Efficacy of microneedle radiofrequency therapy in the treatment of senile purpura: A prospective study

Abstract

Background: Radiofrequency (RF) devices have been used for skin rejuvenation and treating skin laxity. It may also be effective for senile purpura (SP) based on its action of promoting neocollagenesis with minimal epidermal damage. This study aimed to evaluate the efficacy and safety of microneedle RF for treating SP of the forearms in elderly. Material and methods:In this prospective study, 23 patients who underwent a single session of microneedle RF device (GENIUS, Lutronic Co., Korea) therapy for SP were enrolled. Histopathological features were assessed 1 week before and 8 weeks after therapy. The total amount of collagen and elastic fibers were measured using the computer vision method, and epidermal thickness and the number of blood vessels were analyzed using ImageJ. The clinical improvements were evaluated by blinded evaluators and the patients using investigator global assessment (IGA) and patient global assessment (PGA), respectively. Data regarding the number of purpuric lesions and the size of the largest lesion were collected via a telephone survey. Results:The total amount of collagen and elastic fibers, and mean epidermal thickness tended to improve after RF treatments, although they did not reach statistical significance. The locally estimated scatterplot smoothing curve showed decreasing tendency in both size and number of purpuras as weeks progressed. PGA showed very satisfied in 65% of patients and IGA showed 39% near-total improvement and 43% marked improvement. There were no serious adverse events. Conclusions:Microneedle RF therapy induces remodeling of dermal circumstances with minimal epidermal impairment. It may be a promising therapeutic option for SP.

Evaluation of short‐term face rejuvenation effects of non‐ablative bipolar radiofrequency treatment performed by Med‐RF©device

“…59 It has been reported that the RF treatment, induces inflammatory reactions starting from immediately after treatment, which triggers the neocollagenesis as a caused by the heat distress protein generation and dermal remodeling. [60][61][62] So, the RF is a technique that meets the demands of patients seeking minimally invasive methods to remodel adipose tissue and tighten skin. Many clinical studies show the ability of the RF therapy for aesthetic skin tightening of the face and body.…”

“…A recent research showed that RF improves skin laxity and determines gene activation in a panel of proteins that are relevant in the extracellular matrix of dermal connective tissue 59 . It has been reported that the RF treatment, induces inflammatory reactions starting from immediately after treatment, which triggers the neocollagenesis as a caused by the heat distress protein generation and dermal remodeling 60–62 . So, the RF is a technique that meets the demands of patients seeking minimally invasive methods to remodel adipose tissue and tighten skin.…”

Recent Advances in Microneedling-Assisted Cosmetic Applications

“…The depth of the needles can be adjusted from 0.5 to 3.5 mm [98]. The RF energy heats the skin to 65-70 • C, without thermally damaging the epidermis [97,99]. The insulated needles penetrate the epidermis with minimal heating while effectively delivering the desired energy to predetermined depths [99].…”

Treatment of periorbital hyperpigmentation using sublative fractional radiofrequency (SFR)

“…In non‐ablative fractional laser therapy, fragmental thermal damage is stimulated in exposed skin. Radiofrequency (RF) is rapidly EVOLVING field update 9–11 . In treatment by RF, the usage of radiofrequency electromagnetic waves makes local hyperthermia via changing electrical energy to intracellular heat with individual skin structures absorption.…”

“…Radiofrequency (RF) is rapidly EVOLVING field update. 9 , 10 , 11 In treatment by RF, the usage of radiofrequency electromagnetic waves makes local hyperthermia via changing electrical energy to intracellular heat with individual skin structures absorption. The dose of light and wavelength are regulated to change the skin‐coloring, decrease erythema, and to the photo‐rejuvenation of ageing.…”