Efficacy of multiple microwave endometrial ablation technique for menorrhagia resulting from adenomyosis

Nakamura, Kazuto; Nakayama, Kentaro; Ishikawa, Masatoshi; Katagiri, Hiroshi; Katagiri, Atsuko; Ishibashi, Tatsuro; Sato, Emi; Asakawa, Yasuyuki; Kyo, Satoru

doi:10.1111/jog.12787

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…In that study, we found that MEA tended to be less effective in this patient population, than in women with myomas ( 2 ). We also found that multiple rounds of MEA treatment may more successfully control menorrhagia from adenomyosis ( 21 ). We postulated that the thickened myometrium in women with adenomyosis caused the resistance to MEA treatment and was associated with recurrence or re-surgery.…”

Section: Discussionmentioning

confidence: 66%

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

et al. 2017

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This study aimed to describe the long-term outcomes of patients with menorrhagia treated with microwave endometrial ablation (frequency, 2.45 GHz), as well as to identify factors associated with recurrence or re-surgery. This retrospective cohort study was conducted from 2007 to 2015 at Shimane University Hospital in Japan. Patients with severe menorrhagia and a desire to preserve their uterus were included in the study. Clinical factors associated with recurrence of menorrhagia or re-surgery were analyzed with a multivariable logistic regression model. Of 160 microwave endometrial ablation candidates, 100 had uterine myomas, 20 adenomyosis, 26 functional excessive menstruation, and 12 endometrial polyps. In the full cohort, age (<40) and uterine cavity length (≥10) were associated with recurrence of menorrhagia and re-surgery. Among patients with myomas, age (<48) and number of myomas (≥4) were associated with recurrence, and largest myoma size (≥5) and preoperative hemoglobin level (<9 mg/dl) were associated with re-surgery. Among subjects with adenomyosis, uterine cavity length (≥10) was associated with recurrence. Microwave endometrial ablation is thought to be a highly efficacious method to control menorrhagia caused by functional bleeding and endometrial polyps. However, microwave endometrial ablation may be less effective for patients younger than 48 years with myomas, especially those with 4 or more myomas, or with a myoma 5 cm or larger in size, and for patients with adenomyosis who have a thickened myometrium. These clinical factors may be useful predictors of success in selecting candidates for microwave endometrial ablation.

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Section: Discussionmentioning

confidence: 66%

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

et al. 2017

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“…D-ribose was subsequently indicated to be clinically beneficial for treating certain diseases, such as congestive heart failure (CHF) (7)(8)(9)(10). Although D-ribose is not stored in cells, it is essential in cell resynthesizing (7,11,12), remedial synthesis and ischemia and hypoxia (13)(14)(15). D-ribose may also be supplemented intravenously, via oral therapy or via other exogenous means, and is utilized in several D-ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)…”

Section: Introductionmentioning

confidence: 99%

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Wang

Xiao

et al. 2021

Exp Ther Med

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The quality of life of patients with certain diseases may be improved through the development of technologies and advancements in pharmacology, with the aim of prolonging their life. However, congestive heart failure (CHF), as well their complications, continue to be the leading cause of disease-associated death. The mechanisms underlying the development and progression of diabetes and CHF have been uncovered in a stepwise manner and the understanding of these mechanisms has improved the management of these diseases, resulting in reduced mortality and morbidity rates; however, CHF remains the leading cause of death worldwide, particularly in developed countries. In the past decades, research has indicated that several supplements and naturally occurring compounds may be used to treat muscle weakness, for cardiac failure management, rehabilitation following myocardial ischemia-reperfusion and various complications of diabetes. D-ribose is an essential component of the respiratory, skeletal and nervous systems and is a popular compound, as its supplementation may have beneficial effects. In the present review, the physiological roles, toxic reactions and the potential use of D-ribose in the management of clinical diseases are summarized. Contents 1. Introduction 2. Physiological roles of D-ribose 3. Clinical applications of D-ribose 4. Potential hazards of high concentrations of D-ribose 5. Conclusions and future perspectives

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“…However, it is unknown whether myomas or adenomyosis can be ablated. We estimated that the microwaves destroy a part of the adenomyosis as well as the basal layer of the endometrium and the glands, since post‐MEA MRIs reveal a shrunken uterus . Once the endometrium shrinks, dienogest can be used to suppress the ectopic endometrium .…”

Section: Discussionmentioning

confidence: 99%

“…We estimated that the microwaves destroy a part of the adenomyosis as well as the basal layer of the endometrium and the glands, since post-MEA MRIs reveal a shrunken uterus. 6 Once the endometrium shrinks, dienogest can be used to suppress the ectopic endometrium. 19 The procedure we follow is to destroy the basal layer of the endometrium, where new endometrium usually develops from, and then prevent formation of new endometrium via dienogest use.…”

Section: Discussionmentioning

confidence: 99%

“…However, it has been noted that MEA is not very effective in treating dysmenorrhea, although uterine adenomyosis is a proven causal factor for both menorrhagia and dysmenorrhea . Recently, several therapeutic medications such as gonadotropin‐releasing hormone agonists (GnRHa), danazol, progestin and estrogen/progestin combinations have been used for treating adenomyosis‐related dysmenorrhea.…”

Section: Introductionmentioning

confidence: 99%

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Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis

Ota

Takahashi

Shiraishi

et al. 2018

J of Obstet and Gynaecol

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Efficacy of multiple microwave endometrial ablation technique for menorrhagia resulting from adenomyosis

Abstract: Multiple MEA successfully controls menorrhagia from adenomyosis and achieves a higher satisfaction rate than single MEA.

Cited by 11 publications

References 8 publications

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

D‑ribose: Potential clinical applications in congestive heart failure and diabetes, and its complications (Review)

Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis

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