Efficacy of Natural and Allopathic  Antimicrobial Agents Incorporated onto  Guided Tissue Regeneration Membrane  Against Periodontal Pathogens: An in  Vitro Study

Mehrotra, Neha; Palle, Ajay Reddy; Gedela, Rajani Kumar; Vasudevan, Sanjay

doi:10.7860/jcdr/2017/23851.9227

Cited by 3 publications

(8 citation statements)

References 28 publications

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“…Among all the polymeric biomaterials, the natural collagen membrane is the most widely used as an antibacterial carrier in bone regeneration [ 5 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Several factors may explain this finding: (1) among the degradable membranes, collagen-based ones are the most commonly employed in dentistry because of their bioactivity, biocompatibility, and mechanical properties [ 3 , 7 , 22 ]; (2) they have been found to have many options for loading [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…In these cases, they are less porous and do not have a fibrous micro or nanostructure resembling collagen. These membranes were loaded by incorporation of the antibacterial in the polymer blend solution [ 10 , 12 , 13 , 32 , 39 , 49 , 51 , 55 ] or by immersion or solvent evaporation techniques after membrane production [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 43 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…The second most frequently employed antibiotics are metronidazole [ 5 , 10 , 15 , 20 , 21 , 25 , 33 , 38 , 42 , 52 , 55 , 58 ] and other nitroimidazoles such as ornidazole [ 31 ], niridazole, and tinidazole [ 21 ]. These are antibiotics with antibacterial activity for Gram-negative and anaerobic bacteria [ 25 ], and they are specific against most of the subgingival [ 10 ] and periodontopathic biofilms [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…Other encountered, but less used antibiotics for loading membranes were amoxycillin [ 15 , 16 , 19 ], vancomycin [ 41 ] or azithromycin [ 29 ]. Amoxycillin and vancomycin are antibiotics targeting the bacterial cell wall [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

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Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review

et al. 2022

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Polymeric membranes are frequently used for bone regeneration in oral and periodontal surgery. Polymers provide adequate mechanical properties (i.e., Young’s modulus) to support oral function and also pose some porosity with interconnectivity to permit for cell proliferation and migration. Bacterial contamination of the membrane is an event that may lead to infection at the bone site, hindering the clinical outcomes of the regeneration procedure. Therefore, polymeric membranes have been proposed as carriers for local antibiotic therapy. A literature search was performed for papers, including peer-reviewed publications. Among the different membranes, collagen is the most employed biomaterial. Collagen membranes and expanded polytetrafluoroethylene loaded with tetracyclines, and polycaprolactone with metronidazole are the combinations that have been assayed the most. Antibiotic liberation is produced in two phases. A first burst release is sometimes followed by a sustained liberation lasting from 7 to 28 days. All tested combinations of membranes and antibiotics provoke an antibacterial effect, but most of the time, they were measured against single bacteria cultures and usually non-specific pathogenic bacteria were employed, limiting the clinical relevance of the attained results. The majority of the studies on animal models state a beneficial effect of these antibiotic functionalized membranes, but human clinical assays are scarce and controversial.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review

et al. 2022

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“…A major source of chlorogenic acid can be found in green coffee extract, which is highly bioavailable to humans [41]. A study testing whether treatment outcomes for periodontal regeneration are influenced by loading green coffee extract onto Guided Tissue Regeneration (GTR) membranes indicated that green coffee extract showed no zone of inhibition against P. gingivalis [42]. The authors primarily indicated that GTR membranes loaded with green coffee extract had no preventive effect against P. gingivalis colonization.…”

Section: Discussionmentioning

confidence: 99%

Potential Oral Health Care Agent from Coffee against Virulence Factor of Periodontitis

Tsou

Yang

et al. 2019

Nutrients

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Background: Coffee is a major dietary source of polyphenols. Previous research found that coffee had a protective effect on periodontal disease. In this study, we aimed to investigate whether coffee extract and its primary phenolic acid, chlorogenic acid, affect the growth and protease activity of a periodontopathogen Porphyromonas gingivalis (P. gingivalis). Methods: Coffee extract and chlorogenic acid were prepared by a two-fold serial dilution. The turbid metric test and plate count method were used to examine the inhibitory effects of chlorogenic acid on P. gingivalis. The time-kill assay was used to measure changes in the viability of P. gingivalis after exposure to chlorogenic acid for 0–24 h. The protease activity of P. gingivalis was analyzed using the optical density of a chromogenic substrate. Results: As a result, the minimum inhibitory concentration (MIC) of chlorogenic acid was 4 mg/mL, and the minimum bactericidal concentration was 16 mg/mL. Chlorogenic acid at concentrations above MIC resulted in a longer-lasting inhibitory effect on P. gingivalis viability and significantly reduced associated protease activity. The coffee extract showed antibacterial activity as observed by the disk diffusion test, whereas these inhibitory effects were not affected by different roast degrees of coffee. Conclusions: Collectively, our novel findings indicate that chlorogenic acid not only has antimicrobial activity but also reduced the protease activity of P. gingivalis. In addition, coffee extract inhibits the proliferation of P. gingivalis, which may partly be attributed to the effect of chlorogenic acid.

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Ocimum Sanctum: A Herbal Agent for Revivification of Periodontal Health

Agarwal

Warikoo

Prakash

et al. 2023

PCI- Approved-IJPSN

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The increasing awareness of keeping oral hygiene intact and turning minds into natural therapeutic agents has become a point of concern. India, the diversified homeland to sanative herbs which can supplant harmful and delayed consequence-causing chemical substances, is a boon to the nation. Among all the phytotherapeutic essentials, lies a herb known for being all in one, pharmacological miracle - Ocimum sanctum (or commonly referred to as Tulsi). Tulsi has been applied in various arenas of medicine, especially oral medicine. The plant has immense healing potential. The chemicals extracted from the plant parts of Tulsi are emersed with analgesic, anti-inflammatory, anti-bacterial and anti-ulcerative. These properties are of significant therapeutic importance and are essential for the maintenance of oral hygiene. Apart from its favourable properties, the therapeutic agent is readily available and easy to use. Tulsi can be offered as mouthwashes, gels, irrigating agent, regenerative procedures and nanoparticles. With no harmful effects of producing stains, microbial resistance and similar efficacy to chemical agents, it can be used as an adjunctive treatment. It has shown promising outcomes in preventing tooth decay, pain, gingivitis, halitosis and periodontitis. Building up a new horizon and centre of research, Tulsi and its extravagant benefits are yet to be explored further.

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Efficacy of Natural and Allopathic Antimicrobial Agents Incorporated onto Guided Tissue Regeneration Membrane Against Periodontal Pathogens: An in Vitro Study

Cited by 3 publications

References 28 publications

Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review

Antibiotic-Loaded Polymeric Barrier Membranes for Guided Bone/Tissue Regeneration: A Mini-Review

Potential Oral Health Care Agent from Coffee against Virulence Factor of Periodontitis

Ocimum Sanctum: A Herbal Agent for Revivification of Periodontal Health

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