Efficacy of NHP66 Bioactive Cage on Patients with Cervical Spine Injury in Short-Track Speed Skating

Abstract

Background. Short-track speed skating (STSS) is an extreme sport in pursuit of extreme speed and explosive force. In such a sport, once athletes fall down, they are susceptible to serious cervical spine injury (CSI) under the inertia of high-velocity movement. Nanohydroxyapatite/polyamide 66 (NHP66) bioactive cage is a high-tech product of nanotechnology in the medical field in recent years. With a structure similar to that of human cortical bone, NHP66 bioactive cage has extremely high toughness and strength, which tailors to the needs of STSS. Objective. This study mainly analyzed the therapeutic effect of NHP66 on patients with CSI in STSS, aiming to provide new opportunities for the treatment of this patient population. Methods. A total of 51 patients with CSI treated in our hospital were enrolled, including 19 cases of short-track speed skaters (observation group) and 32 cases of car accidents, falls from heights, or collision injuries (control group). The relevant surgical indicators (operation time, intraoperative blood loss, etc.), the incidence of adverse reactions, the Cobb angle of cervical lordosis before and after surgery, and the fusion segment height of the cage were observed and compared between the two groups. Postoperative pain was evaluated by the visual analog scale (VAS), improvement of spinal cord injury was assessed by the American Spinal Cord Injury Association (ASIA) Impairment Scale, and bone fusion, bone subsidence, and other motor functions were assessed by the Japanese Orthopaedic Association (JOA) score rating system. Results. The operation time, intraoperative blood loss, and incidence of adverse reactions in the observation group were significantly lower than those in the control group. The Cobb angle of cervical lordosis and the fusion segment height of cage increased significantly higher in both groups after surgery. In addition, the VAS scores of the observation group 2 h and 3 d after operation were significantly lower than those of the control group. In terms of improvement of spinal cord injury, ASIA and JOA scores in the observation group were significantly higher than those before treatment and in the control group. There was no significant difference in bone fusion activity between the two groups. Conclusions. In this study, it is found through experiments that NHP66 has higher safety and application value than autogenous iliac bone, confirming that NHP66 can achieve significant results as a cage for anterior cervical decompression and iliac bone graft fusion and internal fixation in short-track speed skaters after CSI.

Selection of Surgical Approach and Clinical Significance of Lower Cervical Spine Injuries Guided by SLIC Scoring System

“…Therefore, when the SLIC score is ≥8, there is a C-type injury classified by AO Spine, and combined anterior-posterior surgery is preferable, and in terms of biomechanical strength of cervical internal fixation, posterior surgery is superior to anterior surgery [14] [15] [16]. In summary, this paper conducted a retrospective study on the correlation between preoperative SLIC score, surgical approach and postoperative efficacy in 75 patients undergoing surgery for cervical spinal cord injury, and scientifically demonstrated the feasibility of SLIC score as a basis for selecting surgical paths.…”

Applied nano-hydroxyapatite/polyamide 66 strut in anterior reconstructive surgery for lumbar spinal tuberculosis： a comparison with autogenous iliac bone graft.

“…Nano-hydroxyapatite (n-HA) is the main inorganic component of bones and teeth and plays a scaffolding role for calcium salt deposition during bone metabolism while inducing new bone formation [24][25] . PA66 is an organic polymer material with a chemical structure similar to that of bone collagen, easy to process, and highly malleable, it has been widely used in biological materials such as surgical sutures [10] . Studies have shown that n-HA is attached to PA66 through hydrogen bonds by the formation of a carboxyl-calcium-carboxyl linkage ([-COO]-Ca2+-[-COO]), which strong interaction between these chemical bonds provides the composite of both the mechanical strength of hydroxyapatite and the elastic properties of polyamide 66 [26] .…”

“…The porous nano-hydroxyapatite/polyamide 66 (n-HA/PA66) bioactive strut is a novel biomedical bionic material whose composition structure and mechanical properties are similar to those of human cortical bone. it has been widely used in spinal reconstruction surgery due to the favorable biomechanical characteristics of the strut [9] [10] .…”

Retracted: Efficacy of NHP66 Bioactive Cage on Patients with Cervical Spine Injury in Short‐Track Speed Skating

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”