Efficacy of milnacipran on poststroke depression on inpatient rehabilitation

Yamakawa, Yuriko; Satoh, Shinji; Sawa, Shunji; Ohta, Hisataka; Asada, Takashi

doi:10.1111/j.1440-1819.2005.01440.x

Cited by 18 publications

(8 citation statements)

References 29 publications

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“…Several studies have shown that both depressive mood and apathy have a negative impact on the capacity of stroke patients to recover ADL 11,20,23,25,26 . Somatic symptoms, including psychomotor retardation, weakness, and lethargy, are important features of depression 13–15 . This observation is consistent with the results of the present multiple regression analysis, in which reduced mood and apathetic state was associated with sitting balance after stroke.…”

Section: Discussionsupporting

confidence: 91%

“…11,20,23,25,26 Somatic symptoms, including psychomotor retardation, weakness, and lethargy, are important features of depression. [13][14][15] This observation is consistent with the results of the present multiple regression analysis, in which reduced mood and apathetic state was associated with sitting balance after stroke. Depressive symptoms were influenced by several factors, such as age 15 and lesion location, 12,26 while the present results also suggest that trunk control, that is, sitting balance, might be an important predictive factor.…”

Section: Discussionsupporting

confidence: 89%

“…Depression has two core symptoms in the DSM‐IV classification: “decline in mood” and “loss of interest (apathy)” 12 . Physical disability among depressed persons is significantly higher than among non‐depressed persons 13–15 . Therefore, we also examined the correlation between sitting balance and these two core symptoms of depression, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients

Hama

Yamashita²,

Shigenobu

et al. 2007

Psychiatry Clin Neurosci

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The aim of the present study was to assess the relationship between sitting balance at an early stage and activities of daily living (ADL) function in 452 stroke patients. The effect of sitting balance on the two core elements of depression (apathy and depressive mood) was also examined. The ability to maintain a sitting position for 10 min (10-min sitting balance) was assessed, along with ADL using the Functional Independence Measurement, and psychological status using the Zung Selfrating Depression Scale (depressive mood), Apathy Scale (apathy) and Neuropsychiatric Inventory. Proportional-hazards analysis was used to determine the independent effect of post-stroke depression on functional outcome. Comparisons between sitting balance and psychological status were performed using logistic multiple regression analysis. Cox multiple regression analysis showed that significant differences were obtained for the sitting balance (P < 0.0002) and Mini-Mental State Examination scores (P < 0.02) in all six ADL subscales, and for age in four of the six ADL subscales (Dressing-Upper Body and Dressing-Lower Body, Toileting, Walking). Kaplan-Meier survival curves for reaching independence in ADL subscales showed highly significantly differences in achievement rate and time to reach goal for each subgroup on 10-min sitting balance (with or without assistance) and on age (young, <65; elderly, Ն65 years). Ten-minute sitting balance correlated with depressive mood and apathy. A rapid and simple screening method, 10-min sitting balance was related to scores for two core depressive symptoms, lowered mood and apathy, and was predictive of post-stroke ADL outcomes in the rehabilitation unit along with age.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sitting balance as an early predictor of functional improvement in association with depressive symptoms in stroke patients

Hama

Yamashita²,

Shigenobu

et al. 2007

Psychiatry Clin Neurosci

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“…Lastly, there are few studies on the usefulness of new dual-agents SNRIs (serotonin and norepinephrine reuptake inhibitors), as venlafaxine or milnacipran and duloxetine (Dahmen et al 1999; Yamakawa et al 2005), but methodological problems (open-label studies and with small case-series) reduce the power of these data.…”

Section: Other Studiesmentioning

confidence: 99%

Epidemiology and treatment of post-stroke depression

Paolucci¹

2008

NDT

214

155

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Mood depression is a common and serious complication after stroke. According to epidemiological studies, nearly 30% of stroke patients develop depression, either in the early or in the late stages after stroke. Although depression may affect functional recovery and quality of life after stroke, such condition is often ignored. In fact, only a minority of patients is diagnosed and even fewer are treated in the common clinical practice. Moreover, the real benefi ts of antidepressant (AD) therapy in post-stroke depression have not been fully clarifi ed. In fact, controlled studies on the effectiveness of ADs in post stroke depression (PSD) are relatively few. Today, data available suggest that ADs may be generally effective in improving mood, but guidelines for the optimal treatment and its length are still lacking.

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“…The impact of carotid disease on HRQoL has been mainly investigated for its serious form, stroke, and not for amaurosis fugax and transient ischaemic attack (TIA). Stroke often causes impairment of physical, cognitive, emotional, behavioural and social functions, which negatively affect quality of life 3 4. In most studies HRQoL scores were lower in patients with a stroke than in the general population 3 5–7.…”

Section: Introductionmentioning

confidence: 99%