Efficacy of Listerine<sup>®</sup> Antiseptic in reducing viral contamination of saliva

Meiller, Timothy F.; Silva, Arley; Ferreira, Sônia Maria Soares; Jabra‐Rizk, Mary Ann; Kelley, Jacqueline I.; DePaola, Louis G.

doi:10.1111/j.1600-051x.2005.00673.x

Cited by 57 publications

(45 citation statements)

References 7 publications

(9 reference statements)

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“…Preoperative mouthwash containing oxidative agents, such as 1–1.5% hydrogen peroxide or 0.2% povidione iodine, were reported to be viricide [ 77 , 78 ]. Antiseptic mouth rinses, e.g., Chlorhexidine (0.2%) and Listerine ® (with adjunctive alcohol) may also exhibit viricide properties [ 79 , 80 ]. In contrast, Chorhexidine (0.1% and 0.2%) without adjunctive alcohol are suspected not to be effective against viruses [ 78 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

Recommendations for Dental Care during COVID-19 Pandemic

Gurzawska‐Comis

Becker

Brunello

et al. 2020

JCM

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Dental clinics were suspected to be a hotspot for nosocomial transmission of coronavirus disease 19 (COVID-19), yet there has been no clear recommendation about emergency dental care and appropriate personal protective equipment during pandemics. In this paper, we aim to summarize recommendations for (i) patient risk assessment, (ii) patient triage, and (iii) measures to prevent infection of health professionals and nosocomial transmission in dental clinics. The available evidence was collected by performing searches on PubMed, Embase, and Cochrane databases. We reviewed papers on COVID-19, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza, and related respiratory viral diseases. Legal and ethical frameworks, as well as international (e.g., World Health Organization (WHO)) and national (e.g., public health institutes, dental associations) guidelines were screened to summarize recommendations related to dental emergency care. To assess the patient risk, a questionnaire was developed to classify patients at unknown, high, and very high risk. Patient triage recommendations were summarized in a flow chart that graded the emergency level of treatments (i.e., urgent, as soon as possible, and postpone). Measures to prevent disease transmission based on current evidence were grouped for dental health professionals, dental clinics, and patients. The present recommendations may support health professionals implement preventative measures during the pandemic.

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Section: Resultsmentioning

confidence: 99%

Recommendations for Dental Care during COVID-19 Pandemic

Gurzawska‐Comis

Becker

Brunello

et al. 2020

JCM

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“…Very limited evidence is available for other products that are frequently recommended in cross-contamination preventive protocols in viral infections: & Hydrogen peroxide [16] is frequently recommended as part of measures of control of COVID-19, despite the limited available evidence, very limited substantivity [49], or limited impact on dental biofilms [50]. & Essential oil mouth rinses, since there are suggestions of their possible benefits in controlling viral contamination, at least for herpes viruses [51]. However, its use has seldomly been suggested in the COVID-19 context.…”

Section: Other Productsmentioning

confidence: 99%

Is the oral cavity relevant in SARS-CoV-2 pandemic?

et al. 2020

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Objectives Recent scientific evidences suggest a relevant role of the oral cavity in the transmission and pathogenicity of SARS-CoV-2. Methods A literature search was performed in PubMed, up to April 30, 2020, focusing on SARS-CoV-2, COVID-19, oral cavity, and antimicrobial agents. Results Oral viral load of SARS-CoV-2 has been associated with the severity of COVID-19, and thus, a reduction in the oral viral load could be associated with a decrease in the severity of the condition. Similarly, a decrease in the oral viral load would diminish the amount of virus expelled and reduce the risk of transmission, since (i) during the first 10 days, the virus mainly accumulates at the nasal, oral, and pharyngeal area; (ii) the number of angiotensin-converting enzyme (ACE2) receptor is greater in the salivary glands as compared with the lungs; and (iii) salivary droplets represent the most relevant transmission route. To reduce the oral viral load, antiseptic agents may be used, although the evidence on its efficacy is indirect and weak. Conclusions Antiseptic mouth rinses, such as those containing cetylpyridinium chloride or povidone-iodine, may be able to decrease the severity of COVID-19 by reducing oral viral load in infected subjects and decreasing the risk of transmission by limiting viral load in droplets, generated in normal life, or in aerosols, produced during dental procedures. Well-designed clinical and preclinical research must be conducted to support these hypotheses. Clinical relevance Antiseptic mouth rinses may help in decreasing the severity of COVID-19 and in reducing the risk of transmission.

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“…Its antibacterial effect is based on blockade of cellular metabolism 6 . In addition it has an anti-mycotic and anti-viral effect (Miller et al) 7 . Listerine is very good at preventing plaque and removing existing plaque as well.…”

Section: Discussionmentioning

confidence: 99%