Efficacy of Neem Extract and Three Antimicrobial Agents Incorporated into Tissue Conditioner in Inhibiting the Growth of C. Albicans and S. Mutans

Barua, Dikshita Ray; Basavanna, Jayaprakash Mugur; Varghese, Rana K

doi:10.7860/jcdr/2017/23784.9950

Cited by 17 publications

(22 citation statements)

References 14 publications

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“…[ 21 ] However, it has been reported that antifungal drugs have some toxic effects on the patient if it is overused; hence, the plant extracts neem ( A. indica ) and garlic ( A. sativum ) which are naturally available and also possess antifungal property can be used for the same. [ 4 14 22 23 24 25 26 27 ] This leads to the microbiological investigation conducted in this study, which confirms that the released concentrations of the antifungal agents (plant extracts) from the soft lining materials were able to induce an antifungal effect against C. albicans on agar culture. Furthermore, the changes in any hardness of the denture base after the incorporation of the plant extracts were analyzed.…”

Section: Discussionsupporting

confidence: 71%

“…[ 9 ] Neem ( Azadirachta indica ) is found to have antifungal effect and antimicrobial effect. [ 10 11 12 ] Garlic is another indigenous to Asian region and utilized as a topping, particularly in a large portion of the Asian cooking[ 13 ] since it acts as an antioxidant[ 14 ] (antimicrobial, antibacterial, antiviral, antifungal, and antiprotozoal properties) and also have beneficial properties on the cardiovascular and immune systems. [ 15 16 ] However, only few or no studies have been reported on the use of neem and garlic as an adjunct for the use of treating denture-induced stomatitis.…”

Section: Introductionmentioning

confidence: 99%

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Antifungal efficacy and the mechanical properties of soft liners against Candida albicans after the incorporation of garlic and neem: An In vitro study

Seenivasan

Kumar

Natarajan

et al. 2018

J Int Soc Prevent Communit Dent

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Objectives:To evaluate the in vitro growth inhibition of Candida albicans, in the soft-liner material and Shore A hardness from resin-based denture soft lining materials modified by neem or garlic incorporation.Materials and Methods:Resin discs were prepared with poly methyl methacrylate (PMMA) and soft liners incorporated with varying concentrations of neem or garlic. For antifungal activity, resin discs were placed on agar plates inoculated with C. albicans and were evaluated after 2, 4, and 7 days using the streaking method. The hardness of the PMMA was evaluated with the use of Shore A at 2, 4, and 7 days. Data were statistically processed by SPSS software (IBM Company, Chicago, USA) using Kruskal–Wallis test, and post hoc comparisons were done using Dunn's test. P <0.05 was considered statistically significant.Results:Neem and garlic added to PMMA soft liner had an inhibitory effect on C. albicans. Both the neem and garlic when added showed positive results against C. albicans when compared to the control group. The soft liner hardness increased statistically by time but not for the different plant extract concentrations.Conclusions:Within the limitations of this in vitro study, it was found that neem and garlic can be used as an additive to tissue conditioner to reduce the adherence of C. albicans without significantly affecting the hardness of the heat-polymerized acrylic resin.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Antifungal efficacy and the mechanical properties of soft liners against Candida albicans after the incorporation of garlic and neem: An In vitro study

Seenivasan

Kumar

Natarajan

et al. 2018

J Int Soc Prevent Communit Dent

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“…The findings in this study also matched those observed in the study by Pai et al (2010) where an aqueous extract of A. muricata was reported to be highly effective against Candida species; it is also noteworthy that both aqueous and CSL extracts of A. muricata showed better activity against C. kefyr (Strain A) than all the conventional antibiotics. The minimal antifungal activity of A. indica extracts observed in this study mirrors those reported by Mahmoud et al (2011) where little activity was found against C. albicans, though, in another study, tissue conditional mixed with A. indica extracts at two concentrations was reported to exhibit considerable potential effectiveness against C. albicans (Barua et al, 2017). The MIC values revealed that the aqueous and CSL leave extracts of the F. exasperata inhibited the growth of four of the tested pathogens within range of 6.25-12.5 mg/mL.…”

Section: Discussionsupporting

confidence: 83%

Antifungal activity of aqueous and corn steep liquor extract of Ficus exasperata, Anonna muricata and Azadiractha indica

et al. 2020

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This study investigated the activity of aqueous and corn steep liquor (CSL) extracts of Ficus exaperasta, Annona muricata and Azadirachta indica against Candida spp. isolated from high vaginal swab samples. Phytochemical screening of the plants was done using standard methods, the antifungal activity of the plant's extracts and standard drugs were tested against isolates of Candida spp. using the agar well diffusion method; the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were also determined using microdilution standardized techniques. Phytochemical screening of the aqueous and CSL extracts of the plants revealed the presence of tannin, saponin, flavonoids, and terpenoids. Among the five Candida strain isolates, the zone of inhibition produced by the plant extracts against C. albicans shows a range of 0-18.3 mm; C. krusei (strain A): 5.1-24.5 mm; C. krusei (strain B): 0-18.0 mm; C. kefyr (strain A): 6.1-27.5 mm; and C. kefyr (strain B): 0-22.0 mm. The CSL extract had higher inhibitory action compared with aqueous extract, also F. exasperata and A. muricata gave better antifungal activity against the tested Candida strains. The MIC of the aqueous and CSL extracts of the F. exasperata ranged between 6.25-12.50 mg/mL; A. muricata: 3.125-12.500 mg/mL, while the aqueous and CSL extracts of A. indica was found to have no activity at all the tested concentrations against C. albicans, C. krusei (strain A) and C. krusei (strain B), similar observation for the MFC. This study proved the antifungal efficacy of aqueous and CSL extracts of F. exasperata, A. muricata, and A. indica against isolates of Candida species which are usually implicated in candidiasis.

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“…Due to regular ingestion and persistent salivary washout, the antifungal drugs are less likely to adhere with the oral mucosa [39]. To overcome these issues, a lot of of research has investigated the efficacy of TCs modified by the addition of various antifungal medicaments, such as nystatin [29,38,[40][41][42][43][44][45][46][47], derivatives of the azole group [38,[43][44][45][46][47], and chlorhexidine [45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Role of Nystatin Added to Tissue Conditioners for Treating Denture-Induced Stomatitis: A Systematic Review

et al. 2021

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Denture-induced stomatitis (DIS) represents a pathological condition caused by ill-fitting dentures trauma, manifested as inflammation of the palatal tissue beneath the denture. The fungal infections are the principal contributory factors to DIS. Although the aetiology of DIS is multifactorial, the Candida albicans fungal infection remains the main cause. The objective of the present systematic review was to evaluate the latest literature on the addition of nystatin into the tissue conditioners (TCs) in the management of DIS. To search the published literature about “the addition of nystatin in TCs for treating DIS”, electronic databases (PubMed (National library of medicine) and Cochrane Library (Wiley)) were searched (from 1975 until December 2020) using different keywords. Various studies described the effectiveness and efficacy of incorporating nystatin into several TCs. The present systematic review reported that the addition of nystatin is beneficial, with slight or no consequences on both the mechanical and physical features of TCs. Adding nystatin to various TCs for treating DIS can be suggested.

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Efficacy of Neem Extract and Three Antimicrobial Agents Incorporated into Tissue Conditioner in Inhibiting the Growth of C. Albicans and S. Mutans

Cited by 17 publications

References 14 publications

Antifungal efficacy and the mechanical properties of soft liners against Candida albicans after the incorporation of garlic and neem: An In vitro study

Antifungal efficacy and the mechanical properties of soft liners against Candida albicans after the incorporation of garlic and neem: An In vitro study

Antifungal activity of aqueous and corn steep liquor extract of Ficus exasperata, Anonna muricata and Azadiractha indica

Therapeutic Role of Nystatin Added to Tissue Conditioners for Treating Denture-Induced Stomatitis: A Systematic Review

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