Efficacy of metoprolol in treatment and preventive of cardiovascular diseases

Евгеньевна, Чазова Ирина; Геннадиевна, Ратова Людмила; Ratova, L G; Чазова, И Е

doi:10.26442/sg28841

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Thus, moderate/severe CTD in patients with CM of urinary system were associated with comparatively higher plasma concentrations of renin and aldosterone, development of nephrosclerosis and AH. [8]. Ангиотензин II способствует продукции цитокинов (в том числе TNFα) и факторов роста [4].…”

Section: ключевые слова: органы мочевой системы пороки развития дисплазия соединительной ткани ренин альдостеронmentioning

confidence: 99%

On the mechanisms of progression of congenital developmental anomalies of urinari organs on the background of connective tissue displasia

Mambetova¹,

Inarokova²,

Shabalova³

et al. 2016

Medical news of the North Caucasus

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Оригинальные исследОвания ДСТ в педиатрии в рождённые пороки развития органов мочевой системы (вПр омС) занимают в структуре терминальной хронической почечной недостаточности у детей одно из ведущих мест [2], являются фактором риска формирования хронической болезни почек (ХБП) [7, 9, 10].В механизмах формирования вторичных осложнений и их прогрессировании при ХБП принимают участие компоненты ренин-ангиотензин-альдосте-роновой системы [7,10]. Ангиотензин II и альдостерон не только участвуют в вазомоции и регуляции баланса Na и К, но и действуют как факторы роста, стимулируя продукцию трансформирующего фактора роста β, синтез коллагена I типа и фиброгенез [1,6].Установлено, что все дети с ВПР ОМС имеют дисплазию соединительной ткани (ДСТ) с неклассифицируемым фенотипом [5]. Используя предложен-

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confidence: 99%

On the mechanisms of progression of congenital developmental anomalies of urinari organs on the background of connective tissue displasia

Mambetova¹,

Inarokova²,

Shabalova³

et al. 2016

Medical news of the North Caucasus

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“…AH was diagnosed according to recommendations on AH given by the Russian Medical Society for Arterial Hypertension (the 4 th edition) [8]. To initially screen GERD, we applied GerdQ questionnaire (method sensitivity is 91.7 %; method specificity, 65.4 %) which allowed diagnosing GERD during an initial contact with a patient [9].…”

mentioning

confidence: 99%

TNF gene polymorphism as a risk factor that can cause arterial hypertension in patients suffering from gastroesophageal reflux disease

Khlynova¹,

Shishkina²,

Сахена³

et al. 2020

Health Risk Analysis

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Comorbidity of arterial hypertension (AH) and gastroesophageal reflux disease (GERD) is widely spread (from 20.6 % to 29 %); despite that fact, risk factors that can cause AH in patients suffering from GERD have still not been examined completely. Experts are discussing a role played by anti-inflammation cytokine of tumor necrosis factor alpha (TNF) both in AH occurrence and GERD pathogenesis as it is its activity that is to a great extent determined by a patient having certain alleles of tumor necrosis factor (TNF) gene. Therefore, it seems vital to study TNF gene G308A polymorphism in patients with combined AH and GERD.Our research goal was to study frequency and variants of TNF gene G308A polymorphism relations with AH risk and AH phenotypic peculiarities in patients suffering from GERD.We examined 58 people who had AH (29 patients with isolated AH, average age being 53 [46; 62], and 29 patients with combined AH and GERD, average age being 56 [51; 59]). Patients from both groups were comparable in terms of sex, age, and examined factors of cardiovascular diseases risks. We applied allele-specific polymerase reaction with test systems produced by "Sintol" LLC (Moscow) to determine G308A (rs1800629) polymorphism of TNF gene. To assess relations between alleles and genotypes and disease risks, we calculated odds ratio (OR) with 95 % confidence interval (CI).We revealed a relation between G308A polymorph marker of TNF gene and systolic blood pressure and disorders in tolerance to dextrose among patients with comorbid AH and GERD.

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Efficacy of metoprolol in treatment and preventive of cardiovascular diseases

Cited by 2 publications

References 8 publications

On the mechanisms of progression of congenital developmental anomalies of urinari organs on the background of connective tissue displasia

On the mechanisms of progression of congenital developmental anomalies of urinari organs on the background of connective tissue displasia

TNF gene polymorphism as a risk factor that can cause arterial hypertension in patients suffering from gastroesophageal reflux disease

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