES a potentially safe and effective treatment in the perinatal period. Larger studies are needed to confirm these initial results, and any adverse effects on the mother or child should be reported. In addition, research perspectives on the medico-economic benefits of tES, and its realization at home, are to be investigated in the future.

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Efficacy of non-invasive brain stimulation in decreasing depression symptoms during the peripartum period: A systematic review

Cited by 18 publications

References 99 publications

Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice

Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice

Adjunctive home-based transcranial direct current stimulation treatment for major depression with real-time remote supervision: An open-label, single-arm feasibility study with long term outcomes

Efficacy and Safety of Transcranial Electric Stimulation during the Perinatal Period: A Systematic Literature Review and Three Case Reports

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