Efficacy of Marigold Extract-Loaded Formulations Against UV-induced Oxidative Stress

Fonseca, Yris Maria; Catini, Carolina Dias; Vicentini, Fabiana T. M. C.; Cardoso, Juliana Cordeiro; Albuquerque, Ricardo Luiz Cavalcanti de; Fonseca, Maria José Vieira

doi:10.1002/jps.22438

Cited by 35 publications

(25 citation statements)

References 42 publications

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“…It has been demonstrated that the rutin is able to impair the glycation of collagen [31], a biochemical event involved in the pathogenesis of cell damaging in UV-irradiated tissue [32]. …”

Section: Discussionmentioning

confidence: 99%

UVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract

Serafini

Detoni

Menezes

et al. 2014

BioMed Research International

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Exposure to solar radiation, particularly its ultraviolet (UV) component, has a variety of harmful effects on human health. Some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. The beneficial photoprotective effects of topical formulations with the extract, Morinda citrifolia, have not been investigated. This present study aims to investigate the potential benefits of M. citrifolia topical application on the dorsal skin of mice, exposed to UVA-UVB light. Using 7 days of treatment, [before (baseline values) and 20 h after UV exposure], the thickness, skin barrier damage (TEWL), erythema, and histological alterations were evaluated. The results showed that the formulations containing the extract protected the skin against UV-induced damage.

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“…It has been demonstrated that the rutin is able to impair the glycation of collagen [31], a biochemical event involved in the pathogenesis of cell damaging in UV-irradiated tissue [32]. …”

Section: Discussionmentioning

confidence: 99%

UVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract

Serafini

Detoni

Menezes

et al. 2014

BioMed Research International

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“…Therefore, adequate cutaneous absorption is known to be an essential requirement for topically applied photoprotective agents [181], and the vehicle in which the drug is applied could effectively influence its release from a topical pharmaceutical preparation [177]. When a delivery system is applied topically to the skin, the active agent must be released from its carrier (vehicle) before it contacts the epidermal surface and be available for penetration into the SC and lower layers of the skin [182,183].…”

Section: Development Of Topical Formulations Containing Flavonoidsmentioning

confidence: 99%

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Verri

Vicentini

Baracat

et al. 2012

Bioactive Natural Products

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106

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“…2 Induction of reactive oxygen species and free radicals above the physiological limits of the natural antioxidant defense mechanism in the skin lead to skin damage, including erythema, photoaging, and skin cancer. 3,4 Prolonged exposure to solar ultraviolet radiation activates biochemical reactions in human skin that cause depletion of cellular antioxidants and antioxidant enzyme producers, leading to a state of oxidative stress. Oxidative stress is a state of fragmented cellular DNA and membrane damage that can lead to death of cells and tissues due to protein denaturation and lipid peroxidation caused by reactive oxygen species and free radicals.…”

Section: Introductionmentioning

confidence: 99%

“…Novel photoprotective approaches are increasingly being used to prevent photodamage and to ameliorate sun-induced skin damage by prevention of penetration of ultraviolet radiation into the skin. [2][3][4] Topically applied antioxidants can directly enrich the natural antioxidant defense system and prevent/reduce oxidative damage to the skin. 7 Phyllanthus urinaria is a herbal plant belonging to the genus Phyllanthus, family Euphorbiaceae.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

Mahdi¹,

Noor²,

Sakeena³

et al. 2011

IJN

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Background Recently there has been a remarkable surge of interest about natural products and their applications in the cosmetic industry. Topical delivery of antioxidants from natural sources is one of the approaches used to reverse signs of skin aging. The aim of this research was to develop a nanoemulsion cream for topical delivery of 30% ethanolic extract derived from local Phyllanthus urinaria ( P. urinaria ) for skin antiaging. Methods Palm kernel oil esters (PKOEs)-based nanoemulsions were loaded with P. urinaria extract using a spontaneous method and characterized with respect to particle size, zeta potential, and rheological properties. The release profile of the extract was evaluated using in vitro Franz diffusion cells from an artificial membrane and the antioxidant activity of the extract released was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Results Formulation F12 consisted of wt/wt, 0.05% P. urinaria extract, 1% cetyl alcohol, 0.5% glyceryl monostearate, 12% PKOEs, and 27% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and a 59.5% phosphate buffer system at pH 7.4. Formulation F36 was comprised of 0.05% P. urinaria extract, 1% cetyl alcohol, 1% glyceryl monostearate, 14% PKOEs, 28% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and 56% phosphate buffer system at pH 7.4 with shear thinning and thixotropy. The droplet size of F12 and F36 was 30.74 nm and 35.71 nm, respectively, and their nanosizes were confirmed by transmission electron microscopy images. Thereafter, 51.30% and 51.02% of the loaded extract was released from F12 and F36 through an artificial cellulose membrane, scavenging 29.89% and 30.05% of DPPH radical activity, respectively. Conclusion The P. urinaria extract was successfully incorporated into a PKOEs-based nanoemulsion delivery system. In vitro release of the extract from the formulations showed DPPH radical scavenging activity. These formulations can neutralize reactive oxygen species and counteract oxidative injury induced by ultraviolet radiation and thereby ameliorate skin aging.

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Efficacy of Marigold Extract-Loaded Formulations Against UV-induced Oxidative Stress

Cited by 35 publications

References 42 publications

UVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract

UVA-UVB Photoprotective Activity of Topical Formulations ContainingMorinda citrifoliaExtract

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

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