Efficacy of Mung Bean (Lentil) and Pop Rice Based Rehydration Solutions in Comparison with the Standard Glucose Electrolyte Solution

Mk, Bhan; Op, Ghai; Khoshoo,; Vasudev, Anand S.; Bhatnagar, Shinjini; Nk, Arora; Rashmi, Rashmi; Stintzing, G

doi:10.1097/00005176-198705000-00016

Cited by 45 publications

(21 citation statements)

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“…Eighteen trials used varieties of rice (precooked, uncooked and pop rice), three trials evaluated maltodextrins (Akbar 1991; Santos Ocampo 1993; el-Mougi 1996), one trial used amylase-resistant starch (Ramakrishna 2000) and another used plantain flour (Bernal 2005). One trial each had rice-based ORS in one trial arm and at least another polymer group: wheat (Alam 1987; Alam 1987, wheat); mung beans (Bhan 1987; Bhan 1987, mung bean); sorghum (Mustafa 1995, sorghum) ;and wheat, millet, maize, sorghum, and potatoes (Molla 1989b). In trials with more than one polymer group, they were reported separately.…”

Section: Resultsmentioning

confidence: 99%

“…A few trials reported the number of participants with vomiting (11 trials) (Patra 1982; Bhan 1987; el-Mougi 1988; Mohan 1988; Alam 1992; Islam 1994; Mustafa 1995, rice; Mustafa 1995, sorghum; Dutta 1998, adults; Dutta 1998, children; Iyngkaran 1998); hyponatraemia (six trials) (Dutta 1988; Guiraldes 1995a; Bhattacharya 1998; Dutta 2000; Zaman 2001; Ramakrishna 2008); hypokalaemia (two trials) (Bhan 1987; Zaman 2007); and development of persistent diarrhoea (two trials) (Fayad 1993; Faruque 1997). …”

Section: Resultsmentioning

confidence: 99%

“…Of the 35 trials, 24 trials used adequate methods to generate the allocation sequence (computer-generated or random-numbers table) and 11 trials used methods that were unclear (Patra 1982; Bhan 1987; Mohan 1988; Molla 1989a; Mustafa 1995; Razafindrakoto 1993; Faruque 1997; Iyngkaran 1998; Sharma 1998; Nanulescu 1999; Intarakhao 2010). …”

Section: Resultsmentioning

confidence: 99%

“…Only 12 trials used an adequate method to conceal allocation (Patra 1982; Bhan 1987; Fayad 1993; Santos Ocampo 1993; Maulen-Radovan 1994; Guiraldes 1995a; Guiraldes 1995b; el-Mougi 1996; Hossain 2003; Maulen-Radovan 2004; Bernal 2005; Zaman 2007). The method was unclear in the other 23 included trials.…”

Section: Resultsmentioning

confidence: 99%

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Polymer-based oral rehydration solution for treating acute watery diarrhoea

Gregorio

Gonzales

Dans

et al. 2016

Cochrane Database of Systematic Reviews

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BackgroundAcute diarrhoea is one of the main causes of morbidity and mortality among children in low-income countries. Glucose-based oral rehydration solution (ORS) helps replace fluid and prevent further dehydration from acute diarrhoea. Since 2004, the World Health Organization (WHO) has recommended the osmolarity of less than 270 mOsm/L (ORS ≤ 270) versus greater than 310 mOsm/L formulation (ORS ≥ 310). Polymer-based ORS (for example, prepared using rice or wheat) slowly releases glucose and may be superior to glucose-based ORS.ObjectivesTo compare polymer-based oral rehydration solution (polymer-based ORS) with glucose-based oral rehydration solution (glucose-based ORS) for treating acute watery diarrhoea.Search methodsWe searched the following sources up to 5 September 2016: the Cochrane Infectious Diseases Group (CIDG) Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library 2016, Issue 9), MEDLINE (1966 to 5 September 2016), EMBASE (1974 to 5 September 2016), LILACS (1982 to 5 September 2016), and mRCT (2007 to 5 September 2016). We also contacted researchers, organizations, and pharmaceutical companies, and searched reference lists.Selection criteriaWe included randomized controlled trials (RCTs) of people with acute watery diarrhoea (cholera and non-cholera associated) that compared polymer-based and glucose-based ORS (with identical electrolyte contents).Data collection and analysisTwo review authors independently assessed the search results and risk of bias, and extracted data. In multiple-treatment arms with two or more treatment groups, we combined outcomes as appropriate and compared collectively with the control group.Main resultsThirty-five trials that included 4284 participants met the inclusion criteria: 28 trials exclusively included children, five included adults, and two included both adults and children.Polymer-based ORS versus glucose-based ORS (osmolarity ≤ 270)Eight trials (752 participants) evaluated this comparison, and seven trials used rice as a polymer source. Polymer-based ORS may decrease mean stool output in the first 24 hours by 24 mL/kg (mean difference (MD) −24.60 mL/kg, 95% CI −40.69 to −8.51; one trial, 99 participants, low quality evidence). The average duration of diarrhoea may be reduced by eight hours (MD −8.24 hours, 95% CI −13.17 to −3.30; I² statistic = 86%, five trials, 364 participants, low quality evidence) with polymer ORS but results are heterogeneous. Limited trials showed no observed difference in the risk of unscheduled use of intravenous fluid (RR 0.66, 95% CI 0.43 to 1.02; I² statistic = 30%; four trials, 376 participants, very low quality evidence), vomiting (very low quality evidence), and hyponatraemia (very low quality evidence).Polymer-based ORS versus glucose-based ORS (osmolarity ≥ 310)Twenty-seven trials (3532 participants) evaluated this comparison using a variety of polymers. On average, polymer ORS may reduce the total stool output in the first 24 hours by around 65 mL/kg (MD −65.47 mL/kg, 95% CI −83....

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Polymer-based oral rehydration solution for treating acute watery diarrhoea

Gregorio

Gonzales

Dans

et al. 2016

Cochrane Database of Systematic Reviews

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“…The search for an improved solution has lead to studies with aminoacids, rice and other cereals, maltodextrines, hydrolysed proteins, low osmolarity solutions, and short polymers of glucose (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”

Section: -5253mentioning

confidence: 99%

Oral rehydration with a plantain flour‐based solution in children dehydrated by acute diarrhea: a clinical trial

et al. 1997

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A clinical trial was conducted in order to prove the efficacy of a solution containing 50 g/l of plantain flour and 3.5 g/l of sodium chloride (NaCl) for the rehydration of children with acute diarrheal diseases. 121 children were given WHO-ORS (Group A) and 117 a plantain flour-based solution (Group B). Rehydration was successful in 85.9% in Group A and 88.0% in Group B (p = 0.634). Rehydration was completed in 5.28 h (SD 1.99) in Group A and in 4.88 h (SD 2.11) in Group B (p = 0.132). The average solution intake for rehydration was 24.56 ml/kg/h (SD 10.12) in Group A and 21.17 ml/kg/h (SD 9.35) in Group B (p = 0.00782). The mean stool output during rehydration was 8.45 g/kg/h (SD 9.72) in Group A and 4.69 g/kg/h (SD 4.98) in Group B (p = 0.00053). Decrease in blood levels of sodium and potassium occurred in some children in group B. The plantain flour-based solution proved effective for the treatment of dehydration due to acute diarrheal diseases and should be considered as an alternative when standard WHO-ORS is not available.

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