Efficacy of Marlex Mesh on Posterior Fixation Suture: An Experimental Study in a Rabbit Model

Yang, Hee Kyung; Han, Sang Beom; Choe, Gheeyoung; Hwang, Sang Won; Lee, Yeon Hee; Hwang, Jeong‐Min

doi:10.1016/j.ajo.2010.06.044

Cited by 2 publications

(8 citation statements)

References 30 publications

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“…However, Marlex mesh induced diffuse fibrotic adhesions in nearby tissues which may cause restriction to the opposite direction and difficulties in reoperation (Yang et al. ). This feature serves as a suitable animal model for restrictive strabismus.…”

Section: Discussionmentioning

confidence: 99%

“…) (Yang et al. ). The superior rectus was sutured back to its original insertion using absorbable 7‐0 polyglactin sutures (7‐0 Vicryl; Ethicon).…”

Section: Methodsmentioning

confidence: 99%

“…The maximal tensile strength required to separate myoscleral union was measured before enucleation at 4 weeks postoperatively using a push pull gauge (Yang et al. ). A masked observer (HKY) independently performed the following measurement.…”

Section: Methodsmentioning

confidence: 99%

“…Traction force was gradually increased in the perpendicular direction to the muscle, and the maximum traction force was recorded (Yang et al. ).…”

Section: Methodsmentioning

confidence: 99%

“…The Marlex mesh was trimmed to 5.0 9 5.0 mm size and each piece was fixed beneath the superior rectus muscle using 5-0 polyester sutures (5-0 Ethibond; Ethicon, Somerville, MA, USA), with the sutures passing through the sclera, Marlex mesh and then the muscle belly in order (Fig. 1) (Yang et al 2011). The superior rectus was sutured back to its original insertion using absorbable 7-0 polyglactin sutures (7-0 Vicryl; Ethicon).…”

Section: Surgical Proceduresmentioning

confidence: 99%

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Efficacy of collagen matrix implant on adhesions in restrictive strabismus: An experimental study in a rabbit model

Yoo

Hwang

Choe

et al. 2018

Acta Ophthalmologica

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Purpose: To determine the efficacy of a biodegradable collagen matrix implant (Ologen, Aeon Astron Europe BV, Leiden, the Netherlands) in reducing adhesions in a rabbit model of restrictive strabismus. Methods: A prospective, masked-observer, controlled experimental study was performed. Sixty superior rectus muscles of 30 rabbits were resected and Marlex mesh was fixed beneath the resected muscle using nonabsorbable suture. Forty eyes underwent one of two different procedures; the resected muscle was wrapped with preserved human amniotic membrane (AM group) or Ologen (Ologen group). Randomly selected 20 eyes served as controls. Eyes were enucleated at 4 weeks after surgery to measure the severity of adhesion using a push pull gauge. Histopathological examination was performed. Results: At postoperative week four, the average tensile strength of the myoscleral adhesion was significantly lower in the Ologen group (151.8 AE 42.7 gram force) compared to controls (347.9 AE 68.6 gram force) and AM group (193.0 AE 44.3 gram force) (p < 0.001 and p = 0.045, respectively). Ologen group showed significantly lower degree of acute inflammation, chronic inflammation and rectus muscle fibrosis compared with controls (all p < 0.01). The degree of chronic inflammation was significantly lower in the Ologen group compared with AM group (p = 0.012). Conclusion: Compared to amniotic membrane, Ologen is more effective in reducing mesh-related extraocular muscle adhesions in a rabbit model of restrictive strabismus.

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Section: Discussionmentioning

confidence: 99%

“…) (Yang et al. ). The superior rectus was sutured back to its original insertion using absorbable 7‐0 polyglactin sutures (7‐0 Vicryl; Ethicon).…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Traction force was gradually increased in the perpendicular direction to the muscle, and the maximum traction force was recorded (Yang et al. ).…”

Section: Methodsmentioning

confidence: 99%

Section: Surgical Proceduresmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of collagen matrix implant on adhesions in restrictive strabismus: An experimental study in a rabbit model

Yoo

Hwang

Choe

et al. 2018

Acta Ophthalmologica

Self Cite

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Histopathologic Change in the Anterior Part of the Posterior Fixation Suture After a Faden Operation in an Animal Model

Kim,

Kang,

Kang

et al. 2024

J Pediatr Ophthalmol Strabismus

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Purpose: To observe postoperative histological changes in the anterior part of the posterior fixation suture after a Faden operation in an animal model. Methods: A posterior fixation suture was placed at two points 6 mm posterior to the insertion of the extraocular muscle on the superior rectus muscle of the right eye in eight rabbits. The superior rectus muscle of the left eye was used as a control. The eyes were enucleated and the anterior portion of the posterior fixation suture, including the myoscleral junction, was extracted 4 weeks after surgery. Postoperative adhesion was graded from 0 to 4 based on histologic findings (hematoxylin–eosin and Masson's trichrome staining). Results: Histological evaluation revealed diffuse fibrosis at the myoscleral junction and the anterior part of the posterior fixation suture after the Faden operation. The graded scores for fibrosis, acute inflammation, chronic inflammation, and foreign body reactions in the Faden operation group were significantly higher than those in the control group ( P < .05). Postoperative diffuse fibrosis of the myoscleral junction and anterior-to-posterior fixation sutures were observed in an animal model. Conclusions: Histologic changes may affect ocular alignment and motility, making reoperation unpredictable after the Faden procedure. [ J Pediatr Ophthalmol Strabismus . 20XX;X(X):XX–XX.]

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Efficacy of Marlex Mesh on Posterior Fixation Suture: An Experimental Study in a Rabbit Model

Cited by 2 publications

References 30 publications

Efficacy of collagen matrix implant on adhesions in restrictive strabismus: An experimental study in a rabbit model

Efficacy of collagen matrix implant on adhesions in restrictive strabismus: An experimental study in a rabbit model

Histopathologic Change in the Anterior Part of the Posterior Fixation Suture After a Faden Operation in an Animal Model

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