Efficacy of nasal intermittent positive pressure ventilation in treating apnea of prematurity

Lin, Chyi-Her; Wang, Shan‐Tair; Lin, Yuh-Jyh; Yeh, T. F.

doi:10.1002/(sici)1099-0496(199811)26:5<349::aid-ppul8>3.0.co;2-7

Cited by 115 publications

(88 citation statements)

References 27 publications

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“…These impulses were not noted when the premature infant received nCPAP. 7 There is evidence that these impulses are induced by nIPPV, and could be responsible for recruiting more alveoli and reversing areas of pulmonary microatelectasis, which explains its success. 17 The main factor related to extubation failure, regardless of the study group, was sleep apnea, present in 41.2% of the premature infants.…”

Section: Discussionmentioning

confidence: 99%

“…9 During the study period, whether in the nIPPV or nCPAP method, the occurrence of side effects was not observed, similar to that noted by other authors. 1,6,7,11,19 Barrington et al and Davis et al were unanimous in affirming that nIPPV is a useful and effective method to increase the benefits of nCPAP in the prevention of extubation failure of premature infants in the first hours after extubation. 1, 8 Likewise, Khalaf et al consider nIPPV as more effective than nCPAP in the weaning of premature infants with respiratory distress syndrome (RDS) using mechanical ventilation, and recommend that nIPPV should be used as the primary extubation method even in premature infants with impaired pulmonary function.…”

Section: Discussionmentioning

confidence: 99%

“…However, extubation failure constitutes a frequent problem in these patients, mainly because premature infants easily develop hypoventilation and atelectasis, causing episodes of severe apnea. 1,4,7 Extubation failure is concern-ing because in addition to prolonging the ventilatory support time, it also increases the likelihood of airway trauma and nosocomial infection upon re-intubation.…”

Section: Introductionmentioning

confidence: 99%

“…1, 10,11 Although there are few studies on the use of nIPPV, most research consists of a small number of newborns and/or observation for a short period after extubation. 1,7,12 Method Sample Seventy-two newborns were studied, all with a GA ≤ 36 weeks and 6 days and BW > 750 g, and respiratory failure requiring orotracheal intubation and mechanical ventilation at the Unidade de Cuidados Intensivos Neonatal, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (HC-FMUSP) and the Unidade de Terapia Intensiva Neonatal, Hospital Estadual Mário Covas de Santo André (UTIN HESA).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Komatsu

Diniz

Ferraro

et al. 2016

Rev. Assoc. Med. Bras.

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Objective:To analyze the frequency of extubation failure in premature infants using conventional mechanical ventilation (MV) after extubation in groups subjected to nasal intermittent positive pressure ventilation (nIPPV) and continuous positive airway pressure (nCPAP). Method: Seventy-two premature infants with respiratory failure were studied, with a gestational age (GA) ≤ 36 weeks and birth weight (BW) > 750 g, who required tracheal intubation and mechanical ventilation. The study was controlled and randomized in order to ensure that the members of the groups used in the research were chosen at random. Randomization was performed at the time of extubation using sealed envelopes. Extubation failure was defined as the need for re-intubation and mechanical ventilation during the first 72 hours after extubation. Results: Among the 36 premature infants randomized to nIPPV, six (16.6%) presented extubation failure in comparison to 11 (30.5%) of the 36 premature infants randomized to nCPAP. There was no statistical difference between the two study groups regarding BW, GA, classification of the premature infant, and MV time. The main cause of extubation failure was the occurrence of apnea. Gastrointestinal and neurological complications did not occur in the premature infants participating in the study. Conclusion: We found that, despite the extubation failure of the group of premature infants submitted to nIPPV being numerically smaller than in premature infants submitted to nCPAP, there was no statistically significant difference between the two modes of ventilatory support after extubation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Komatsu

Diniz

Ferraro

et al. 2016

Rev. Assoc. Med. Bras.

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show abstract

“…23 Noninvasive ventilation appears to be beneficial in the management of apnea of prematurity, for the prevention of extubation failures, and in the initial management of RDS. [24][25][26] NCPAP has been used as a primary mode for RDS treatment, to prevent extubation failures, or extubation following surfactant administration. NCPAP can be delivered using conventional mechanical ventilators, bubble continuous positive airway pressure (CPAP), or infant flow driver systems.…”

Section: Noninvasive Ventilation Strategiesmentioning

confidence: 99%

Lung protective ventilatory strategies in very low birth weight infants

Ramanathan

Sardesai

2008

J Perinatol

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Respiratory distress syndrome (RDS) is the most common respiratory diagnosis in preterm infants. Surfactant therapy and mechanical ventilation using conventional or high-frequency ventilation have been the standard of care in the management of RDS. Bronchopulmonary dysplasia (BPD) continues to remain as a major morbidity in very low birth weight infants despite these treatments. There is no significant difference in pulmonary outcome when an optimal lung volume strategy is used with conventional or high-frequency ventilation. Lung injury is directly related to the duration of invasive ventilation via the endotracheal tube. Studies using noninvasive ventilation, such as nasal continuous positive airway pressure and noninvasive positive pressure ventilation, have shown to decrease postextubation failures as well as a trend toward reduced risk of BPD. Lung protective ventilatory strategy may involve noninvasive ventilation as a primary therapy or following surfactant administration in very preterm infants with RDS. Initial steps in the management of preterm infants may also include sustained inflation to establish functional residual capacity, followed by noninvasive ventilation to minimize lung injury and subsequent development of BPD.

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Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity

Lemyre

Davis

Paoli

2002

Cochrane Database of Systematic Reviews

130

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Efficacy of nasal intermittent positive pressure ventilation in treating apnea of prematurity

Cited by 115 publications

References 27 publications

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Lung protective ventilatory strategies in very low birth weight infants

Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity

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