Efficacy of Low-Level Laser on Renal Pruritus in Hemodialysis Patients

Emam, Zakaria Mowafy; Abbas, Sami A; Elthakaby, Ahmed H; EL-Hameed, Marwa Mahdy Abd; Farek, Amany Ibrahim Marae

doi:10.21608/ejhm.2020.115637

Cited by 2 publications

(3 citation statements)

References 13 publications

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“…The findings of this study were consistent with those of Emam et al [15] , who came to the conclusion that LLLT can be used to treat pruritus and relieve itching pain. This was supported by the extremely significant reduction in itching VAS and 5-D Pruritus Scale.…”

Section: Discussionsupporting

confidence: 92%

Clinical Efficacy of Phototherapy on Pruritis with Dermatopathic Patients

Mohamed¹,

Toson²,

Omar³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: A frequent skin condition associated with diabetes called diabetic dermopathy may also be associated with neuropathy. The neurological and dermatologic systems are often linked in the pathophysiology of diabetic itch.Objective: This research evaluated the efficacy of low-level laser therapy (LLLT) and polarized light therapy (PLT) in treating diabetes patients' pruritus and dermopathy. Subjects and Methods: This study included forty patients. They were split randomly into two groups with an equal number of people; Group (A): Received low level laser therapy along with medical care (Using antibiotic creams for all patients) for eight weeks; three sessions per week. While, Group (B): Received polarized light along with medical care (Using antibiotic creams for all patients) for eight weeks; three sessions per week. Before and following the treatment, pruritus was measured. Results: This study found no significant differences of low level laser therapy and polarized light therapy in their favourable effects on diabetic dermopathy and itching (p > 0.05). Conclusion: Both low-level laser therapy and polarised light therapy are secure approaches that effectively treat pruritus and dermopathy.

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Section: Discussionsupporting

confidence: 92%

Clinical Efficacy of Phototherapy on Pruritis with Dermatopathic Patients

Mohamed¹,

Toson²,

Omar³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…In a prospective observational study of patients with atopic dermatitis, LLLT led to a reduction of symptoms, including itching [ 40 ]. In a recent small randomized clinical trial in patients with renal pruritus, the combination of LLLT plus antihistamine medication was compared to antihistamines alone [ 41 ]. This study is of particular interest, as based on their data, it can be assumed that LLLT has an effect beyond the histamine pathway.…”

Section: Discussionmentioning

confidence: 99%

“…The transferability of our findings from short-lasting models to clinical practice in the treatment of chronic pruritus is undoubtedly restricted. Nevertheless, our study sheds light on the pathophysiology of a non-pharmacological treatment modality that has been previously evaluated in clinical settings [ 39 – 41 ]. The findings from our study encourages the clinical utilisation of LLLT in the treatment of pruritus, specifically when triggered by histamine.…”

Section: Discussionmentioning

confidence: 99%

The effect of photobiomodulation on histamine and Mucuna pruriens-induced pruritus, hyperknesis and alloknesis in healthy volunteers: A double-blind, randomized, sham-controlled study

Lang-Illievich,

Klivinyi,

Schulze-Bauer

et al. 2024

PLoS ONE

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Background Photobiomodulation, also referred to as Low-Level Light Therapy (LLLT), has emerged as a promising intervention for pruritus, a prevalent and often distressing symptom. Objectives This study investigated the efficacy of low-level light therapy (LLLT) in alleviating pruritus, hyperknesis, and alloknesis induced by histamine and Mucuna pruriens. Methods In a double-blind, randomized, sham-controlled trial with a split-body design, healthy volunteers underwent 6 minutes of LLLT and sham treatments in separate upper back quadrants. The histamine model was applied to the upper quadrants, and Mucuna pruriens to the lower quadrants. Pruritus intensity, alloknesis, hyperknesis, flare area, and skin temperature were measured pre and post treatment. Results Seventeen individuals (eight females, nine males) participated in the study. In the histamine model, LLLT notably reduced itch intensity (difference = 13.9 (95% CI: 10.5 − 17.4), p = 0.001), alloknesis (difference = 0.80 (95% CI: 0.58–1.02), p = 0.001), and hyperknesis (difference = 0.48 (95% CI: 0.09–0.86), p = 0.01). Skin temperature changes were not significantly different between the two groups (difference = -2.0 (95% CI: -6.7–2.6), p = 0.37). For the Mucuna pruriens model, no significant differences were observed in any measures, including itch intensity (difference = 0.8 (95% CI: -2.3 − 3.8), p = 0.61) hyperknesis (difference = 0.08 (95% CI: -0.06–0.33), p = 0.16) and alloknesis (difference = 0. 0.09 (95% CI: -0.08–0.256), p = 0.27). Conclusions LLLT effectively reduced histamine-induced pruritus, alloknesis, and hyperknesis; however, LLLT was ineffective against Mucuna pruriens-induced pruritus. Further investigations are required to determine LLLT’s effectiveness of LLLT in various pruritus models.

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Efficacy of Low-Level Laser on Renal Pruritus in Hemodialysis Patients

Cited by 2 publications

References 13 publications

Clinical Efficacy of Phototherapy on Pruritis with Dermatopathic Patients

Clinical Efficacy of Phototherapy on Pruritis with Dermatopathic Patients

The effect of photobiomodulation on histamine and Mucuna pruriens-induced pruritus, hyperknesis and alloknesis in healthy volunteers: A double-blind, randomized, sham-controlled study

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