Efficacy of lycopene‐enriched virgin olive oil for treating burning mouth syndrome: a double‐blind randomised

Abstract

Burning mouth syndrome (BMS) is an intensive chronic oral mucosal pain condition of unknown aetiology. The aim of this study was to evaluate the clinical performance of lycopene-enriched virgin olive oil used to treat the condition, comparing this with a placebo. This study took the form of a double-bind, randomised clinical trial. A total of 60 patients with BMS were randomly divided into two groups: Group I (n = 30) treated with lycopene-enriched virgin olive oil (300 ppm) (1.5 mL three times a day) and Group II (n=treated with a placebo (1.5 mL three times a day). Evaluations were made before and after 12 weeks of product/placebo application. Symptoms were evaluated by VAS, whilst patient psychological profiles were assessed using the HAD scale and patient quality of life using the Oral Health Impact Profile-14 (OHIP-14) and the Medical Outcome Short Form Health Survey questionnaire (SF36). Fifty patients completed the 12-week treatment (26 in Group I and 24 in Group II). Visual analogue scale pain values improved in both groups but without statistically significant differences between the groups (P = 0.57). Oral quality of life also improved. Four patients in Group I (treatment) left the study and six left Group II (placebo). No patients experienced any adverse effects resulting from treatment at any of the evaluation times. Patients were lost from the sample due to lack of compliance. It was found that the lipid profile did not change during the 3-month study period as a result of the application of lycopene-enriched olive oil (Group I); nor did any change occur in the placebo group (Group II). In this way, the placebo effect was seen to be strong. The topical lycopene-enriched virgin olive oil is a very safe and an effective similar way that the placebo for treating patients with BMS. However, future studies are required to establish the treatment for patients with chronic and painful syndrome.

Effect of oil pulling in promoting oro dental hygiene: A systematic review of randomized clinical trials

“…1). Eleven studies, [14][15][16][17][18][19][20][21][22][23][24] were excluded because conventional oil pulling was not part of the intervention, and four 25-28 because they were not RCTs. One study 29 was excluded because conventional cooking oil was not used as intervention, and another 30 because it was a nonhuman study.…”

World Workshop in Oral Medicine VII: Reporting of IMMPACT‐recommended outcome domains in randomized controlled trials of burning mouth syndrome: A systematic review

“…2 (5.6%) Patient‐rated benefit, satisfaction, tolerability of treatment (Cano‐Carrillo et al, ; Treldal et al, )…”

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

“…In this systematic review, nearly 75% of the RCTs used an existing BMS definition to guide case selection (Cavalcanti & da Silveira, ; Femiano, ; Femiano & Scully, ; Gremeau‐Richard, Dubray, Aublet‐Cuvelier, Ughetto, & Woda, ; Gremeau‐Richard et al., ; Lopez‐Jornet, Camacho‐Alonso, & Andujar‐Mateos, ; Marino, Torretta, Capaccio, Pignataro, & Spadari, ; Petruzzi, Lauritano, De Benedittis, Baldoni, & Serpico, ; Sardella et al., , ; Spanemberg, Lopez Lopez, de Figueiredo, Cherubini, & Salum, ; Spanemberg et al., ), most commonly that by IASP (Cano‐Carrillo, Pons‐Fuster, & Lopez‐Jornet, ; Cavalcanti & da Silveira, ; Gremeau‐Richard et al., ; Jorgensen & Pedersen, ; Lopez‐Jornet et al., ; Marino et al., ; Palacios‐Sánchez, Moreno‐Lopez, Cerero‐Lapiedra, Llamas‐Martinez, & Esparza‐Gomez, ; Sardella et al., ; Silva, Siqueira, Teixeira, & Siqueira, ; Spanemberg et al., ; Umezaki et al., ) or IHS (Arduino et al., ; Carbone, Pentenero, Carrozzo, Ippolito, & Gandolfo, ; Jurisic Kvesic et al., ; Lopez‐Jornet, Camacho‐Alonso, & Leon‐Espinosa, ; López‐Jornet, Camacho‐Alonso, & Molino‐Pagan, ; Tammiala‐Salonen & Forssell, ; Valenzuela & Lopez‐Jornet, ; Valenzuela, Pons‐Fuster, & Lopez‐Jornet, ). However, the most current BMS definition by IASP and IHS differs (IASP, ; IHS, ).…”