Efficacy of &lt;b&gt;&lt;i&gt;Melissa officinalis&lt;/i&gt;&lt;/b&gt; in Suppressing Ventricular Arrhythmias following Ischemia-Reperfusion of the Heart: A Comparison with Amiodarone

Joukar, Siyavash; Zarisfi, Zahra; Sepehri, Gholamreza; Bashiri, Alireza

doi:10.1159/000363452

Cited by 37 publications

(38 citation statements)

References 24 publications

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“…and some antipsychotic agents (Chlorpromazine, Droperidol, Haloperidol, Mesoridazine, Pimozide, Thioridazine and etc.) [21,130,131], should be used with caution. Moreover, from the perspective of opioid substitution, other issues such as the potency of the drug, its availability and patient preference are important and can affect physician prescription [132].…”

Section: Discussionmentioning

confidence: 99%

Opioids and Cardiac Arrhythmia: A Literature Review

2018

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Objective: One of the most important side effects of opioids is their influence on the electrical activity of the heart. This review focusses on the effects of opioids on QT interval prolongation and their arrhythmogenic liability. Methods: By using various keywords, papers published up to 2018 in different databases were searched and identified. The search terms were opioids names, corrected QT interval, human-ether-a-go-go gene, torsades de pointes (TdP), cardiac arrhythmias, opioid dependence and other relevant terms. It emphasized the effects of each opioid agent alone on electrocardiogram (ECG) and some interactions. Results: Available data indicate that some opioids such as methadone are high-risk even at low doses, and have potential for prolongation of the QT interval and development of TdP, a dangerous ventricular tachycardia. A number of opioids such as tramadol and oxycodone are intermediate risk drugs and may develop long QT interval and TdP in high doses. Some other opioids such as morphine and buprenorphine are low-risk drugs and do not produce QT interval prolongation and TdP at least in routine doses. Opium-consumers are at higher risk of supra-ventricular arrhythmias, sinus bradycardia, cardiac block and atrial fibrillation. Conclusion: The cardiac arrhythmogenicity of various opioids is different. Methadone has a higher capability to induce long QT interval and dangerous arrhythmias in conventional doses than others. To reduce of arrhythmogenic risk, high doses of opioids must be used cautiously with periodic monitoring of ECG in high-risk consumers such as patients under opioid maintenance treatment.

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Section: Discussionmentioning

confidence: 99%

Opioids and Cardiac Arrhythmia: A Literature Review

2018

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“…Saffron groups, Saf50, Saf100 and Saf200, were fed with the aqueous extract of saffron by gavage for 7 days at dosages of 50, 100 and 200 mg/mL/kg/d, respectively. Finally, the Amio group, positive control group, orally was treated with 30 mg/mL/kg/d of amiodarone, for 7 days . Based on the Singh‐Vaughan Williams classification, amiodarone is a class 3 of antiarrhythmic agent and used for various types of cardiac dysrhythmias.…”

Section: Methodsmentioning

confidence: 99%

The safety assessment of saffron (Crocus sativus L.) on sympathovagal balance and heart rate variability; a comparison with amiodarone

Joukar

Dehesh

2015

Auton Autocoid Pharmacol

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Dry stigmas of the Crocus sativus L. (Saffron) are well known in world as a popular flavouring and therapeutic agent. The anxiolytic, antidepressant, anticonvulsant and antiarrhythmic effects of saffron suggest that it may affect the autonomic control of the heart. This study assessed its safety on cardiac sympathovagal balance and heart rate variability in rat. Experimental groups were control, Saf50, Saf100, Saf200 (received saffron at dosages of 50 and 100 and 200 mg/kg/d, orally, respectively) and Amio (received 30 mg/mL/kg/d of amiodarone, orally, for 7 days) groups. On day 8, the frequency domain and time domain indices of animals' electrocardiograms were calculated. The heart rate decreased and RR interval increased in Saf200 and Amio groups (P<.05 vs other groups). Square root of the mean squared differences of successive RR intervals enhanced in all treated groups, however, was only significant in Amio group (P<.05). The SD1/SD2 ratio was higher in Saf200 and Amio groups. Both low-frequency (LF) and high-frequency (HF) parameters were higher, and the LF/HF ratio was non-significantly lower in treated groups. The findings suggest that saffron not only has no harmful effect on activity of cardiac autonomic nervous system, but it may improve the stability of heart sympathovagal balance in normal rat.

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“…the time from the beginning of the Q wave to the end of the T wave) were calculated based on 2-minute ECG-recorded strips. To obviate the dependence of the QT interval on HR, corrected QT (QTc) intervals were calculated using Bazett's formula, normalised as QTcn-B=QT / (RR / f) 1/2 , where and f=150 ms (28).…”

Section: Recording Of Ecg Systolic Blood Pressure Heart Rate Shockmentioning

confidence: 99%

Dihydroxyacetone as a definitive treatment for aluminium phosphide poisoning in rats

Ahmadi

Joukar

Anani

et al. 2018

Archives of Industrial Hygiene and Toxicology

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Aluminium phosphide (AlP), a very toxic pesticide also known as the rice tablet, releases phosphine gas upon contact with water, moisture, or gastric acid. Its mortality rate in humans is 70-100 % due to cardiogenic shock and refractory hypotension. Dihydroxyacetone (DHA) is a simple ketonic carbohydrate, mainly used for sunless skin tanning. It also plays a beneficial role in the treatment of hypotension and cardiogenic shock by restoring blood volume and cellular respiration. The aim of this study was to investigate the its effect on the haemodynamics and electrocardiogram (ECG) in male rats poisoned with AlP. The animals were divided into the following groups: control (received 1 mL corn oil, orally), AlP (received 15 mg kg-1 AlP solved in corn oil, orally), AlP plus DHA (treated with 50 mg kg-1 of DHA 30 min after receiving AlP), and AlP plus N-acetyl cysteine (NAC) (treated with 200 mg kg-1 of NAC 30 min after receiving AlP). The animals were then anaesthetised and ECG, blood pressure, and heart rate were recorded for 120 min. Treatment with AlP alone and in combination with NAC was associated with progressive hypotension, tachycardia, and ECG disturbances in rats, resulting in 100 % mortality 3 h after poisoning. However, DHA achieved 100 % survival in the poisoned rats and prevented AlP-induced ECG and haemodynamic abnormalities. The main mechanism of DHA in the treatment of AlP poisoning is unclear, but the findings suggest the promising therapeutic potential of DHA against AlP poisoning.

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Efficacy of <b><i>Melissa officinalis</i></b> in Suppressing Ventricular Arrhythmias following Ischemia-Reperfusion of the Heart: A Comparison with Amiodarone

Cited by 37 publications

References 24 publications

Opioids and Cardiac Arrhythmia: A Literature Review

Opioids and Cardiac Arrhythmia: A Literature Review

The safety assessment of saffron (Crocus sativus L.) on sympathovagal balance and heart rate variability; a comparison with amiodarone

Dihydroxyacetone as a definitive treatment for aluminium phosphide poisoning in rats

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