Efficacy of low-level laser therapy in nerve injury repair—a new era in therapeutic agents and regenerative treatments

Assis, Ana Carolina Correa de; Oliveira, Bruna Stefane Alves de; Ferreira, Luiz Fernando Romanholo; Bilal, Muhammad; Iqbal, Hafiz M.N.; Soriano, Renato Nery

doi:10.1007/s10072-021-05478-7

Cited by 10 publications

(2 citation statements)

References 40 publications

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“…In the realm of medical innovation, the application of photobiomodulation has emerged as a promising approach for treating nerve injuries in the oral district [17][18][19]. The quest to optimize this therapy hinges upon selecting the appropriate laser type and wavelengths.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers delve into the intricate interplay between laser characteristics and their compatibility with the unique anatomical and physiological aspects of the oral nerve network. An exploration of the optimal laser type, such as low-level laser therapy (PBMT), and the most effective wavelengths unfolds as a pivotal pursuit [18,19]. As the medical community strives to unravel the potential of photobiomodulation, questions abound regarding the outcomes that it yields in terms of the recovery of nervous function.…”

Section: Discussionmentioning

confidence: 99%

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Nerve Injury and Photobiomodulation, a Promising Opportunity: A Scoping Review on Laser Assisted Protocols for Lesions in the Oral Region

et al. 2023

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The currently available therapeutic options for restoring function and sensitivity in long-term nervous injuries pose challenges. Microsurgery interventions for direct nerve repair often lead to serious complications and limited success. Non-surgical methods, although somewhat effective, have limited benefits. These methods involve drug administration, such as with analgesics or corticosteroids. Photobiomodulation therapy (PBMT) has emerged as a promising approach based on clinical and laboratory studies. PBMT stimulates the migration and proliferation of neuronal fiber cellular aggregates, as reported in the literature. Experimental studies on animal models with peripheral nerve compression injuries have shown that PBMT can enhance the functionality of damaged nerves, preserving their activity and preventing scar tissue formation. The mechanism of action depends on the wavelength, which can positively or negatively affect photo acceptor resonances, influencing their conformation and activities. These findings suggest that photobiomodulation may accelerate and improve nerve regeneration. This review explores various methodologies used in photobiomodulation for regenerating nerve sensitivity after surgical trauma involving nerve structures, in the oral and peri-oral region. Research was conducted to evaluate which laser-assisted therapeutic protocols are used to improve the recovery of nervous sensitivity, using the JBI methodology for scoping reviews and following the PRISMA methodology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%