Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis

Martínez‐Escribano, Jorge; González, Rafael; Quecedo, Esther; Febrer, I.

doi:10.1046/j.1365-4362.1999.00743.x

Cited by 34 publications

(20 citation statements)

References 12 publications

(13 reference statements)

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“…Complete removal is almost impossible and recurrences inevitable, among others due to the underlying primary metabolic defect, lack of encapsulation, the large size and anatomic distribution of the lesions [21,51]. Furthermore, lipoma-derived stem cells have been suggested to play an important role in lipoma recurrence after lipoma liposuction [52].…”

Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stromal Cells from Lipomas: Isolation, Characterisation and Review of the Literature

Tremp

Menzi²,

Tchang³

et al. 2016

Pathobiology

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Objective: The aim of this study was to characterize adipose-derived stromal cells (ADSCs) from patients diagnosed with multiple symmetric lipomatosis (MSL) in order to obtain potentially new insights into the pathophysiology, pathogenesis and treatment of this disease. Methods: Cells from the stromal vascular fraction were analysed by the colony-forming efficiency assay and flow cytometry using standard markers. Moreover, the power of adipogenic plasticity was evaluated. Finally, a literature review was performed from 1982 to 2015 using the US National Institutes of Health's PubMed database. Results: Three European-descent patients diagnosed with either MSL type I or II could be identified for analysis. The resulting mean colony-forming efficiency assay was 14.3 ± 5%. Flow-cytometric analysis of the ADSCs revealed high levels of CD34 (70 ± 9%), CD45 (37 ± 13%) and CD73 (55.8 ± 14%), whereas low levels of CD31 (16.8 ± 14%) and CD105 (5.8 ± 0.7%) were detected. Furthermore, ADSCs showed a strong adipogenic potential, which is in line with the literature review. The stem cell pool in lipoma shows several alterations in biological activities, such as proliferation, apoptosis and stemness. Conclusions: ADSCs from lipoma may be interesting in the application of regenerative medicine. We discuss possible molecular treatment options to regulate their activities at the source of the MSL.

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Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stromal Cells from Lipomas: Isolation, Characterisation and Review of the Literature

Tremp

Menzi²,

Tchang³

et al. 2016

Pathobiology

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“…3) Surgery: Surgical resection and liposuction provide the only means of dramatically decreasing the MSL SAT [94][95][96][97] . In a majority of cases of MSL Type II and III, resection or liposuction of the lipomatosis is considered cosmetic and insurance companies are reluctant to cover this procedure [98] .…”

Section: Msl Treatment Recommendationsmentioning

confidence: 99%

Rare adipose disorders (RADs) masquerading as obesity

2012

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Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue (SAT) of RADs. RAD SAT likely results from the growth of a brown stem cell population with secondary lymphatic dysfunction in MSL, or by primary vascular and lymphatic dysfunction in lipedema and DD. People with RADs do not lose SAT from caloric limitation and increased energy expenditure alone. In order to improve recognition of RADs apart from obesity, the diagnostic criteria, histology and pathophysiology of RADs are presented and contrasted to familial partial lipodystrophies, acquired partial lipodystrophies and obesity with which they may be confused. Treatment recommendations focus on evidencebased data and include lymphatic decongestive therapy, medications and supplements that support loss of RAD SAT. Associated RAD conditions including depression, anxiety and pain will improve as healthcare providers learn to identify and adopt alternative treatment regimens for the abnormal SAT component of RADs. Effective dietary and exercise regimens are needed in RAD populations to improve quality of life and construct advanced treatment regimens for future generations.

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“…Eiposuction as well as open surgical excision can be performed in patients with severe cosmetic problems (8). Complete excision of the lesions is difficult because of the nonencapsulated fat tissue and compromised neurovascular structures.…”

Section: Discussionmentioning

confidence: 99%