Efficacy of local drug delivery of Achyranthes aspera gel in the management of chronic periodontitis: A clinical study

Abstract

Context:Periodontitis is an inflammatory disease of microbial origin. Locally delivered antimicrobials reduce subgingival flora. Achyranthes aspera gel has antimicrobial, antioxidant, anti-inflammatory, and immunostimulant effects.Aims:To evaluate the efficacy of local drug delivery of A. aspera gel in the management of chronic periodontitis.Materials and Methods:Thirty patients with chronic periodontitis were considered in the study and categorized into two equal groups (Group A: scaling and root planing (SRP) with A. aspera gel, Group B: SRP with placebo gel). Patients were enlisted from the Department of Periodontics, Mamata Dental College and Hospital. The clinical parameters (gingival index, bleeding on probing, probing pocket depth, and clinical attachment level) were recorded at baseline and 3 months.Statistical Analysis Used:All the obtained data were sent for statistical analyses using SPSS version 18.Results:The periodontitis and the Achyranthes were statistically analyzed. A comparison of clinical parameters for test group and control group from baseline to 3 months was done using paired t-test. Intergroup comparison for both the groups was done using independent sample t-test.Conclusions:A. aspera gel when delivered locally along with SRP showed a beneficial effect. A. aspera gel as a non-surgical local drug delivery system proved to be without any side effects in the management of periodontitis. A. aspera gel has strong anti-inflammatory effects in addition to its antioxidant activity.

Clinical Effects of Subgingivally Delivered Achyranthes Aspera Gel in Chronic Periodontitis: A Clinical and Microbiological Study

“…In the present study, achyranthes aspera drug is used in gel form and was chosen because of its antioxidant, antimicrobial, and anti-inflammatory properties, its ability to maintain effective concentration at the target site, no systemic toxicity, and its proven clinical efficacy. Studies done by Ramnarayana et al ,[ 14 ] Bansal et al ,[ 15 ] and Yadav et al ,[ 16 ] also support the similar benefits of achyranthes aspera as an adjunct to SRP. For successful periodontal treatment, two important clinical parameters are a decrease in PPD and a gain in CAL.…”

A Comprehensive Study on Ethno-Pharmacological Exploration of Achyranthes aspera Linn.

“…Thirty patients with chronic periodontitis were taken into consideration and 15 of which were treated with scaling and root planing followed by subgingival application of Achyranthes aspera gel, and they exhibited good prognosis without any side effects. Antimicrobial, antioxidant, anti-inflammatory and immunestimulant properties of Achyranthes aspera might be playing role in its beneficial activity as a nonsurgical local drug delivery system in management of periodontitis (Boyapati et al, 2017).…”

Can Achyranthes Aspera Be Used In Dentistry?

“…A study by Ramanarayana Boyapati et al, 2017 had conducted an experiment evaluating the usage of Achyranthes aspera in the management of chronic periodontitis 32 . The study has concluded that A. aspera gel when delivered locally along with scaling and root planing had shown a beneficial effect.…”

“…The study has concluded that A. aspera gel when delivered locally along with scaling and root planing had shown a beneficial effect. A. aspera gel as a non-surgical local drug delivery system proved to be without any side effects in the management of periodontitis 32 . A. aspera gel has got strong anti-inflammatory effects in addition to its antioxidant activity which has been discussed in the next paragraph 32 .…”