Efficacy of mitomycin C in endonasal endoscopic dacryocystorhinostomy

Abstract

There was no statistically significant difference in the success rates of both groups, but MMC seems to have a conspicuous effect on the healing process at the ostium.

Endoscopic dacryocystorhinostomy without mucosal flap : Our experience

“…The overall success rate is 88%which is comparable with the study conducted by Suppapong Tirakunwichcha MD et al with the success rate of 84.6% while using mitomycin 13 .…”

Efficacy of Mitomycin C in Endoscopic Dacryocystorhinostomy: A Systematic Review and Meta-Analysis

“…One study was divided into two comparative groups as it included both primary and revision DCRs. Three studies were done in India [12], [13], [33], 3 in Turkey [11], [30], [32], and 1 each in Iran [15], Finland [34], Egpty [35], Thailand [14], and China [10]. The mean age of patients in most of studies ranged from 32 to 70 years and the percentage of female patients ranged from 42% to 90%.…”

“…The dose of MMC used ranged between 0.2 and 0.5 mg/mL, which was placed on the ostium for 2 to 15 minutes. Silicone tubes were used in five studies [11], [14], [15], [31], [35]. Table 2 presents the characteristics of the included studies.…”

“…In 5 of all the RCTs included in the systematic review, the investigators described a random component in the sequence generation process such as: referring to a random number table [13] or using a computer random number generator [11], [34] or using a random blocks [14], [35]. The remainder did not describe the specific methods of random sequence generation.…”

“…The remainder did not describe the specific methods of random sequence generation. Of 5 RCTs that described their masking or binding, 4 used double-blinding [11], [14], [15], [35] and 1 used single-blinding [13]. All RCTs described the data of missing patients and only one study had missing cases: 6 of 76 (6.6%) [35].…”