Efficacy of new inotropic drugs in clinical coronary heart failure

Jewitt, D. E.; Jennings, K.; Jackson, P G

doi:10.1016/0002-9343(78)90710-6

Cited by 14 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to change myocardial perfusion and hemodynamics, pharmacologic models were chosen. The effects of the substances used are well established in the literature (5,9,13,18).…”

Section: Discussionmentioning

confidence: 99%

“…Under controlled conditions and imaging 3 min post injectionem, the activity over the myocardium averaged 5.3 ± 1.1% of the whole-body 13 N-glutamate activity after absorption correction. 10 min following the onset of the administration of Dipyridamole, an average increase of the relative uptake by 12% was noted.…”

Section: The Effect Of Dipyridamole On Mb F (Fmbf-co)mentioning

confidence: 99%

See 1 more Smart Citation

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects

Wh¹,

Helus²,

Tillmanns³

et al. 1980

Nuklearmedizin

View full text Add to dashboard Cite

Continuous monitoring of cardiac output and sequential studies of right ventricular ejection fraction and of fractional myocardial uptake of substances with high cell affinity can be realized using 13N (t1/2 = 9.6 min) and 81mKr (t1/2 = 13 sec). Thus, it is possible to measure rapid changes of absolute myocardial blood flow and of the inotropic state of the right heart myocardium. This is shown in patients who underwent interventions with Dipyridamole and with Dobutamine which produce a marked increase in myocardial blood flow or cardiac dynamics, respectively.

show abstract

“…In order to change myocardial perfusion and hemodynamics, pharmacologic models were chosen. The effects of the substances used are well established in the literature (5,9,13,18).…”

Section: Discussionmentioning

confidence: 99%

Section: The Effect Of Dipyridamole On Mb F (Fmbf-co)mentioning

confidence: 99%

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects

Wh¹,

Helus²,

Tillmanns³

et al. 1980

Nuklearmedizin

View full text Add to dashboard Cite

show abstract

Myocardial Metabolic Effects of Intravenous Terbutaline in Patients with Severe Heart Failure Due to Coronary Artery Disease

Wang

Lee

et al. 1983

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Intravenous terbutaline, 0.3 mg/kg/min for 30 minutes followed by 0.15 mg/min for 60 minutes, was studied in nine patients with severe heart failure due to documented coronary artery disease. Hemodynamic and myocardial metabolic effects were measured during terbutaline infusion. Cardiac index and stroke index increased, whereas mean pulmonary artery wedge pressure and pulmonary vascular resistance decreased significantly. No significant alterations in aortic oxygen content, coronary sinus oxygen content, myocardial oxygen extraction, and myocardial lactate extraction were observed during terbutaline infusion. No patient developed angina or electrocardiographic changes suggestive of ischemia. These results indicate that intravenous terbutaline infusion, at the dosage employed, produces beneficial hemodynamic effects without a deterioration of myocardial metabolism in patients with heart failure due to coronary artery disease.

show abstract

Inotropic Agents: An Overview

Goldberg

Rajfer

1980

Clinical Pharmacology &Amp; Therapeutics

View full text Add to dashboard Cite

Efficacy of new inotropic drugs in clinical coronary heart failure

Cited by 14 publications

References 19 publications

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects

Short-Lived Radionuclides for the Assessment of Rapid Cardiovascular Drug Effects

Myocardial Metabolic Effects of Intravenous Terbutaline in Patients with Severe Heart Failure Due to Coronary Artery Disease

Inotropic Agents: An Overview

Contact Info

Product

Resources

About