Efficacy of Lenvatinib Combined with Transcatheter Intra-Arterial Therapies for Patients with Advanced-Stage of Hepatocellular Carcinoma: A Propensity Score Matching

Shimose, Shigeo; Iwamoto, Hideki; Niizeki, Takashi; Tanaka, Masatoshi; Shirono, Tomotake; Moriyama, Etsuko; Noda, Yu; Nakano, Masahito; Suga, Hideya; Kuromatsu, Ryoko; Torimura, Takuji; Koga, Hironori; Kawaguchi, Takumi

doi:10.3390/ijms241813715

Cited by 4 publications

(2 citation statements)

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“…29 Propensity scores for all the patients were estimated by a logistic regression model using the baseline characteristics of age and smoking as covariates as previously described. [31][32][33] Data were analyzed using JMP Pro15 (SAS Institute Inc.).…”

Section: Discussionmentioning

confidence: 99%

Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Nakane,

Fukunaga,

Nakano

et al. 2024

Hepatology Research

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AimThe incidence of Helicobacter pylori‐negative gastric cancer (HPNGC) is increasing worldwide. Recently, metabolic dysfunction‐associated fatty liver disease (MAFLD) has been reported to be associated with various cancers, but its association with HPNGC has not been reported. We aimed to identify important independent factors associated with HPNGC, including MAFLD.MethodsThis multicenter observational cohort study enrolled patients with gastric cancer (n=1,078) and health checkup examinees (n=17,408). We analyzed patients with HPNGC (n=26) and healthy participants with no Helicobacter pylori infection or any abnormal findings on upper gastrointestinal endoscopy (n=1,130). A logistic regression model was used to identify independent factors associated with HPNGC. The priority of the factors associated with HPNGC was evaluated using a decision tree algorithm and random forest analysis.ResultsAmong all patients with gastric cancer, 2.4% (26/1,078) were diagnosed with HPNGC (mean age, 64 years; male/female, 13/13). In the logistic regression analysis, age, smoking, and MAFLD (odds ratio, 6.5359; 95% confidence interval, 2.5451–16.7841; p<0.0001) were identified as independent factors associated with HPNGC. MAFLD was also identified as the most important classifier for the presence of HPNGC in decision tree analyses. HPNGC was observed in 5.2% of patients with MAFLD and 0.8% of patients without MAFLD. In the random forest analysis of the HPNGC, MAFLD was identified as the distinguishing factor with the highest variable importance (0.32).ConclusionsMAFLD was the most influential independent factor associated with HPNGC. These findings suggest that fatty liver and metabolic dysfunction may be involved in the pathogenesis of HPNGC.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Impact of metabolic dysfunction‐associated fatty liver disease on the incidence of Helicobacter pylori‐negative gastric cancer

Nakane,

Fukunaga,

Nakano

et al. 2024

Hepatology Research

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“…For this reason, many studies suggest the introduction of a novel approach based on "converse therapeutic hierarchy" [6], in which the advanced treatment modalities may be better integrated to achieve patient-tailored management. In this context, we included a retrospective study enrolling 115 HCC patients at advanced stage who received lenvatinib (LEN) combined with transcatheter intra-arterial therapy (TIT) after propensity score matching observed that this combination therapy may improve prognosis with respect to lenvatinib monotherapy in advanced HCC patients, particularly those <75 years of age and with modified albumin bilirubin (m-ALBI) grade 1 [7].…”

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confidence: 99%