Efficacy of Leukocyte- and Platelet-Rich Fibrin in Wound Healing

Chignon-Sicard, Bérengère; Georgiou, Charalambos; Fontas, Éric; David, S.; Dumas, P; Ihraï, T.; Lebreton, E.

doi:10.1097/prs.0b013e31826d1711

Cited by 51 publications

(26 citation statements)

References 35 publications

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“…The use of L‐PRF in oral surgery and wound repair seems to be associated with less postoperative pain and discomfort (Chignon‐Sicard et al. , Jankovic et al. , Kumar et al.…”

mentioning

confidence: 99%

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Temmerman

Vandessel

Castro

et al. 2016

J Clinic Periodontology

155

214

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“…The use of L‐PRF in oral surgery and wound repair seems to be associated with less postoperative pain and discomfort (Chignon‐Sicard et al. , Jankovic et al. , Kumar et al.…”

mentioning

confidence: 99%

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Temmerman

Vandessel

Castro

et al. 2016

J Clinic Periodontology

155

214

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show abstract

“…WBC, mainly neutrophils, monocytes and lymphocytes, may accumulate at wound site, kill bacteria, remove cells under apoptosis or necrosis, and also produce various cytokines that benefit wound healing. Therefore, the decrease in WBC may weaken the inflammatory response required for normal wound healing, leading to delayed wound healing . PLT, known as a “coagulant,” is required for haemostasis in the initial stage of wound healing, and the platelet‐derived growth factor (PDGF) secreted by PLT plays an important role in enhancing cell proliferation .…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the decrease in WBC may weaken the inflammatory response required for normal wound healing, leading to delayed wound healing. [35,36] PLT, known as a "coagulant," is required for haemostasis in the initial stage of wound healing, and the platelet-derived growth factor (PDGF) secreted by PLT plays an important role in enhancing cell proliferation. [37] Given this, reduced PLT number may inhibit wound healing.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin accelerates wound healing in combined radiation and wound injury in mice

Liu

Hao

Huang

et al. 2017

Experimental Dermatology

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Impaired wound healing caused by radiation happens frequently in clinical practice, and the exact mechanisms remain partly unclear. Various countermeasures have been taken to tackle with this issue. Ghrelin was considered as a potent endogenous growth hormone-releasing peptide, and its role in enhancing wound repair and regeneration was firstly investigated in whole-body irradiated (γ-ray) mice in this study. Collagen deposition and neovascularization were mostly discussed. The results demonstrated that ghrelin administration promoted cutaneous wound healing in irradiated mice, followed with reduced average wound closure time, increased spleen index (SI) and improved haematopoiesis. After isolation and analysis of granulation tissues in combined radiation and wound injury (CRWI) mice treated with and without ghrelin, a phenomenon of increased DNA, hexosamine, nitrate and nitrite synthesis, elevated collagen content and enhanced neovascularization was observed after ghrelin treatment. Western blotting indicated that ghrelin also increased the expression of vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β), both responsible for wound healing. However, previous administration of growth hormone secretagogue receptor 1a (GHS-R1a) blocker blunted these therapeutic effects of ghrelin on CRWI mice. Our results identify ghrelin as a novel peptide that could be used for radiation-induced impaired wound healing.

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“…A single L-PRF application on fresh postoperative hand wounds was associated with faster reepithelialization, with a median improvement of 5 days to the standard treatment of 29 days [57].…”

Section: Human Trialsmentioning

confidence: 98%

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

Sclafani

Azzi

2015

Aesth Plast Surg

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In facial plastic surgery, the potential for direct delivery of growth factors from platelet preparations has been of particular interest for use in facial rejuvenation, recovery after facial surgery, and wound healing. A literature search was conducted through PubMed for the terms PRP, PRFM, platelet-rich plasma, platelet-rich fibrin matrix, platelet preparations, platelet therapy, growth factors, platelet facial, platelet facial rejuvenation, platelet wound healing, platelet plastic surgery. Articles pertaining to the use of platelet preparations in facial surgery and wound healing in plastic surgery after 2001 were included. Thirteen in vitro studies showed use of platelet-rich plasma (PRP) and platelet-rich fibrin matrix (PRFM) had a significant effect on cellular activity. Twenty-four out of 28 animal studies exhibited favorable results with use of a platelet preparation, including five of six studies that showed enhanced fat graft survival with addition of a platelet preparation. Twenty-three case series and clinical trials were identified, only two of which showed no differences. Twenty-one reported favorable results with use of various platelet preparations. A total of 47 studies used PRP, four studies evaluated Leukocyte-rich PRP, and fourteen studies used PRFM. The vast majority of studies examined show a significant and measurable effect on cellular changes, wound healing, and facial esthetic outcomes with use of platelet preparations, both topical and injectable. One must also consider possible publication bias against null results that may have had an influence on the data that were available for review. However, the preponderance of studies suggests that platelet preparations might represent an as-of-yet untapped adjunct in facial plastic surgery.

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Efficacy of Leukocyte- and Platelet-Rich Fibrin in Wound Healing

Abstract: Therapeutic, II.

Cited by 51 publications

References 35 publications

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

The use of leucocyte and platelet‐rich fibrin in socket management and ridge preservation: a split‐mouth, randomized, controlled clinical trial

Ghrelin accelerates wound healing in combined radiation and wound injury in mice

Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature

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