Efficacy of Monacrosporium thaumasium in the control of goat gastrointestinal helminthiasis in a semi-arid region of Brazil

Vilela, Vinícius Longo Ribeiro; Feitosa, Thaís Ferreira; Braga, Fábio Ribeiro; Araújo, Jackson Víctor de; Lucena, Samuel Cavalcante de; Dantas, Elaine Silva; Athayde, Ana Célia Rodrigues; Silva, Wilson Wouflan

doi:10.1007/s00436-012-3078-4

Cited by 21 publications

(13 citation statements)

References 20 publications

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“…synthe c chemical eggs (Taylor et al 2013) Flavopiridol synthe c chemical protein kinases (Taylor et al 2013) Invermec n synthe c chemical eggs (Taylor et al 2013) Monacrosporium salinum secondary metabolites larvicidal (Liu et al 2015) Monacrosporium thaumasium secondary metabolites larvicidal (Vilela et al 2013) Bacillus thuringiensis Cry14A growth and development (Wei et al 2003) Perspec ves using a variety of solvents (e.g., ethanol, acetone, chloroform, methanol, water). Each solvent will cause plant cells to release different categories of metabolites based on polarity and hydrophilicity.…”

Section: Perspec Vesmentioning

confidence: 99%

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

French

2018

EBL

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Anthelmintic resistance in livestock is increasing globally. Livestock intestinal parasites now develop resistance to synthetic anthelmintics within 2–10 years, collectively costing billions of dollars annually in lost revenue around the world. Over-reliance on commercial drugs and dips and changes in livestock management practices are key drivers of this trend. To date, current research has focused on identifying new anthelmintics from bacterial and fungal sources or even synthesizing new drugs that target parasite metabolism or reproduction. Plant-derived anthelmintics are a promising alternative, yet to date major research funders and scientists have overlooked this option. Until the mid-20th century, rural communities relied on plant-based methods of controlling livestock parasites. These methods include feeding livestock specific medicinal plants and trees, grazing livestock on herbal leys, and changing where livestock grazed based on ecological factors (e.g., flooding) that increased parasite burdens. Many historic texts and ethnological accounts record the ethnobotanical knowledge of rural communities and the plants they used to control livestock intestinal parasites. Some traditions persist today yet the farmers, graziers, and shepherds who hold this knowledge are rapidly disappearing and with them perhaps a potential long-term solution to anthelmintic resistance. This short perspective piece will cover recent research using ethnobotanical data as a means to identifying potential new anthelmintics; the morphological, physiological, and metabolic effect of plant secondary metabolites on parasites; and an overview of “best practices” which can reduce bias in assessments of plant bioactivity and increase reproducibility of test results. This will hopefully bring recent advances in ethnobiology, chemistry, and ecology to new audiences, and, potentially, spark new interest in using medicinal plants to improve livestock health.

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Section: Perspec Vesmentioning

confidence: 99%

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

French

2018

EBL

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“…Studies have focused on evaluating the efficacy of various species of fungus in different animal species, with different doses and in different environments BRAGA et al, 2009;TAVELA et al, 2013;VILELA et al, 2013VILELA et al, , 2016. Studies evaluating the effectiveness of nematophagous fungi in integrated nematodiasis control systems in association with use of chemical compounds are scarce.…”

Section: Introductionmentioning

confidence: 99%

Control of sheep gastrointestinal nematodes using the combination of Duddingtonia flagrans and Levamisole Hydrochloride 5%

Vilela

Feitosa

Braga

et al. 2018

Rev. Bras. Parasitol. Vet.

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The objective was to evaluate the action of D. flagrans pellets in association with Levamisole Hydrochloride 5% for controlling sheep gastrointestinal nematodes in the northeastern Brazil. Three groups of six sheep each were formed: group 1 received 3 g of the pellets (0.6 g of D. flagrans mycelium) for each 10 kg b.w., twice a week for six months, and deworming with Levamisole Hydrochloride 5% when EPG ≥ 1500; group 2 received a dosage of Levamisole Hydrochloride 5% when EPG ≥ 1500; and group 3 received 3 g of pellets without fungi for each 10 kg b.w., twice a week for six months. EPG counts, larval cultures, packed cell volume (PCV) and weighing were performed every 15 days; monthly, samples of grass from each paddock were collected. The mean EPG of the groups began to statistically differ from day 30 (p < 0.05). Group 1 required less deworming with Levamisole Hydrochloride 5% and showed superiority of PCV values throughout the experiment (p < 0.05). There was a significant reduction (p < 0.05) in L3 recovery in the group 1 paddock from day 30 onwards. The use of D. flagrans pellets in association with Levamisole Hydrochloride 5% was effective for controlling gastrointestinal nematodes.

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“…For the in vivo experiment of fungal isolates in sheep and the excretion time experiment of SDH035 isolate in feces of sheep after oral administration, according to Waghorn et al [24], the geometric mean of L3 in each group was calculated, and the efficacy (i.e., reduction in the number of larvae) of the fungal treatment was determined as follows: 3.2 | The excretion time of D. flagrans SDH035 isolate in the feces of sheep after administration and efficacy of reduction for L3…”

Section: Discussionmentioning

confidence: 99%

“…One isolate of A. cookedickinson (BS002) presented a moderate percentage reduction (71.80%) for T. colubriformis and 77.60% reduction for H. contortus . These differences may be related to the type of fungi, the geographical environment, the climate, and the types of samples used . A substantial research work has focused on D. flagrans as a biocontrol tool for parasitic nematodes in animals.…”

Section: Discussionmentioning

confidence: 99%

“…For the in vivo experiment of fungal isolates in sheep and the excretion time experiment of SDH035 isolate in feces of sheep after oral administration, according to Waghorn et al , the geometric mean of L3 in each group was calculated, and the efficacy (i.e., reduction in the number of larvae) of the fungal treatment was determined as follows:

% E f f i c a c y = 1 - true[\frac{normalg normalr normalo normalu normalp normalm normale normala normaln normalL 3 normals normala normalt normalt 2}{true(normalg normalr normalo normalu normalp normalm normale normala normaln normalL 3 normals normala normalt normalt 1 normala normaln normald normalt 3 true) / 2} true] \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

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In vitro and in vivo studies of the native isolates of nematophagous fungi from China against the larvae of trichostrongylides

Wang

et al. 2016

J Basic Microbiol

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To screen potential nematophagous fungi candidates for the biological control of parasitic nematodes in livestock, in vitro and in vivo studies of the native isolates of nematophagous fungi against the larvae of trichostrongylides were conducted. The in vitro predatory activity of 16 native nematophagous fungal isolates on the larvae of trichostrongylides in sheep feces was assessed. In the ten isolates of Duddingtonia flagrans, the reduction percentage for the infective larvae (L3) of Trichostrongylus colubriformis ranged from 57.21 to 99.83%, and that of Haemonchus contortus ranged from 62.12 to 99.88%. The analysis of the same assay on five isolates of Arthrobotrys superba and one isolate of A. cookedickinson (Monacrosporium cystosporum) showed comparable results with those for D. flagrans. To determine the excretion time of fungal isolates in feces after oral administration, D. flagrans (SDH035) were studied in vivo in sheep and rabbits. Results showed that the tested fungal isolates existed in sheep feces from 12 to 72 h after fungal treatment, and the fungal excretion in rabbit feces occurred at 4 h, reached a peak at 10 h, and declined gradually 18 h after oral administration. All the native fungal isolates were assessed after passing through the gastrointestinal tract of sheep. Treatment with isolates of D. flagrans significantly reduced the number of developing larvae in the feces, and the efficacies ranged from 55.15 to 98.82%. One out of the five isolates of A. superba and A. cookedickinson (BS002) survived after passing through the gastrointestinal tract, and the L3 reduction rates were 83.79 and 81.33%, respectively. Results of the present study provide information about the in vitro predatory activity of nematophagous fungi from China on the L3 of trichostrongylides and their ability to pass through the gastrointestinal tract before administering them for biocontrol.

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Efficacy of Monacrosporium thaumasium in the control of goat gastrointestinal helminthiasis in a semi-arid region of Brazil

Cited by 21 publications

References 20 publications

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

Plant-Based Solutions to Global Livestock Anthelmintic Resistance

Control of sheep gastrointestinal nematodes using the combination of Duddingtonia flagrans and Levamisole Hydrochloride 5%

In vitro and in vivo studies of the native isolates of nematophagous fungi from China against the larvae of trichostrongylides

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