Efficacy of Mohs Micrographic Surgery for the Treatment of Dermatofibrosarcoma Protuberans

Foroozan, Majid; Séi, J.-F.; Amini, Mona; Beauchet, Alain; Saïag, Philippe

doi:10.1001/archdermatol.2012.1440

Cited by 121 publications

(102 citation statements)

References 45 publications

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“…The only difference is presence of melanin containing dendritic cells in the Bednar tumor. These dendritic cells show positive immunostaining for HMB-45 and S100 (8,9,12). Our case was immunohistochemically negative for S100.…”

Section: Discussionmentioning

confidence: 53%

“…Dermatofibroma is a tumor of the dermis, whereas DFSP frequently infiltrates the subcutaneous adipose tissue. Our case was distinguished from dermatofibroma with its prominent storiform pattern, increased mitotic activity (2-3/10 HPF) and diffuse positive immunohistochemical staining for CD34 (8,9,12). CD34, which is a myeloid progenitor cell antigen, is an important marker for the diagnosis of DFSP.…”

Section: Discussionmentioning

confidence: 72%

“…Its presence has also been described in many fibroblast like cells. For these reasons, CD34 is an important antigen in the differential diagnosis of DFSP (6,8,9,12,13).…”

Section: Discussionmentioning

confidence: 99%

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A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

Ozcan¹,

Hacıhasanoğlu²,

Nazli³

et al. 2016

J Breasth Health

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Dermatofibrosarcoma protuberans is a slow-growing, local aggressive fibrous tumor of the subcutaneous tissue, frequently seen in the proximal extremities and the trunk. Its occurrence in the breast is very rare. Herein, we present a female who presented with a breast mass, and aim to discuss pathological features and differential diagnosis of dermatofibrosarcoma protuberans. A 44-year-old female presented to our clinic with a mass on her breast. Physical examination revealed a 8x5.5 cm mass with multilobular nodules on the skin in the lower inner quadrant of her right breast. Her mammography revealed a hyperdense, 7.5x6.5 cm, well-demarcated, lobulated mass in the right breast, which caused nodules on the lower paraareolar portion of the breast skin. There was no axillary lymphadenopathy on both clinical and radiologic examinations. A core needle biopsy had been performed prior to her referral to our center, which revealed a 'spindle cell lesion'. The patient underwent simple mastectomy. On macroscopic examination; the skin over the lesion appeared ulcerated, and there was a well-defined solid mass, which was pale white-tan on the cut surface. Microscopic examination revealed monotonous spindle cell proliferation arranged in storiform pattern within the collagenous stroma with irregular extensions into deep adipose tissue. There were no necrosis or nuclear pleomorphism. The mitotic rate was 2-3/10 HPF. Immunohistochemically tumor cells showed diffuse CD34 positivity, and S100, EMA and SMA negativity. Based on histopathological and immunohistochemical findings, the lesion was diagnosed as dermatofibrosarcoma protuberans. Local recurrence is expected in 20-50% of these cases. Its treatment requires complete surgical excision with wide margins. Distant metastases, although rare, have been reported.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 72%

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A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

Ozcan¹,

Hacıhasanoğlu²,

Nazli³

et al. 2016

J Breasth Health

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show abstract

“…However, MMS requires considerable training, a specialized team, and multiple stages of surgery. Last study by Foroozan et al (2012) found out a mean raw recurrence rate of 1.03% after Mohs micrographic surgery among 19 nonrandomized non comparative trials. Mehrany K et al (2006) argued that chemotherapy is not useful in the treatment of localized DFSP.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Dermatofibrosarcoma Protuberans

Zakaria¹,

Guan²,

Thangaratnam³

et al. 2012

IJCRM

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Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous neoplasm with a high frequency of recurrence after inadequate primary treatment. It is most commonly seen in individuals in their third to fifth decades but has been reported in all age groups. Literatures regarding Dermatofibrosarcoma protuberans accounts for less than 0.1% of all malignant neoplasms and approximately 1% of all soft tissue sarcomas. The incidence has been estimated to be 0.8 to 5 cases per 1 million people per year. A wide-margin surgical excision with microscopically disease-free margins is the standard treatment. We report two cases of dermatofibrosarcoma protuberans at different sites of the body and present a detailed discussion of the diagnosis, treatment and outcomes with reference to available literatures.

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“…Here are the reasons why we think that there is low possibility of lung cancer secondary to DFSP for this patient. First, the probability of regional or distant metastasis is less than 4% of all cases, although it is more common after recurrence and with high-grade lesions (21,22). Next the lung metastases often distributes in the peripheral and subpleural lung regions.…”

Section: A B Cmentioning

confidence: 99%

Differential diagnosis of acute miliary pulmonary tuberculosis from widespread-metastatic cancer for postoperative lung cancer patients: two cases

et al. 2017

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Pulmonary infections and lung cancer can resemble each other on radiographic images, which makes it difficult to diagnosis accurately and apply an appropriate therapy. Here we report two cases that two postoperative patients with lung adenocarcinoma developed diffuse nodules in bilateral lungs in a month which needed to be distinguished between metastatic malignancies and infectious diseases. Although there are much similarities in disease characteristics of two cases, patient in case one was diagnosed as acute miliary pulmonary tuberculosis (TB) while patient in case two was diagnosed as metastatic disease. The symptoms and pulmonary foci on CT scan of patient in case one improved distinctly after the immediate anti-TB treatment, but the disease of patient in case two progressed after chemotherapy. These findings caution us that differential diagnosis is crucial and have significance in guiding clinical work.

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Efficacy of Mohs Micrographic Surgery for the Treatment of Dermatofibrosarcoma Protuberans

Cited by 121 publications

References 45 publications

A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

A Rare Breast Tumor: Dermatofibrosarcoma Protuberans

Two Cases of Dermatofibrosarcoma Protuberans

Differential diagnosis of acute miliary pulmonary tuberculosis from widespread-metastatic cancer for postoperative lung cancer patients: two cases

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