Efficacy of Near-Infrared Fluorescence Video-Assisted Thoracoscopic Surgery for Small Pulmonary Nodule Resection with Indocyanine Green Inhalation: A Randomized Clinical Trial

Wang, Kun; Huang, Weiyuan; Chen, Xianshan; Gao, Li; Li, Na; Huang, Xinxin; Liao, Xuqiang; Song, Jinsheng; Yang, Qianyu; He, Kunshan; An, Yu; Feng, Xiaoshan; Zhang, Zeyu; Chi, Chongwei; Tian, Jie; Chen, Fengxia; Chen, Feng

doi:10.1245/s10434-023-13753-4

Cited by 4 publications

(1 citation statement)

References 47 publications

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“…Minimally invasive thoracic surgery encompasses video-assisted thoracoscopic surgery (VATS) and robot-assisted thoracoscopic surgery (RATS). These approaches offer advantages over open thoracotomy, including reduced pain, decreased incidence of postoperative complications, expedited discharge, and improved tolerance among elderly patients ( 5 , 6 ). Over the past decade, minimally invasive thoracic surgery has developed from utilizing three or four ports to a single incision, which is known as uniportal video-assisted thoracoscopic surgery (U-VATS) ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Uniportal robot-assisted thoracoscopic double-sleeve lobectomy after neoadjuvant immunotherapy

Fang,

Li,

Bosinceanu

et al. 2024

Front. Surg.

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Minimally invasive thoracic surgery, including video-assisted thoracoscopic surgery and robot-assisted thoracoscopic surgery, has been proven to have an advantage over open thoracotomy with less pain, fewer postoperative complications, faster discharge, and better tolerance among elderly patients. We introduce a uniportal robot-assisted thoracoscopic double-sleeve lobectomy performed on a patient following neoadjuvant immunotherapy. Specialized instruments like customized trocars with a reduced diameter, bulldog clamps, and double-needle sutures were utilized to facilitate the maneuverability through the single incision. This technique integrates the merits of multiport robot-assisted thoracic surgery with uniportal video-assisted thoracoscopic surgery.

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Section: Introductionmentioning

confidence: 99%

Case Report: Uniportal robot-assisted thoracoscopic double-sleeve lobectomy after neoadjuvant immunotherapy

Fang,

Li,

Bosinceanu

et al. 2024

Front. Surg.

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Application of indocyanine green in thoracic surgery: A review article

Zhu,

Zhou,

Chen

et al. 2024

Asian Journal of Surgery

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Novel locally nebulized indocyanine green for simultaneous identification of tumor margin and intersegmental plane

Jeon,

Kim,

Kim

et al. 2024

International Journal of Surgery

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Background: Segmentectomy, recommended for early-stage lung cancer or compromised lung function, demands precise tumor detection and intersegmental plane identification. While Indocyanine green (ICG) commonly aids in these aspects using near-infrared (NIR) imaging, its separate administrations through different routes and times can lead to complications and patient anxiety. This study aims to develop a lung-specific delivery method by nebulizing low-dose ICG to targeted lung segments, allowing simultaneous detection of lung tumors and intersegmental planes across diverse animal models. Methods: To optimizing the dose of ICG for lung tumor and interlobar fissure detection, different doses of ICG (0.25, 0.1 and 0.05 mg/kg) were nebulized to rabbit lung tumor models. The distribution of locally nebulized ICG in targeted segments was studied to evaluate the feasibility of detecting lung tumor and intersegmental planes in canine lung pseudotumor models. Results: NIR fluorescence imaging demonstrated clear visualization of lung tumor margin and interlobar fissure using local nebulization of 0.1 mg/kg ICG for only 4 min during surgery in the rabbit models. In the canine model, the local nebulization of 0.05 mg/kg of ICG into the target segment enabled clear visualization of pseudotumor and intersegmental planes for 30 min. Conclusions: This innovative approach achieves a reduction in ICG dose and prolonged the visualization time of the intersegmental plane and effectively eliminates the need for the hurried marking of tumors and intersegmental planes. We anticipate that lung specific delivery of ICG will prove valuable for image-guided limited resection of lung tumors in clinical practice.

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Efficacy of Near-Infrared Fluorescence Video-Assisted Thoracoscopic Surgery for Small Pulmonary Nodule Resection with Indocyanine Green Inhalation: A Randomized Clinical Trial

Cited by 4 publications

References 47 publications

Case Report: Uniportal robot-assisted thoracoscopic double-sleeve lobectomy after neoadjuvant immunotherapy

Case Report: Uniportal robot-assisted thoracoscopic double-sleeve lobectomy after neoadjuvant immunotherapy

Application of indocyanine green in thoracic surgery: A review article

Novel locally nebulized indocyanine green for simultaneous identification of tumor margin and intersegmental plane

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