Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study

Abstract

A high dose of linezolid should be considered as a possible therapeutic agent for the treatment of post-sternotomy infection caused by MRSA.

Adjunctive hyperbaric oxygen therapy or alone antibiotherapy? Methicillin Resistant staphylococcus aureus mediastinitis in a rat model

“…In this study, we used previously applied experimental rat mediastinitis models [ 18 , 19 ] . When the literature was examined, we found several animal models using tigecycline, vancomycin and HBO against MRSA, so we aimed to use these antibiotics and HBO.…”

Hyperbaric Oxygen as Adjunctive Therapy in Experimental Mediastinitis

“…We used vancomycin, teicoplanin, and linezolid as they were utilized in the treatment of serious infections due to methicillin resistant staphylococci in experimental animal models [11][12][13].…”

Comparison of the Therapeutic Efficacy of Linezolid and Vancomycin and Correlation of Serum and Tissue Malondialdehyde and Myeloperoxidase in an Experimental Mediastinitis Model

“…Efficacy of linezolid in 50 or 100 mg/kg/d in a rat model of pneumococcal pneumonia was also evaluated, and the latter was found to be more effective [34]. We have previously shown that the standard dose mimicking therapeutic dose given to humans was not effective in reducing bacterial count in mediastinum and sternum, but the double dose was [35]. As linezolid is not investigated enough in cardiovascular infections, and as there are reports of treatment failure of another serious cardiovascular infection, endocarditis, with a standard dose used in humans [36], and as our MRSA strain was less susceptible in vitro, we decided to investigate the efficacy of a double dose in mediastinitis, which was previously reported to be effective in the treatment of serious infections and to compare it with vancomycin.…”