Efficacy of nicorandil treatment for prevention of contrast-induced nephropathy in high-risk patients undergoing cardiac catheterization: A prospective randomized controlled trial

Abstract

The findings revealed that oral nicorandil had substantial efficacy over hydration protocol for the development of CIN in high-risk patients undergoing cardiac catheterization.

Nicorandil for the prevention of contrast‐induced nephropathy: A meta‐analysis of randomized controlled trials

“…The remaining 8 RCTs underwent full‐text review and 4 were further excluded because three of them were repeated abstracts of already included RCTs, and the other one was not with the treatment arm of nicorandil. Finally, four RCTs were included.…”

“…Overall, four RCTs including 709 patients with renal dysfunction or at risk for CIN, who were scheduled for coronary angiography (CAG) or percutaneous coronary intervention (PCI), were included . All of the RCTs were performed in Asian countries.…”

“…Indeed, early animal studies showed that K‐ATP channel openers, including nicorandil, may ameliorate renal injury related to oxidative stress or ischemia‐reperfusion injury . However, subsequent randomized controlled trials (RCTs) which evaluated the potential preventative efficacy of nicorandil against CIN showed inconsistent results . Therefore, in this study, we aimed to perform a meta‐analysis of RCTs to systematically evaluate the efficacy of periprocedural treatment of nicorandil on the incidence of CIN in patients undergoing contrast exposure.…”

Preventive effect of nicorandil on contrast‐induced nephropathy: a meta‐analysis of randomised controlled trials

“…4B). Table 1 Study population and nicorandil administration of included studies Ko et al 5 Nawa et al 10 Fan et al 11 Iranirad et al 12 Study Change in cystatin C Pooled analysis of percentage change in cystatin C from baseline showed that, compared with control, nicorandil was associated with a non-significant trend towards decreased cystatin C (WMD = −2.18%, 95% CI: −4.39 to 0.02) ( Fig. 5A).…”

“…One RCT by Iranirad et al enrolled a relatively higher eGFR patients compared with the other three RCT, 12 and sensitivity analysis excluding this study was conducted. As shown in Table 3, the pooled results were not significantly changed.…”