Efficacy of microfiltration in decreasing propofol‐induced pain*

Davies, Alexandra; Vadodaria, B.; Hopwood, Barbara; Dexter, T.; Conn, David

doi:10.1046/j.1365-2044.2002.02602.x

Cited by 19 publications

(15 citation statements)

References 16 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Presently, the most commonly used method in clinical practice is a combination of drugs to prevent propofol injection pain, of which lidocaine is the most widely used. However, several studies have proven that lidocaine may increase the diameter of propofol particles and thus inflict pulmonary embolism 11. Additionally, a combination of lidocaine and propofol may damage the stability of propofol emulsion, thus limiting the effect of lidocaine.…”

Section: Discussionmentioning

confidence: 99%

Effects of dezocine on prevention of propofol injection pain: a meta-analysis

Zhou

Yang

Zhu

et al. 2017

JPR

View full text Add to dashboard Cite

ObjectiveThe objective of this study was to evaluate the effects of dezocine on the prevention of propofol injection pain.Materials and methodsWe searched for randomized controlled trials (RCTs) of dezocine in preventing propofol injection pain, from inception to April 2016, in PubMed, Embase, Cochrane Library, and CNKI. Next, two reviewers independently screened literature, extracted data, and assessed quality in accordance with the inclusion and exclusion criteria. Finally, RevMan 5.2 software was used to conduct a meta-analysis.ResultsSeven RCTs totaling 630 patients were included in this meta-analysis. The meta-analysis study showed: 1) compared with the control group (relative risk [RR] =0.32, 95% CI [0.26, 0.39], P<0.00001), the dezocine group showed a decreasing incidence of propofol injection pain; 2) for severity of propofol injection pain, incidences of mild pain (RR =0.55, 95% CI [0.40, 0.75], P=0.0001), moderate pain (RR =0.28, 95% CI [0.18, 0.43], P<0.00001), and severe pain (RR =0.11, 95% CI [0.06, 0.23], P<0.00001) were considerably lower in the dezocine group than in the control group; 3) when comparing the incidence of propofol injection pain in the dezocine group with that of the lidocaine group, no statistically significant differences were found (RR =0.86, 95% CI [0.66, 1.13], P=0.29); and 4) subgroup analysis indicated a significant reduction in the incidence of propofol injection.ConclusionDezocine can both prevent propofol injection pain and mitigate its severity, and its efficacy shows no significant difference from that of lidocaine.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of dezocine on prevention of propofol injection pain: a meta-analysis

Zhou

Yang

Zhu

et al. 2017

JPR

View full text Add to dashboard Cite

show abstract

“…This VRS method had already been used in other studies that evaluated propofol injection pain. 15–17 The occurrence of pain was defined as any patient with a VRS greater than 0. When the clinical trial was finished, anaesthesia was induced by administration of propofol 1.5 mg kg −1 , fentanyl 5 μg kg −1 , and vecuronium 0.1 mg kg −1 .…”

Section: Methodsmentioning

confidence: 99%

Influence of polyvinyl chloride infusion extension tube on propofol injection pain

Zhang

Shen

et al. 2014

European Journal of Anaesthesiology

View full text Add to dashboard Cite

BACKGROUNDPropofol injection pain is a common and unsolved anaesthesia problem.OBJECTIVESThe present study attempted to confirm that the plasticiser di(2-ethylhexyl) phthalate in polyvinyl chloride (PVC) infusion tubes may increase propofol injection pain by increasing the aqueous propofol concentration.DESIGNA randomised controlled study.SETTINGUniversity teaching hospital, 1 April to 25 June 2013.PATIENTSOne hundred patients scheduled for elective surgery were allocated randomly to the PVC or the control (C) group. The PVC group received a propofol (Diprivan) infusion via a 1-m PVC infusion extension tube, whereas group C received propofol injected directly through the port of the cannula.INTERVENTIONAfter the syringe was loaded with propofol, air was expelled from the tube and the syringe was left standing for 5 min; intravenous propofol 0.5 mg kg−1 was then injected either through the PVC tube or directly into the cannula.MAIN OUTCOME MEASUREA verbal rating scale was used to evaluate the propofol injection pain in both groups. Di(2-ethylhexyl) phthalate and aqueous propofol concentrations were also measured in samples of propofol after simulated injection. To investigate whether the increase in aqueous propofol concentration was caused by leached di(2-ethylhexyl) phthalate, the same amount of di(2-ethylhexyl) phthalate as that measured in the PVC group was added to the samples (group D).RESULTSThe incidences of pain in groups PVC and C were 88 and 46%, respectively (P < 0.0001). The di(2-ethylhexyl) phthalate concentration in group PVC (1.01 ± 0.07 μg ml−1) was greater than that in group C (lower than the detection limit of 0.03 μg ml−1). No significant difference was found between the aqueous propofol concentrations in groups PVC (25.9 ± 1.8 μg ml−1) and D (24.4 ± 1.1 μg ml−1) (P = 0.22), which were significantly higher than that in group C (14.3 ± 1.0 μg ml−1) (P = 0.079).CONCLUSIONPropofol injection pain is increased by contact with PVC infusion tubing as a result of an increase in aqueous propofol concentration caused by di(2-ethylhexyl) phthalate leaching into the lipid emulsion.TRIAL REGISTRATIONchictr.org identifier: ChiCTR-TRC-12003170.

show abstract

“…Much preliminary research has investigated the methods used to prevent or relieve propofol injection-related pain; these methods include nondrug approaches such as choosing a thicker vein (8), slowing injection speed (9), dilution (10,11), microfiltration (12), cooling the propofol (13), and topical EMLA use (14), as well as drug interventions, such as the use of lidocaine (15), opioids (16), sedatives (17,18), muscle relaxants (19), and nonsteroidal antiinflammatories (20,21), among others. A metaanalysis published in 2011 indicated that the most effective methods are selection of a thicker vein and prophylactic preinjection of lidocaine combined with vein occlusion (4).…”

Section: Discussionmentioning

confidence: 99%

Prevention of propofol injection-related pain using pretreatment transcutaneous electrical acupoint stimulation

Huang¹,

Pan²,

Chen³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim: This study aimed to study the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain.Materials and methods: A total of 360 patients who were to undergo elective hysteroscopy surgery were randomly divided into the following three groups of 120 patients each: control (Group C), sham TEAS (Group F), and TEAS (Group T). Patients in Group C did not undergo any treatment before surgery; 30 min before the induction of anesthesia, patients in Groups F and T underwent electrical stimulation of the bilateral LI4-PC6 acupoint. Patients in Group F were subjected to "feeling flow", while those in Group T were subjected to "tolerance flow. " The stimulation frequency was 2/100 Hz and the duration of stimulation was 30 min. After the induction of anesthesia, propofol injection-related pain scores, hemodynamic parameters, and adverse reactions were recorded.Results: Of the 360 patients, 324 completed the study. There were significant differences among the groups in terms of the incidence of moderate-to-severe pain. In terms of the four-point scaling method, the end of the radial vein, the cubital vein, and the "back of the hand" vein differed significantly among the three groups (P = 0.05). Finally, using a numerical rating scale, a significant difference was observed among the three groups in terms of the pain scores in the different veins.Conclusions: Pretreatment TEAS effectively reduces the incidence and severity of propofol injection-related pain, the incidence of postoperative nausea and vomiting, and patient postoperative pain scores.

show abstract

Efficacy of microfiltration in decreasing propofol‐induced pain*

Cited by 19 publications

References 16 publications

Effects of dezocine on prevention of propofol injection pain: a meta-analysis

Effects of dezocine on prevention of propofol injection pain: a meta-analysis

Influence of polyvinyl chloride infusion extension tube on propofol injection pain

Prevention of propofol injection-related pain using pretreatment transcutaneous electrical acupoint stimulation

Contact Info

Product

Resources

About