Efficacy of N‐terminal pro‐brain natriuretic peptide digit number for screening of cardiac disease in new haemodialysis patients

Iwasaki, Masaki; Joki, Nobuhiko; Tanaka, Yuri; Ikeda, Nobutaka; Hayashi, Takuma; Kubo, S; Asakawa, Takasuke; Takahashi, Yasunori; Hirahata, Koichi; Imamura, Yoshihiko; Hase, Hiroki

doi:10.1111/nep.12063

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…NT‐proBNP is useful to establish a prognosis in heart failure and to identify asymptomatic or symptomatic left ventricular dysfunction, coronary artery disease and myocardial ischemia. In HD patients, NT‐proBNP was proved to be a screener of asymptomatic cardiac disease, a strong predictor of overall mortality in HD patients . Our finding that MLR being positively associated with NT‐proBNP indicated the MLR might be correlated with cardiac function, which was also consistent with our main finding that MLR served as a predictor of CVD deaths in HD patients.…”

Section: Discussionsupporting

confidence: 90%

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Fei

Chen

Cao

et al. 2017

Hemodialysis International

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Section: Discussionsupporting

confidence: 90%

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Fei

Chen

Cao

et al. 2017

Hemodialysis International

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“…In another study, the NT-proBNP level with a digit number of 5 or greater was found to be associated with cardiovascular diseases in ESRD patients. An NT-proBNP level of 10000 pg/mL was determined as the best cutoff level for left ventricular systolic dysfunction whereas a level of 6000 pg/mL was the best cutoff level for the diagnosis of coronary artery disease in ESRD patients (29). In our study, there was a statistically significant relationship between an NT-proBNP level >12914 pg/ml and LVH.…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 52%

“…Malnutrition and inflammation may affect the NT-proBNP level (29). Therefore, interpretation of the NT-proBNP level is even more challenging in the coexistence of overhydration, malnutrition and inflammation in HD patients (30).…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Nementioning

confidence: 99%

Association Between New Cardiac Biomarkers and Cardiovascular Abnormalities in Asymptomatic Hemodialysis Patients

Bardak¹,

Sari²,

Horoz³

et al. 2017

Turk Neph Dial Transpl

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“…Although previous studies showed that serum biomarkers of cardiac hypertrophy, BNP 7, 17) and NT-proBNP 9, 18) , are useful in predicting all-cause mortality and CVD events in dialysis populations, no study examined the relationship between CTR and risk for CVD events in patients with CKD. In this study, we confirmed the previous findings regarding NT-proBNP.…”

Section: Discussionmentioning

confidence: 99%

Cardiothoracic Ratio as a Predictor of Cardiovascular Events in a Cohort of Hemodialysis Patients

Okute

Shoji

Hayashi

et al. 2017

J Atheroscler Thromb

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Aim: The cardiothoracic ratio (CTR) on a chest X-ray is an indicator of cardiac enlargement, although its predictive power for cardiovascular disease (CVD) events in chronic kidney disease is unknown. We examined it in a cohort of hemodialysis patients, as compared with an N-terminal fragment of probrain natriuretic peptide (NT-proBNP).Method: This was an observational study with cross-sectional and longitudinal analyses including 517 maintenance hemodialysis patients and 122 healthy control subjects. The main predictors were CTR and serum NT-proBNP, and the main outcome was CVD events in 5 years.Results: At baseline, the hemodialysis patients had higher median (interquartile range) levels of CTR [0.487 (0.457–0.520)] than the control group [0.458 (0.432–0.497)]. In the hemodialysis group, CTR was positively correlated with NT-proBNP (Spearman's r = 0.44, P < 0.001). During follow-up, 190 CVD events occurred. CTR was significantly associated with the risk of CVD [HR 2.12 (95% CI, 1.38–3.25) for the fourth quartile as compared with the second quartile of CTR] in a multivariate Cox model. In the same model, NT-proBNP (fourth versus first quartile) showed a HR of 3.27 (2.02–5.31). When CTR and NT-proBNP were simultaneously included as predictors, only NT-proBNP remained a significant predictor of CVD events, all-cause mortality and composite of CVD plus all-cause mortality.Conclusions: We showed that CTR was a significant and independent predictor of CVD in hemodialysis patients. CTR can be used for CVD risk stratification in hemodialysis patients when NT-proBNP is not available.

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Efficacy of N‐terminal pro‐brain natriuretic peptide digit number for screening of cardiac disease in new haemodialysis patients

Cited by 6 publications

References 29 publications

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Monocyte/lymphocyte ratio as a better predictor of cardiovascular and all‐cause mortality in hemodialysis patients: A prospective cohort study

Association Between New Cardiac Biomarkers and Cardiovascular Abnormalities in Asymptomatic Hemodialysis Patients

Cardiothoracic Ratio as a Predictor of Cardiovascular Events in a Cohort of Hemodialysis Patients

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